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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24727892 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Immunoprecipitation and western blotting,cDNA GeneChip assay,flow cytometry | Up-regulation | - | CD58, a novel surface marker, promotes self-renewal of tumor-initiating cells in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules |
| Description | This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009] |
| Chromosome | 1 |
| Location | 1p13 |
| Start | 117057156 |
| End | 117113715 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 56560 |
| OMIM ID | 153420 |
| HGNC ID | HGNC:1688 |
| Unigene ID | Hs.34341 |
| Ensembl ID | ENSG00000116815 |
| PharmGKB ID | PA26227 |
mRNA Information
| mRNA ID | NM_001779.2 |
|---|---|
| Exon | join(1..191,26490..26783,34866..35129,49111..49188, 51827..51863,56272..56560) | mRNA Sequence | Download Select all |
| Length | 1153 |
Protein Information
| Protein ID | NP_001770.1 |
|---|---|
| Protein Name | CD58 molecule |
| Molecular Wt. (Da) | 28016 |
| Protein Sequence | Download Select all |
| Length | 250 |
| Uniprot ID | P19838 |
| Ensembl Protein ID | ENSP00000226574 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3301 | DNAJA1 | 4159 | NP_001530.1 | yeast 2-hybrid | 16169070 |
| 9709 | HERPUD1 | 7456 | NP_055500.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell adhesion molecules (CAMs) | hsa04514 |
| Epstein-Barr virus infection | hsa05169 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05741 | 39-120 | Ig_CEACAM_D1_like |
| cl11960 | 39-120 | Ig superfamily |
| cd05775 | 35-121 | Ig_SLAM-CD84_like_N |
Ontology Information
| HPRD ID | 1235 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.