Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CD44 | 960 | CD44 molecule (Indian blood group) | 11 | IN, MC56, Pgp1, CD44R, HCELL, CSPG8 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23251004 | 2013 | Cell line : - Source : Beijing Cancer Hospital and Institute (Beijing, China) Sample Type : - No. of Sample : - Stage : - | real-time PCR, Immunohistochemistry, tissue microarrays, immunofluorescence and Western blotting | Unknown | - | OPN-CD44 interaction is important for colorectal cancer progression and could serve as a potential therapeutic target for the treatment of colorectal cancer. |
| 21764578 | 2012 | Cell line : - Source : First Hospital of Jilin Medical University Sample Type : - No. of Sample : 120 Stage : - | real-time RT-PCR,Immunofluorescent | Up-regulation | - | CD133 and CD44 proteins were highly co-expressed in colorectal cancer with early liver metastases, and may be a potential biomarker for the early liver metastases. CD133 and CD44 were significantly higher co-expressed in colorectal cancer with early liver metastases compared to those without early liver metastases, and the content of CD133 and CD44 proteins decreased following growth of the transplanted tumors. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Blood group antigens", "Proteoglycans / Cell surface : Other" |
| Description | The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. |
| Chromosome | 11 |
| Location | 11p13 |
| Start | 35138870 |
| End | 35232402 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 93533 |
| OMIM ID | 107269 |
| HGNC ID | HGNC:1681 |
| Unigene ID | Hs.502328 |
| Ensembl ID | ENSG00000026508 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_000610.3 |
|---|---|
| Exon | join(1..501,37706..37871,41405..41538,47963..48031, 50966..51196,57877..58005,59252..59377,62213..62326, 62802..62918,65643..65771,67243..67374,69236..69337, 71096..71185,72377..72580,75983..76045,80447..80518, 82785..82863,90260..93533) | mRNA Sequence | Download Select all |
| Length | 5748 |
CDS Information
| Location | join(435..501,37706..37871,41405..41538,47963..48031, 50966..51196,57877..58005,59252..59377,62213..62326, 62799..62918,65643..65771,67243..67374,69236..69337, 71096..71185,72377..72580,75983..76045,80447..80518, 82785..82863,90260..90464) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_000601.3 |
|---|---|
| Protein Name | CD44 molecule (Indian blood group) |
| Molecular Wt. (Da) | 79211 |
| Protein Sequence | Download Select all |
| Length | 742 |
| Uniprot ID | P21695 |
| Ensembl Protein ID | ENSP00000301149 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 672 |
| S | Phosphorylation | 706 |
| S | Dephosphorylation | 706 |
| S | Phosphorylation | 629 |
| S | Phosphorylation | 663 |
| S | Dephosphorylation | 663 |
| S | Phosphorylation | 423 |
| S | Phosphorylation | 457 |
| S | Dephosphorylation | 457 |
| S | Phosphorylation | 291 |
| S | Phosphorylation | 325 |
| S | Dephosphorylation | 325 |
| R | Proteolytic Cleavage | 162 |
| R | Proteolytic Cleavage | 186 |
| G | Proteolytic Cleavage | 192 |
| R | Proteolytic Cleavage | 162 |
| R | Proteolytic Cleavage | 186 |
| G | Proteolytic Cleavage | 192 |
| R | Proteolytic Cleavage | 162 |
| R | Proteolytic Cleavage | 186 |
| G | Proteolytic Cleavage | 192 |
| R | Proteolytic Cleavage | 162 |
| R | Proteolytic Cleavage | 186 |
| G | Proteolytic Cleavage | 192 |
| S | Phosphorylation | 706;- |
| S | Phosphorylation | 663;- |
| S | Phosphorylation | 457;- |
| S | Phosphorylation | 325;- |
| S | Phosphorylation | 45 |
| S | Phosphorylation | 58 |
| T | Phosphorylation | 62 |
| S | Phosphorylation | 45 |
| S | Phosphorylation | 58 |
| T | Phosphorylation | 62 |
| S | Phosphorylation | 45 |
| S | Phosphorylation | 58 |
| T | Phosphorylation | 62 |
| S | Phosphorylation | 45 |
| S | Phosphorylation | 58 |
| T | Phosphorylation | 62 |
| S | Phosphorylation | 45 |
| S | Phosphorylation | 58 |
| T | Phosphorylation | 62 |
| S | Phosphorylation | 686 |
| S | Phosphorylation | 643 |
| S | Phosphorylation | 437 |
| S | Phosphorylation | 305 |
| S | Phosphorylation | 697 |
| S | Phosphorylation | 654 |
| S | Phosphorylation | 448 |
| S | Phosphorylation | 316 |
| T | Phosphorylation | 720 |
| T | Phosphorylation | 677 |
| T | Phosphorylation | 471 |
| T | Phosphorylation | 339 |
| N | Glycosylation | 57 |
| N | Glycosylation | 57 |
| N | Glycosylation | 57 |
| N | Glycosylation | 57 |
| N | Glycosylation | 57 |
| S | Phosphorylation | 717 |
| S | Phosphorylation | 718 |
| S | Phosphorylation | 674 |
| S | Phosphorylation | 675 |
| S | Phosphorylation | 468 |
| S | Phosphorylation | 469 |
| S | Phosphorylation | 336 |
| S | Phosphorylation | 337 |
| T | Phosphorylation | 587 |
| T | Phosphorylation | 544 |
| T | Phosphorylation | 338 |
| S | Phosphorylation | 704 |
| S | Phosphorylation | 661 |
| S | Phosphorylation | 455 |
| S | Phosphorylation | 323 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2617 | GARS | 2617 | AAH00065.1 | in vivo;yeast 2-hybrid | 15452148 |
| 5585 | PKN1 | 3019 | NP_998725.1 | in vivo | 15123640 |
| 8174 | MADCAM1 | 35 | NP_570117.1 | in vitro | 2474557 |
| 23365 | ARHGEF12 | 9207 | NP_056128.1 | in vivo | 16565089 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| ECM-receptor interaction | hsa04512 |
| Epstein-Barr virus infection | hsa05169 |
| Hematopoietic cell lineage | hsa04640 |
| MicroRNAs in cancer | hsa05206 |
| Proteoglycans in cancer | hsa05205 |
| Shigellosis | hsa05131 |
Structure Information
| PDB ID | 1POZ |
|---|---|
| Resolution | |
| Method | ? SOLUTION NMR |
| Chains | A |
| Molecule | CD44 antigen |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03516 | 26-170 | Link_domain_CD44_like |
| cl02612 | 26-170 | Link_Domain superfamily |
| smart00445 | 30-120 | LINK |
| pfam00193 | 32-119 | Xlink |
| cd01102 | 32-119 | Link_Domain |
| cd03515 | 32-119 | Link_domain_TSG_6_like |
| cd03520 | 33-119 | Link_domain_CSPGs_modules_2_4 |
| cd03518 | 38-119 | Link_domain_HAPLN_module_1 |
| cd03517 | 33-119 | Link_domain_CSPGs_modules_1_3 |
| pfam05109 | 304-623 | Herpes_BLLF1 |
Ontology Information
| HPRD ID | 11819 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Peroxidase activity (GO:0004601) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P16070 | DB08818 | Hyaluronic acid | SmallMoleculeDrug |