Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FEZ1 | 9638 | fasciculation and elongation protein zeta 1 (zygin I) | 11 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25667121 | 2015 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 160 Stage : - | - | Down-regulation | - | LZTS1 plays a potential tumor suppressor role in CRC progression and represents a valuable clinical prognostic marker of this disease. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008] |
| Chromosome | 11 |
| Location | 11q24.2 |
| Start | 125315641 |
| End | 125366206 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 50566 |
| OMIM ID | 604825 |
| HGNC ID | HGNC:3659 |
| Unigene ID | Hs.224008 |
| Ensembl ID | ENSG00000149557 |
| PharmGKB ID | PA28100 |
Protein Information
| Protein ID | NP_005094.1 |
|---|---|
| Protein Name | fasciculation and elongation protein zeta 1 (zygin I) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 392 |
| Uniprot ID | O00541 |
| Ensembl Protein ID | ENSP00000334612 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 580 | BARD1 | 3354 | NP_000456.2 | yeast 2-hybrid | 15383276 |
| 3064 | HTT | 883 | NP_002102.4 | in vitro;yeast 2-hybrid | 15383276 |
| 4077 | NBR1 | 1326 | NP_114064.1 | in vivo;yeast 2-hybrid | 11856312 |
| 4750 | NEK1 | 6847 | NP_036356.1 | in vitro;yeast 2-hybrid | 14690447 |
| 4943 | TBC1D25 | 8948 | NP_002527.1 | yeast 2-hybrid | 16484223 |
| 5590 | PRKCZ | 1504 | NP_002735.3 | in vivo;yeast 2-hybrid | 9971736 |
| 5764 | PTN | 1199 | NP_002816.1 | yeast 2-hybrid | 15383276 |
| 6602 | SMARCD1 | 3438 | NP_003067.3 | in vitro;yeast 2-hybrid | 16484223 |
| 9126 | SMC3 | 5829 | NP_005436.1 | in vitro;yeast 2-hybrid | 16484223 |
| 10081 | PDCD7 | 9736 | NP_005698.1 | yeast 2-hybrid | 16484223 |
| 10190 | TXNDC9 | 15592 | NP_005774.2 | yeast 2-hybrid | 16169070 |
| 10519 | CIB1 | 3800 | NP_006375.2 | in vitro;yeast 2-hybrid | 11856312 |
| 10589 | DRAP1 | 3796 | NP_006433.2 | in vitro;yeast 2-hybrid | 16484223 |
| 10989 | IMMT | 2658 | NP_006830.2 | yeast 2-hybrid | 15383276 |
| 11011 | TLK2 | 10527 | AAH44925.1 | yeast 2-hybrid | 16484223 |
| 23122 | CLASP2 | 12054 | NP_055912.1 | in vitro;yeast 2-hybrid | 16484223 |
| 23286 | WWC1 | 10033 | NP_056053.1 | in vitro;yeast 2-hybrid | 16484223 |
| 23774 | BRD1 | 6848 | NP_055392.1 | yeast 2-hybrid | 16484223 |
| 25782 | RAB3GAP2 | 11471 | NP_036546.2 | yeast 2-hybrid | 16484223 |
| 26064 | RAI14 | 9416 | NP_001138997.1 | in vitro;yeast 2-hybrid | 16484223 |
| 27185 | DISC1 | 5553 | NP_061132.2 | yeast 2-hybrid | 12874605 |
| 27336 | HTATSF1 | 2282 | NP_055315.2 | yeast 2-hybrid | 16169070 |
| 51025 | - | 14798 | AAR05948.1 | yeast 2-hybrid | 16169070 |
| 54919 | HEATR2 | 7903 | NP_060272.3 | yeast 2-hybrid | 16169070 |
| 55183 | RIF1 | 10603 | NP_060621.3 | yeast 2-hybrid | 15383276 |
| 56944 | OLFML3 | 14878 | NP_064575.1 | yeast 2-hybrid | 16169070 |
| 57223 | SMEK2 | 13854 | NP_001116436.1 | yeast 2-hybrid | 16169070 |
| 60592 | SCOC | 18027 | NP_115936.2 | yeast 2-hybrid | 16484223 |
| 79866 | C13orf34 | 13389 | NP_079084.2 | yeast 2-hybrid | 16169070 |
| 80178 | C16orf59 | 7840 | NP_079384.2 | yeast 2-hybrid | 16484223 |
| 129563 | DIS3L2 | 14619 | NP_689596.4 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam07763 | 58-300 | FEZ |
| cl06682 | 58-300 | FEZ superfamily |
| pfam10148 | 224-290 | SCHIP-1 |
| cl10845 | 224-290 | SCHIP-1 superfamily |
Ontology Information
| HPRD ID | 6949 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.