Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CD40LG | 959 | CD40 ligand | X | CD40L, TRAP, gp39, hCD40L, CD154 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24706377 | 2014 | Cell line : - Source : - Sample Type : Blood samples No. of Sample : 59 CRC and 29 control Stage : - | Sandwich enzyme-linked immunoassay | Up-regulation | - | sCD40L correlated with sP-selectin in patients with advanced stage of CRC, which might indicate its possible participation in metastasis formation. The receiver-operator curve for CRC patients indicated that the area under the curve for sCD40L was 0.915, which may indicate its high efficiency as an inflammatory marker. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Tumor necrosis factor (ligand) superfamily, "CD molecules", "Endogenous ligands" |
| Description | The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. |
| Chromosome | X |
| Location | Xq26 |
| Start | 136648177 |
| End | 136660390 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 12214 |
| OMIM ID | 300386 |
| HGNC ID | HGNC:11935 |
| Unigene ID | Hs.592244 |
| Ensembl ID | ENSG00000102245 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_000074.2 |
|---|---|
| Exon | join(1..228,2090..2221,6197..6254,8180..8242,10863..12214) | mRNA Sequence | Download Select all |
| Length | 1834 |
CDS Information
| Location | join(73..228,2090..2221,6197..6254,8180..8242, 10863..11239) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS14659.1 |
Protein Information
| Protein ID | NP_000065.1 |
|---|---|
| Protein Name | CD40 ligand |
| Molecular Wt. (Da) | 29142 |
| Protein Sequence | Download Select all |
| Length | 261 |
| Uniprot ID | O95467 |
| Ensembl Protein ID | ENSP00000323571 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 240 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 958 | CD40 | 178 | NP_001241.1 | in vitro;in vivo | 1 064 799 275 164 050 000 000 |
| 3514 | IGKC | 921 | AAH73779.1 | in vitro | 11525169 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Allograft rejection | hsa05330 |
| Asthma | hsa05310 |
| Autoimmune thyroid disease | hsa05320 |
| Cell adhesion molecules (CAMs) | hsa04514 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Intestinal immune network for IgA production | hsa04672 |
| Malaria | hsa05144 |
| NF-kappa B signaling pathway | hsa04064 |
| Primary immunodeficiency | hsa05340 |
| Systemic lupus erythematosus | hsa05322 |
| T cell receptor signaling pathway | hsa04660 |
| Toxoplasmosis | hsa05145 |
| Viral myocarditis | hsa05416 |
Structure Information
| PDB ID | 1ALY |
|---|---|
| Resolution | 2 |
| Method | X-RAY DIFFRACTION |
| Chains | A |
| Molecule | CD40 LIGAND |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00184 | 122-259 | TNF |
| cl00147 | 122-259 | TNF superfamily |
| smart00207 | 138-261 | TNF |
| pfam00229 | 138-261 | TNF |
Ontology Information
| HPRD ID | 11750 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Peroxidase activity (GO:0004601) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.