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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 11445004 | 2001 | Cell line : HT29, Caco2 Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR | Down-regulation | - | CLCA1 could specify a new tumor suppressor and that, as in breast�cancer,�CLCA2may function as a tumor suppressor in�colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. [provided by RefSeq, Jul 2008] |
| Chromosome | 1 |
| Location | 1p22.3 |
| Start | 86889769 |
| End | 86922241 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 32473 |
| OMIM ID | 604003 |
| HGNC ID | HGNC:2016 |
| Unigene ID | Hs.241551 |
| Ensembl ID | ENSG00000137975 |
| PharmGKB ID | PA26543 |
Protein Information
| Protein ID | NP_006527.1 |
|---|---|
| Protein Name | chloride channel accessory 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 943 |
| Uniprot ID | O60885 |
| Ensembl Protein ID | ENSP00000263377 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Pancreatic secretion | hsa04972 |
| Renin secretion | hsa04924 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00198 | 312-466 | vWFA |
| cl00057 | 312-466 | vWFA superfamily |
| pfam08434 | 7-265 | CLCA_N |
| cl07163 | 7-265 | CLCA_N superfamily |
| pfam09315 | 494-674 | DUF1973 |
| cl09605 | 494-674 | DUF1973 superfamily |
| pfam00092 | 312-480 | VWA |
| smart00327 | 312-472 | VWA |
| pfam13519 | 312-483 | VWA_2 |
| cd01466 | 314-468 | vWA_C3HC4_type |
| cd01465 | 313-447 | vWA_subgroup |
| TIGR00868 | 33-883 | hCaCC |
Ontology Information
| HPRD ID | 19391 |
|---|---|
| Molecular Class | Membrane transport protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.