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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CD40 958 CD40 molecule, TNF receptor superfamily member 5  20p50, Bp50 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22687258   2013Cell line : -

Source : -

Sample Type : -

No. of Sample : 31

Stage : -

-Down-regulation-The dense infiltration of CD40+ TAM in colorectal cancer tissues indicates a favorable prognosis, which suggests that CD40 plays an important role in the tumor immunity of colorectal cancer.


Gene Details



NC_000020.10 (44746899..44758384)

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Gene Type protein coding
Gene Family Tumor necrosis factor receptor superfamily, "CD molecules"
Description This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]  
Chromosome 20
Location 20q12-q13.
Start 44746899  
End 44758384  
Strand +  
Gene Sequence

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Length 11486  
OMIM ID 109535   
HGNC ID HGNC:11919   
Unigene ID Hs.472860   
Ensembl ID ENSG00000101017   
PharmGKB ID PA36612   

mRNA Information


mRNA ID XM_005260619.2
Exon join(1..145,3571..3649,3984..4109,4361..4507,9889..9987, 10081..10109,10633..11364)  
mRNA Sequence

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Length 1357  



CDS Information


   
Location95..784
CDS Sequence

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CCDS ID CCDS13393.1



Protein Information


      
Protein IDXP_005260676.1
Protein NameCD40 molecule, TNF receptor superfamily member 5
Molecular Wt. (Da)25359
Protein Sequence

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Length 229  
Uniprot IDQ16649
Ensembl Protein ID ENSP00000297689  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
329BIRC23419NP_001157.1in vitro11562359   
330BIRC33426NP_001156.1in vitro11562359   
857CAV13028NP_001744.2in vivo14665433   
867CBL1320NP_005179.2in vitro12637493   
1326MAP3K81863NP_005195.2in vivo15670770   
3308HSPA49025NP_002145.3in vivo12356871   
3312HSPA87205NP_006588.1in vivo12356871   
3566IL4R990NP_000409.1in vitro;in vivo12207328   
3718JAK32547NP_000206.2in vitro913   341   710   395   671   
5295PIK3R11381NP_852664.1in vitro12637493   


Pathway Information


                                                                                                
Pathway Name Pathway ID
Allograft rejection hsa05330
Asthma hsa05310
Autoimmune thyroid disease hsa05320
Cell adhesion molecules (CAMs) hsa04514
Cytokine-cytokine receptor interaction hsa04060
Epstein-Barr virus infection hsa05169
HTLV-I infection hsa05166
Intestinal immune network for IgA production hsa04672
Malaria hsa05144
NF-kappa B signaling pathway hsa04064
Primary immunodeficiency hsa05340
Systemic lupus erythematosus hsa05322
Toll-like receptor signaling pathway hsa04620
Toxoplasmosis hsa05145
Transcriptional misregulation in cancer hsa05202
Viral myocarditis hsa05416


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd1340726-186  TNFRSF5
cl2285526-186  TNFRSF superfamily
cd1341128-186  TNFRSF11A
cd1342228-187  TNFRSF5_teleost
cd1057737-186  TNFRSF1B
cd1340526-133  TNFRSF14_teleost
cd1057538-186  TNFRSF6B
cd1583537-143  TNFRSF1B_teleost
cd1058338-186  TNFRSF21
cd1058138-153  TNFRSF11B
cd1583626-146  TNFRSF11A_teleost
cd1341625-186  TNFRSF16
cd0018537-122  TNFRSF
cd1340626-190  TNFRSF4
cd1341238-149  TNFRSF11B_teleost
cd1057924-143  TNFRSF6
cd1058226-124  TNFRSF14
cd1342325-127  TNFRSF6_teleost
cd1341792-212  TNFRSF18
cd1583426-168  TNFRSF1A_teleost
cd1057837-128  TNFRSF3
cd1583926-147  TNFRSF_viral
cd1341090-188  TNFRSF9
cd1342437-167  TNFRSF9_teleost
cd00185123-187  TNFRSF
cd134088-119  TNFRSF7
cd1057626-151  TNFRSF1A
cd13419141-187  TNFRSF19L
cd1583726-143  TNFRSF26
smart00208105-143  TNFR
cd13405125-190  TNFRSF14_teleost
cd10577125-187  TNFRSF1B
cd15835123-187  TNFRSF1B_teleost
cd10582125-187  TNFRSF14
cd1342037-119  TNFRSF25
PHA02637Apr-77  PHA02637
cl22868Apr-77  PHA02637 superfamily
cd1341938-110  TNFRSF19L
pfam0002026-59  TNFR_c6


Ontology Information


   
HPRD ID1239
Molecular ClassCell surface receptor
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO