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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
RHOBTB1 9886 Rho-related BTB domain containing 1  10KIAA0740 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23258531   2013Cell line : HT29

Source : -

Sample Type : -

No. of Sample : -

Stage : -

ImunohistochemistryDown-regulation-miR-31 acts as an oncogene in colon cancer and identified RhoBTB1 as a new target of miR-31 further study demonstrated that miR-31 contributed to the development of colon cancer at least partly by targeting RhoBTB1.


Gene Details



NC_000010.10 (62629196..62761198, complement)

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Gene Type protein coding
Gene Family BTB/POZ domain containing
Description The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]  
Chromosome 10
Location 10q22.1
Start 62629196  
End 62761198  
Strand -  
Gene Sequence

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Length 132003  
OMIM ID 607351   
HGNC ID HGNC:18738   
Unigene ID Hs.737374   
Ensembl ID ENSG00000072422   
PharmGKB ID PA38664   

mRNA Information


mRNA ID ?NM_001242359.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS7261.1



Protein Information


      
Protein IDNP_001229288.1
Protein NameRho-related BTB domain containing 1
Molecular Wt. (Da)0
Protein Sequence

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Length 696  
Uniprot IDQ9UIK4
Ensembl Protein ID ENSP00000261891  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation480
TPhosphorylation483
SPhosphorylation480
TPhosphorylation483
SPhosphorylation480
TPhosphorylation483

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


      
Pathway Name Pathway ID
Ubiquitin mediated proteolysis hsa04120


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0187313-207  RhoBTB
cl2145513-207  P-loop_NTPase superfamily
cd0015715-206  Rho
smart0017417-208  RHO
cd0413215-223  Rho4_like
cd0187512-208  RhoG
cd0187115-206  Rac1_like
cd0413015-207  Wrch_1
cd0187414-208  Cdc42
cd0187016-208  RhoA_like
cd0413115-208  Rnd
cd0412916-211  Rho2
cd0413515-208  Tc10
cd0413315-208  Rop_like
cd0417213-208  Rnd3_RhoE_Rho8
cd041749-230  Rnd1_Rho6
cd0015415-205  Rab
cd0417316-226  Rnd2_Rho7
cd0413416-211  Rho3
smart0017515-208  RAB
pfam00651476-581  BTB
cl02518476-581  BTB superfamily
smart00225486-583  BTB
cd0088218-201  Ras_like_GTPase
cd0411118-189  Rab39
pfam0847716-143  Miro
cd0186116-208  Rab6
cd0087616-205  Ras
cd0189315-145  Miro1
cd0410615-200  Rab23_like
cd0411716-200  Rab15
cd0413816-205  H_N_K_Ras_like
smart0001016-200  small_GTPase
smart0017316-205  RAS
cd0186516-201  Rab3
cd0412415-208  RabL2
cd0186315-205  Rab18
cd0414513-206  M_R_Ras_like
cd0186916-200  Rab1_Ypt1
cd0186216-208  Rab7
cd0186014-200  Rab5_related
cd0412315-201  Rab21
cd0186715-200  Rab8_Rab10_Rab13_like
cd0412715-189  Rab27A
cd0412115-213  Rab40
cd0411216-189  Rab26
cd0413916-205  RalA_RalB
smart00225396-455  BTB
cl02518396-455  BTB superfamily
cd0414664-209  RERG_RasL11_like
cd0417616-205  Rap2
cd0414116-205  Rit_Rin_Ric
cd0417716-205  RSR1
cd0411815-189  Rab24
cd0186616-206  Rab2
cd0410915-144  Rab28
cd0411615-205  Rab9
cd0410116-206  RabL4
cd0414716-152  Ras_dva
cd0414416-211  Ras2
cd0991415-143  RocCOR
cd0411016-214  Rab35
cd0411915-202  RJL
cd0417516-205  Rap1
cd0411373-205  Rab4
pfam0007116-208  Ras
COG110011-208  Gem1
TIGR0023114-202  small_GTP
PTZ0036916-205  PTZ00369
PLN0310816-202  PLN03108


Ontology Information


   
HPRD ID10280
Molecular ClassGTPase
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO