CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
CDC25C	995	Cell division cycle 25 homolog C (S. pombe)	5	CDC25; PPP1R60

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
17848589	2007	Cell line : - Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncol?gicas (CNIO). Sample Type : - No. of Sample : 15 Stage : Duke Stage A-D	Differential Protein Expression Analysis in Colorectal Cancer with Antibody Microarrays.	Down-regulation	0.514	-
23064444	2012	Cell line : HCT116 Source : - Sample Type : - No. of Sample : - Stage : -	Flow cytometry	Unknown	-	Treatment of HCT116 cells with MHY-449 resulted in growth inhibition and induction of apoptosis in a concentration-dependent manner, and inhibition of proliferation in a time-dependent manner. The induction of apoptosis was observed by decreased cell viability, DNA fragmentation, activation of protein levels involved in death receptors. MHY-449 induced G2/M phase arrest in the cell cycle progression and decrease cyclin B1 expression and its activating partners Cdc25c and Cdc2.

Gene Details

Chromosome: 5; NC_000005.9 (137620959..137667516, complement)
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Gene Type	protein coding
Gene Family	Protein tyrosine phosphatases / Class III Cys-based PTPs, Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
Description	This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq, Jul 2008]
Chromosome	5
Location	5q31
Start	138285265
End	138338355
Strand	-
Gene Sequence	>gi\|568815593:c138338355-138285265 Homo sapiens chromosome 5, GRCh38.p2 Primary Assembly GAGGTGCCCGCCCCGAGGCCCCAGCGCCACCTGCCCTCCACCACCTACCGCGGTTCCTCCAGCTCCCAGG GCCGCGGCCGGAGCAGCTCTGAGCGCTCGGTTCGCCCCACGGTGCCCTTAAAAGGCGCTGGCGCGAACCA ACGAGTCCCTGAGGAGAGTAGGGGGACAGCTCCGGCTCGCAGAATCCCCCCAAGCCACCCATGGAGGGCG CAGCTCCGTGTCGTGTCTCTCTCAAAGTGTCTCTCGGACAGCGCTGTTGGGAACGAGCCTGGCGCTTTGA TTTAGGGATGGGGGTGGTTTCCTCACTAACGAGTCACCCCCTCCAAAATATCGCAGAAAGTGGACGGCCC CAGTTGGAGGCACATCTTGAAACCCGCGGGGGAGGCCATGTCGGAAGAAGGTAAACAAAGGCATCGCCCC TGCCCTCCCTCCCTCCAACGGCCCAACTGCAGCCTCCCACTCGGTTCGGGCCGCGTCACGCAATTAGCCA CAGTGCCCCTCACCTGCTCTGCTGCCCCGCCCTCCACGACCACCTCTTCGAAGGAATCCCCCTTCCCCCA GCAAAGGACCCGTCCGCGGCGTGAAGGCTGCTGGGAAGTGTGGTCCAAGCGCGGATTAGGGCCTGCTCGG AGTCCCAGGAGCCCCTCTTGCAGCTGCCGGATCGGCCTGAACCTTAAAAACCCAGGACTTATAATGGTTG CGGGGACGTTTCCACTTGGTTCTGTAATTTGCCCTCACCCAGAACACTTTGTAAAGCTCAGGATAGCCCA GGGCTGTTCACTCCCTCTCTTCTCTCTCCGCCCCCTCCCCCCCAGCAGGATGAGGTAATGGGATTGTGAT TATGACATCATAGGCGGTTCAGTTGCTTGCGTTTGCCTGGGGGGAGGTGCGGGGAGGTGGGGAGAAGTGC GGTGGTTAGACTTTCCTTAAACAGAAAGGGAAGGAGGAAACAGGCAGATGGGGAAAAGATGTTGACGGCG CTATATTTCCACTTCAGGAAGACAAAACCACCTTTTATTAAGTCTCCACCACTACCACCACCTCCCACAT GAGCCAAAATTTAAGTCTTTTTTAAAGAGATTGAATGTAGACGTTAGTGTGTGAAGAGGTTGGGTTGATG GTTTCTGGCTCTTATGTAAATTCGAGTCTCAGCTAGCATCACAGATGGTTTAGGGAGACAAGCAAAAAAG TGGATAAAGGAGAGGCTTTAAACAATGCGTTCGTGTTGTGATCTCTTTGTAATACAAAGTTTTCTATTTC TTTTTTTTAATTGATTGGAAAGTAGCAGTAATGCAAGTAATCTTCACTATTACACTTAGCAGCAAGTCCT CTGAAAGACATCTGTTTTCTGTAAATATTTTGTGCCTTACTCAAGACTGGGACAGGTAAATAGCTGTGAT CAGCTGGAAAGTAGAGCCAGTGGCGGGGGTCGTCCTCACTGAGCCAGGGAGGGGAGGAGGCAGGAGCCAC CAAGTCTACAAACTGAAAAAGAGTAGAGGAAAAATGAGGTACAGTACTAACTGAGAAAATAGGGGTGGAA AGATTTACCTTGCACTGCTTATTTCCCCTTGGCAAAAGGAGCAGAGTTAGGGGCCATGAAGTAGGGGACA CATGGTTTCCAATAATTGCTCTTATGTACCAGACACCATGCTACATTTTTTTTTTTTTGTAAAAACAGGG TCTTGCTGTTGCTCAGGCTGGAGTGCACTGAGGCGATCACAGCTCACTGCAGCCTTGAACTTCTGGGCTC AAGCAATCCTTTCCATCTCAGCCTCCTGAATAGCTAGAACTACAGGGGTGTGCCACCATGCCCAGCATAT TTATTTCTATTTTTGTAGAGAGAGGCGTCTTGCTATGTTGCCCAGGGTAGTCTCAAACTCCTGGCCTCAA ACAATCTTCCCATCTTGGCCTCACAAAGTGCTGGGATTGGCGTGGTGTCTCACACCTGTAATCCTAGCAC TTTGGGAGGCTGAGGCAGACGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCAACAAAGTGAAAC CCCGTCTCTACTAAAAAATACAAAAATTAGCTGGGCATTGTGGCGCCCATCTGTAATCCCAGCTACTCGG GAGGCTGAGGCAGGAGAATCGCTTGAACCGGGGAGGCAGAGATTGCAGTGAGCCGAGATTGTGCCACTGC ACTCCAGCCTGGGCAACAGAATGAGACTCTGTCTCAAAAAAAAAAAAAAACAAATGAACAAAAAACGAAG TGCTGGGATTCCAGGTGTGAACCACCACACTTGACCTACATACTTTGATATATATTCTCATTTTTTCTTA CAATCATCAAATGAAACAAAACCTTCTCTTTGACAAATGAAACAGCCCAAGAAGTTAAGTGACTGCCCAC ATGGTAGGCAAAGGTACTCTCAAAAAGCAGTCTAAAAGCCCTTGCTTTTCACCACTAAGCTGTTCACCTT TTTATTATTAATTAAATTAATAATTTAATTATTATGAATTAAATGGTTGAGTTAAAAGTAGGCATTGGCT CATTTGCAAAACATTGAAAGAAACTGAGACCCAAAACAAAACAAAAAAAACAAAACAAAAAAAAAAACCC TGCAAGTCAAGTTTCAGGCCTCATTTCAAAGGAAGGTTACATCCCCTTTCGTCATCTATAAAATGGCCTC CCAGTGCAGCCCAACACTCCTACCCATAATTAAATCTCCTTATTCCACTTTTAGTTCCCAAGGATTTTTT ACTCATGTCCTGCTCTTTCCCTGCTGCCCCCTTTTTAGTCTTTTGTTCTTGAGCCACTGCTTTGAACTGC ATCTTAATTATGCCCTCATGGGCCAAACCCCATCTGTGACCCTGCTCCAGTGGGTTTCAGCAAAGGATAC TCTCCATCCATATTCTGAGGGCTCCAGGGCCTGGAGCCAGTCATCCAGGAGGTCATCCAAAGGAGTGGAA TCCATTGGTTCTAAGACTCTTCATTCCCTGCCTAGGAAGGAACAGCCGAGTTGGAGGAACATGCACTCGA TTCAGACCTTCCCTTTTCACCCAGTGAAAGCTAAACCTCTGCAAAGTGGGGAGAAGTAGGGCTAAGCCTA CCAGTCATAAAAAGAACCAGGAATAGAAAACACACCCCTCAGCCCCTCTGCCCTGCAGAGGCTGGCTGGG AGGATCCCAGGAATGCAGGGCTCTTCTCCACTGCCTGATCTGGGCATCCCAGGAGTGATGGCTGTACCTC CTGTTCTTGTTTGGTGTTTCAGGGTGAAGCCCGGGCTGTCACTGTGCCCTGGCAACAACATGTATGAGTC AGACTGAGGTCAAGGTGAAGGAACACAGCTCACTGCTTATCACAGTGAATCAGGAGCCTAGATAGGGATT CCCCAAGGATGACATAGGATCAATGCCCTCAATCCAACAGAAAAAGTAAATCTTCAAATCAGATTAAACA CCAAACTTCCCACCTCCCTAATATTCTTTCTTCTGGGAAGGATAACTTAGATATATTCCAACACCCTCAT AAATCAAGATATAAAAGACAATATTTGACTTCCCTTTAAAATAATTCTACCATTTCACAGTTTGTATGTA TGCATGTAAACTTACATGTAATTAGCTAAGTATGTTGCAATTAGCTAAGCCAGCTGGAATCATGAGGAGA TAGTGAAAATGTTTGCTAGGAAAACAACCTCATTAACAAACGTAGAGCTTTTAAGAGTTTTGTTGGCTGG GCATGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATTACCTCAGGTCAGGA GTTTGAGACCAGCCTGGCCAACACAGCGAAACCCTGTCTCAACTAAAAATACAAAAATTAGCCAGGTGTG GTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAAGAGAATCACTTGAACAGAGGTTGCAG TGAGCTGAGATTGCGCCATTGCACTCCAGCCTAGGCAACAAGAAAGAAACTGTCTCAAAAAAAAAAAGTT TTTTTGTTGTTGTTTTTAGGAGACAGTCTCACTATGTTGCCCAGGCTGGCCTCAAACTCCTGGGCTCAAG TGATCCTCCCAAGTAGCTGGGACTACAGGCGCACCACTGCATCTGTAAAAAGTCTTAAGGGCGGCCGGGC GCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCATTTGAGGTCAGGAGT TCCAGAACAGCCTGGACAATATGGTGAAACCCCACCTCTATTAAAAATACAAAAATCAGCCAGGCGTGGT GGCGGGCACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATAACTTGAACCCAGGAGGCAGAG GTTGCAGTGGGCCAAGATTGCGCCACTGTACTCTAGCCCGGGAGAGAGCGAGACTCCATCTTAAAAAAAA AAAAAATACTCTTAAGAGCTAGGTGTATAAGTTCCATTTGAGAAATCTCAGAAACTTATTTTTGGGGCTA GATTTTTGGAGAATTTGTTTTAGGAATGCTGCAACTTTGTCAGAGTGCTCAGATTTTAGTATATTTCCAT CACCTGACATTGAACTAAAGCCACTTGGCTGACACCTTTGTTGTGACCACCCACAACTGCACTTACTTGA GGACCTGGTGCAGAAAGCACTGGTAGCCAGGTGTGCACTTGCCATAATCTATCTGCTTTTGCCACCAATA GAGAATAACTTTGTCTCTACTTCCCACCTGCAGGGAAGTATACAATTTCCCACAAAGTGTGATTATACTG TAGTCGTCAAAGCAGATAACAACTCATCCCACACTCCCTTAATCCCCAGCCTGATTTTCAAACTCACCTG GCATAGCAAGGTTCTGTGCTAACTCCTACACTCACTGTCTGTATCCTAGAGGACAAAGAATCTTCACACA TCTCCTTTCTGGGGAAGCAGGTTCTGCAGATGAAAAGGGTATTAGGATAAAAACCAGCTGGCTACACTGT GCCTCTCAGCCACTACCACCACCAAGATCCTGACAACAGACACAAGTTGCATTTTGACTTTTGTTTCTCA AAGCATGATCTGCAAGCCGTCTGCATGGGTAGCACCTGGGGGCCTTGATAATGACCCCACTTTAGACCTA TCGAATTATCGTTTTTGGAGCCTACATCTTAAAGAGCTTCCAAGGTTATTTTGAACATTTTTATTATGGA AATTTTCAAATATACATTGAAGTAAGAAGTATGGGGTAATACCTTACCACGCAAAGTATGGTCGTAGGAC CAGCTACCTCACCATCAGCTGGGGGCTTGTTAGAAGGGCAGAATCTTGGGCCGCAACCGCAACCCAGACA TCCCGAATCAGAATCTGCATTTAGCAGGTCCTCAGGTGGTTAGTGTGCAAATTAAACCTTGAGAAGCACA GATATGATGGACCCTCCTGCCCCCATCACTCAACAGTCAGGGTCAATCTTGTATCATCAATACCTTCCCC CAGCACAGGATTATTTAAAAGCAAATCCCTAACATTAGGAATGTCTTTTTGTTTGTTTCACTCTAATGCC CAGGCTGGAGTGCAGTGGCGCAACCTCTGTCTCCCGAGTTCAAGCAGTTCTCATGCCTCAGCCTCCCAAG TAGCTGGGATTACAGGTGTGTGCCACCACAACCGGCTAAATTTTGTATTTTTAGTAGAGACGGGGTTTCA TCATGTTGGCCAGGCTGGTTTTGAACCCCTGACCTCATGTAATCTGCCCGCCTCGGCCTCCCAAAGTGCT GGGATTACAGGTGTGGGCCAACGCGTCCGGCCAATAATTTATAAATATCACCTCGTCAATGTTCAAATTT TCATTAATAACCAATCTTTGAGGTCCTCTGGATTGCGATAAGGATTATACCAAGATGATTTAATTCCTCC ACTTTCCCTGCAACGGAATTTCTTTTTACCCACGTGAGCTAGAGTCTCTGAGATGCTGCACACTAAAAGA AACACCAAACAAAGCTCTTGGAAGGGGCTAATGCCTCTCAGCATAAACACACACACCCGTCTCGCCCCAA CACTTGCCACGCCGGCAGCAAACGCTCCATCTCCCGTGGAAGGCCAGCAAAACTTAGAAGAAAACGTCCG CGAAAACGGCACGAGAAAGAAGCGAAGAAAATGAAACGCTTACAACACCCTCCACCCAAAATAATCTCTC CTAGTATTACCCTAGTGAATGGACATCACTAGTAAGGCGCGGTTTAAATCTCCCGGGGTTCGTGGGGCTG AGGGAACGAGGAAAACAGAAAGGGTGTGGAGATTGGTGAGAGGGAGAGCCAATGATGCGCCAGGCTCCCC GTGAGGCGGAGCTTACCCCGCAGCCTGCCTAACGCTGGTGGGCCAAACACTATCCTGCTCTGGCTATGGG GCGGGGCAAGTCTTACCATTTCCAGAGCAAGCACACGCCCCCAGGTGATCTGCGAGCCCAACGATAGGCC ATGAGGCCCTGGGCGCGCGCGCGGAGATTGGCTGACGCAGCTTAGAGGCGAGCGGGGATAGGTTACTGGG CTGGCGGAAGGTTTGAATGGTCAACGCCTGCGGCTGTTGATATTCTTGCTCAGAGGCCGTAACTTTGGCC TTCTGCTCAGGGAAGACTCTGAGTCCGACGTTGGCCTACCCAGTCGGAAGGCAGAGCTGCAATCTAGTTA ACTACCTCCTTTCCCCTAGATTTCCTTTCATTCTGCTCAAGTCTTCGCCTGTGTCCGATCCCTATCTACT TTCTCTCCTCTTGTAGGCAAGCCTCAGACTCCAGGCTTGAGGTAAGTCCGCAGCCGTCTCCGCCACGGAA TCACGGAGACCCCATTGTCCCCCTTAGGGTCCAGTCGGGCCCCCACAGACAGAGGTTGGGAGGGCCGAAT GGGGACTATCGCGAGTTACGAGACCCGGGTTCTTTCTAGTCAGGAGTCTCGAGCTGTGTGGCGTGGAACA AGTCAAAATCCTCTCTTCATTCCATCTTTAAGGTCCTAAGGTTGCCTCTCGTCGGTGAATTCAGGTTCTA ACCTTAAGCCAGGCTGTGAATCACCCTTCGGGGTTGCCCCTCTTCCAGTGTTGATTCGCCTGGCTGGAAA GGGTGGAGGAGTTTAGGAAAGCTGAGGGAACTGTGATGTACCGATTTAGATGACGTTTTCCTCCTAGCTA GGTTTTGTTTTTCTCCTGGTGAGAATTCGAAGACCATGTCTACGGAACTCTTCTCATCCACAAGAGAGGA AGGAAGCTCTGGCTCAGGACCCAGTTTTAGGTCTAATCAAAGGAAAATGTTAAACCTGCTCCTGGAGAGA GACACTTCCTTTACCGTCTGTCCAGATGTCCCTAGAACTCCAGTGGGCAAATTTCTTGGTGATTCTGCAA ACCTAAGCATTTTGTCTGGGTAAATATACTTTTATTTTTACACTGTATTGCCTTTGCTATTTCCAAACAG TTGGGTTTGTTTGTTGGTTTGTTTTCAATTATCCCGGCTCAAAGGTCAGGCTTTAAGTCTCAACTCTGCC CTTGACTGTGTAACCCTTTTGAGTCTCACCTTCTTTTCTGTGACAAGAAATAATCTCAGCCAGGCGAGGT GGCTCATGCCTGTAATCTCCGCACTTTGGGAGGCCAAGGAGGGCGGATCGCCTGAGTCTAGGAGTTCAAG ACCAGCCTGGGCAACATGGCAAGACGCCGTCTCTACAAAAAATATTAAAAGTTAGCTGAGTGTGGTGGTG TGCACCTATAGTCCCAGCAACTCGGGAGGCTGAGGTGGGAGGATTGCTTGAGCCCGGGAGGTGGAGGCTG CAGTTAGCCAAGATCGCCTCACTGCACTTCAGCCTGGGAAACAGAGTGAGACTCTATCTCAAAAAGAAAA GAAAAGACAAAGAAATAATAATCGCTTCCTATCTTACTAGGATCTTGTGAGAATCAAATGATGTGATAAC TGGGAAAAGTCTTTGAAAACCGCTGCATTACGAGTCGGTCACTTTATTAGTATTAATATTAGTGTTATTG CAGTTGTACTTTGAATTCTGATCATACCATGTCTCAACTAGCAAAGAGAAGTAGTACCTGAGAAAAACTA GGGACCCCAGGGAGAAATCAAGCCTGTGTTCATAGTGCTCAGGACCGGGAATGTGGAGTCAAGATCCCCC TCGGCCAATAAACTCTGGGCCTCATTTAAAAAAAAAAAAATTATCTGTTTCAGTATGTTGGTAAGGAGAA AATAAAGTACAGATTATGGTAGTGGGAGATTTTTCTCAGCCCAGTCTGATATATTTCCCAAAAGCAATTA GATTTATTTGGACACTGTTCAGATGATCTGATAGTCATTAAGGGGTGTTTCAAATGAACAGGCTTGGCCA GGCGTTGTGGCTCACACCTGTAATCCCAGCACTTTGGAAGGCCGAGGTGGGTGGATCACCTGAGGTTAGG AGTTTAAGACCAGCCTGGCTGACATGGTGAAGCCCCATCTCTACTACAAATACAAAAATTAGCTGGGCGT GGTGGCAGGCGCCTGTGATCCCAGCTATTTGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCG GAGGTTGCAGTGAGCCAAGATCGTGCCACTGCACTTGAGCTGGGGGGACAGAGCAAGACTCCACTGCAAA AAAAAAAAAAAAAAAAAAAGAAGAGGATGACATGATCTTTGACTTTTAAGGATATAATAATCTAATGGGA ATTTCGATGTACTATTATGTCTCAACAGAGGAACCCCAAAACGTTGCCTCGATCTTTCGAATCTTAGCAG TGGGGAGATAACTGCCACTCAGCTTACCACTTCTGCAGACCTTGATGAAACTGGTAGGGAGAAGGGAGAT AAAGGCCTCAAAGGGAAGAATAACTTTTAAGGGAGAAAACAGGGAAGGAGGATAGAGACGGAAGGTGGTG AAAGTATAAAAAGAATCTGCCTAGAGAGATGGAATTTTGTGGGTAACTAGAGGATTTTTGAGAATGATTA AGCCAATGGGAAGAGAAAGATAATAACACTAATAGGAGCTACTTTGCATATGAAAATGTTAGACAAGTAG GAATATATTTTGTTGACTGATTAATGGTGGGAATGAAAGTATAGTCATTAGGATATGAGAAGTTTTGTGC CTCAGTCTAATCTCAGCAGAGGCAAAGAAACCAGCATAAAGAAATATGTTGTTGGCCAGGTGCAGTGGCT CATGCCTGTAATCCCAGCACTTTGGGAGGGCAAGGCGGGCGGGTCACGAGGTCAAGAGATCGAGACCATC CTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAGTTAGTTTGGCATGGTGGCACGTGCCT GTAGGCCCAGCTACTGGGGAGGCTGAGGCAGGAGAATCTCTTGAACCCGGGAGGTGGAGGTTGCAGTGAG CCAAGATAGCACCAATGCACTCCCGCCTGGCGACAGAGCGAGACTGCATCTCAAAAAAAAAGAAATATGT TGTCAACTAATTTTTATATGTTTTATATGAAATATTCCAAAAGGAATGTTTCATAAGTTAACCTTCCAGA ATTCTAATTTCAGATTTTCTGAGTGATAACCTTTCTTTTCTACCCATAAGAAAAAAAAAAACTCCATAGG TAGCATAGTGTAGTGTTTCCCAACACTTGATTTCTTTTAGTGACACATATAAATTCTTACGTTTCTGTGA AATTGTACCTTGTACCATGAAATGGGTACCAATCGAGAGGCTTTGTATTCAAAAGCTCAGTCCTTGAAAT TAATACGGCTTACTGGTAATGAAGAAAATCTGAAGGAAAAACAGGATGCATGGACAAGAATAACTCCTTT TACTGATTCTTTATATTTGATTGCAGGTCACCTGGATTCTTCAGGACTTCAGGAAGTGCATTTAGCTGGG ATGTAAGTTCTGTTGTTAAATGAACCCCACACAAAAGCCTTTTAGCACTGGTCATAGAGATTTTATCCTG TGCAGACTCTGCAGAGTACAAAACCTTTCATACTGGGTATAAGTGGGCTTTGAGGCCTAGTTCCTTACCT TGAACAGTTTCTAAGTTTTCCACATCTAAATAGTGTTGTGAAAATGAAGGCTATTCATTTTAACCATCAT AATCAGAAGTATCTATAAGGAAATGAAGGAAAATGGTATACTACACTTATGTATAGGCTTTTATTTGTAT GTGAAAGGTGCTGTATCTTAGTAATTGAAAGTACAGAGTGGCCGGACACGGTGGCTTACATCTGTAATCC CAGCACTTTGGGAGGCCAAGGCAGGCGGATCAGTTGAGGTCAGCAGTTCAAGACCAGCCTGCCCAACATG GTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGATGTGGTGGCACATGCCTGTAATCGCAGCT ACTTCGGAGGTTGAGGTAGGAGAATTACTTGAGCCCAGGAGGCGGAGGTTGCAGTGAGCCAAGACTGCGC CACTGCCCTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAGAAAAAAAAAAAAAAAGAAAGTACAGAG TATAAGCTCTGGAATCAGTGTGTGGATTCCTGGCTTACTACTTCATTCACCAGTTGTGACTCTGACAAGT TTTTTTTAACTTCATTGGACCTTAATTTTTTTTATTTGTAACGTGGAGACAATAATAGCATTTCTCATAA AGTAGCTATTGTAAGGAGTAAATAAACTGTGTATCTAGCACATACCAAGCATTTTACTTATGTATTTATT TTTATTTTTGAGATGGAGTCTGGCTCTGTTGCCAAGGATGGAGTGCAGTGGTGCCATCTTGACTTACTGC AACCTCTGCCTCCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTC CACCACCACGCCCGGCTAATTTTTGTATTTTAGTAATACAAAAATGGAGGCTTCACCATGTTGGCCAGGC TGGTCTTGAACTCCTGACCTCAAGTGATCAGCGCCCCACCCCCACCCACCCCTTGGCCTCCCAAAGTCCT GGGATTACAGATGTGAGTCACTGGGCCCAGCTTGAATTGCTTTAAATGCTCTAACCCAGATAGATAATGA AATCCATGGAGGGAGGATAGAAATTAATTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGCCAGGA TGGAGTGCAGTGGTGCGATTTTGGCTCACTACAACCTCCGCCTCCCGGGTTCAAGTGATTCTCCTGCCTC GGACTCCTGAGAGGCTGGGACTACAGGCACATGCCACGACGCCCAGCTAATTTTTGTATTTTTAGTAGAG ACAGGGTTTCACCATGTTGGCCAGGACGGTCTCTATCTCTTGACCTCGTGATCCGCCCGCCTTGGCCTCC CAAAGTGCTGGAATTACAAGCGTGAGCCCCCGCGCCCAGCCTTTTTTTTTTTTTTTTTTTTTTGAGACGG AGTTTTGCTCTTGTTGCCTAGGCTTAAGTGCAATGGCGCGATCTCGGCTCACCACAACCTCTCCCTCCCG GGTTCAAGCGATTCTCCTGCCTCAGGCTCCCAAGTAGCTGGGATTACAGGCATGCGCCACCATGCCTGGC TAATTTTGTATTTTTAGTAGAGACGGGTTTCTCTGTGTTGGTCAGGCTGGTTGCGAACTCCCAACCTCAG GTGATCCGCCTGCCTCGAACTCCCAAAGTGCTGGGATTACAGGCGTGGGCCACAGCGCCCCGCCAGAAAT TAAATTTTTTTAAAAAGTTAGCCCCGGCCGGGTGCGGTGGCTCACATCTGTAATCCCAGAAGTTTGGGAG GCTGAGGCGGGCGGATCACGAGGTCAGGAGATCAAGACCGTCCTGGCTAACACGGTGAAACCCCATCTCT ACTAAAAATACAAAAAATTAGCTGAATGTGGTTGCAGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAG GCAGGAGAATGGCGTGAAACCGGGAGGCAGAGCTTGCTGTGAGCCGAGGTCGTGCCACTCCAGCCTGAGT GACAGAGCCAGATTCCGTCTCAAAAAAAAAAAATTAGCCCCAATACACTGTGCTGGAAAATTAGTAAATT GTAAATTGTATAAAACTCGTTCATCTTTGGAACATGTTATATGGTTATGCAGGCAAAATGAGGGTCTTAT CCCCAGGATGTCACTTGAGTCTTGATATTTACCACAGAGAATACCCTATGTATTGTTGTTGGAAGAGACA TATCAACTAGGAATAGGGCTCCTAGAATGAAATAGAAAAATGTTGGGATGCACCAATCCACTGAAGAATA ATCAAACAGTATTTGGGACTAACCTGACAGGCAGTTTGTTTTAATCTGCAGGAATCATGACCAGCACCTA ATGAAATGTAGCCCAGTGAGTAGCCTCTCTTTTTTTGGGTTTTGTTTTGCTTTTCAGGTGGGAGGCAGAG GGTTTCCATTGCACCTGTGGCTTGAGGATGCTGGACGTTCTCAGCAAACTCTCTTTTTTAGGCACAGCTT CTTTGTAGCACTCCGAATGGTTTGGACCGTGGCCATAGAAAGAGAGATGCAATGTGTAGTTCATCTGCAA ATAAAGAAAATGTGAGTGTTTAATGGAAACCTAGATATATTGGCAGTTTTATTTTTTGAGTGAAGAAACT TGGTATCATAATGAGACATAGAACTGTTTATACCTCGTATGCTAGACAAGGAAACTGTATTACTATAGGG GAGAAAATTTCTTTGTTTTTGTTTTTTCTTATTAAAGTTTGGCCCTAGGACAGACACCCAGCTCCAAATC TTCCACAGTAGGTCATCATTATTTCTCATGTTCAGTTGATCATTTTGAGGACAAAAATTACCCTTACTGT AGTGTAAGGGATTTAGGAGTTTTTTGTTTGTTTGTTTGTTTGTTTTAACAGGTAGGGATAACTTGCATAA CTTGTTCATGGATTTTTTTTTACCACTTTACATGCAAGTGTAGATTAATTTCTTATTTCCCCCTTAGTCT AGCTTTTAAGCCCTTATTCCGAGGAGGCCATGGTACTTTTTATCTAAACCTTAGGCCATCCGTCGTTCCA AGTTAAATCTAGCCTCTCCGGAGCCACCTCATCACTAAGATAGTTCTGTATCTAATCCCTCATCTAAGCC CCTTTTCTAGACATCGTTTTTTCTTCCCTGCCTCCCATCCCTTTCCCCAAATCATTACCATAAAAGATAG CTGCTCTTCTTTTCTTACATTGACTTAAGATAAACTCATGTTTTCGGCTGTTCTTATCAGTTTTTTCTTG ATTTAATACTGTCCTTCTAATCTCCATTTATAATCACTTTTTATTCATTTATTTTTGAAACTGAGTCTCG CTCCATCGCCCAGGCTGGAGTGCAGTGGTGCAATCTCAGCTCACTACAACCTCTGCCTCCCGGGTTCAAG TGATTCTTGTTCCTCAGCCTGCCAAATAGCTGAGACTGTAGGCACGTGCCACCACGGCCCAGCTAATTTT TGTGTTTTTAGTAGAGACGGGGTTTTGTCTTATTGGCCAAGCTGGTCTCAAACTCCTGACCTCAAGTGAT CCACCTGCCTCGGCCTCTCAAAGGGCTGAGATTACAGGTGTGAGCCACTGCCTGGCCTATAATCACTTTT TTTTCTTTTTTTTTGGTGAGACAGAGTTTTGCTCTTGTTCCCCAGGGTGGAGTGCAGTGGTGCAATCTCG GCTCACTGCAACCTCTACCTCCTGGGTTCAAGCGATTTTCCTGCCTCAGCCTCCCACGTAGCTGGGATTA CAGGTGCGTGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGACCA GGATGGTCTTGATCTCCTGACCTCGTAGTCTGCCCTCCTCTGCCCCCCAAAGTGCTGGGATTACAGCCGT GAGCCACCATGCCCGACAGCATCAATATTTTTAAAGTTTTTTTTTTTCCTCTCCCTAGAAATAAGGGTCT CACTATGTTGCCTAGGCAAATCTTGAACTCCTGGGCTCAAGCCTTAAGGTTTTGATACTTTCTCCGATTC ATTTCTAAAAAAGTTACAAGAATTTACATTTTCATTAGCAATCCAAATCTCATAGAATTTACTTATTTAT TTATTTATTTATTTTGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCGCAGTCTCAGCT CACTGCAACCGCTGCCTCCCTGGTTCAAGCAATTCTCCTGTCTCAGCCTCCTGAGTAGCTGGAACTACAG GCGCATGCTGCCACGCCCAGCTAATTTTTTGTATTTTAGTAGAGATGGGGTTTCACCATCTTGCCCAGGC TGGTCTTGAACTTCTGAGCTCAGGCAATCCACTTGCCTCAGCCTCCCAAAATGCTAGGATTACAGGTGTG AGCCACCCTGCCCAGTCTTCTCATGGAATTTGTTTTTTTTTTTTTTTTGAGATGGAATCTTGCTCTGTTG TCCAGGCTGGAGTGCAGTGGGACAATCTCAGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGAGATTCTC TTGCCTCAGCCTCCTGAGCAGCTGGGACTACAGGCGTGTGGCACCACGCCCAGCTAATTTTTGTATTTTT AGTAGAGACGGGGTTTCACCATATTGGCCAGGCTGATTTGAACTCCTGACCTTGTGATCCACCCACCTCG GCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCATACCTGGACTTCTCATGGAATTTTTTAAAAAA TTACTTTCTGCTGAGCAGTCTAGTTTGAGGGAAAATGCTAATTAGGCCAGATGTTGTGGCTCATCCCTGT AATCCCAGCACTCTGGGAGGCTGAGGTGAGAGGATTGCTTGAGTCCAGGACTTTGAGTTCCCTAGCTGGG GAACACAGCAAGACCACATCTCTACCCCACCCCCCAACCAAAAAAAAGAAATGGCTGGGACTTGGTGGTG CATGCCTGTAGTCTCAGGTACTCTGGAGGCCAAGGCAAGAGGATCGCCTCGGCCCAAGAGCCTGAGGCTC CAGTGAGTTATAATTGGGAGGATTGCTTGAGCACAGGAGTCTGGGGCTGCAGTCAGCTGAGATGGAGACT CAGTCTCAAATAAATAATACACACACACATACATACATGGTAAAATAGTTTATTTTATGTTAAAAATAAT TAGCAGGCCAGGCATGGTGGCTCATGCCTGTAATCCCACCGCTTTGGGAGGCTGAGGCAGGTGGATCACC TGAGGCCAGGATTTGAGACCAGCTTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAATACAAAAATTA GCCAGGCGTGGTGGCACCTGGCTGAGAAACAAGAATGGCTTGAACCTGGGAGGCAGAGGTTGCAATGAGC TGAGATTACACCACTGCACTCCAGTGCAGTGAATGGACAGGTGACAAAGTGAGACTGTCTCAAAAAAAAA AGGAAAAAAAAATAAAAATAAAAATAATTAGTAGTGGCTGGGTGCAGTGGCTCACACCTGTAATCCCAGC ACTTTGGGAGGCTGAGGCAGGCTGATCACTTGAGGTCAGGAGTTCCAGACTAGCCTGGGCAACATGGTGA AACCCCATCTCTACTGAAAAAAAAATATGAAAATTAGCCAGGGCCGGGCGCGGTGGCTCACGCCTGTAAT TCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACGAGGTCAGGAGATCGAGACCATTCTGGCTAACATG GTGAAACCCCGTCTCTACTAAAAATAGAAAAAATTAGCCGGGCATGGTGGCGGGTGCCTGTAGTCCCAGC TACTCTGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCGTG CCACTGTACTCCAGTCTGGGCGACAGAGCGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAT TAGCCGGGCGTGGTGGCAGGCATCTGTAATCCCAGCTACCCAAGACGCTGAGGCAGGAGAATCAGTTGAA CCCAGGAGGCAGAGGTTTCAGTAAGCCGAGACTGCACCACTGCACTCCAGCCTGGGCGACAGAGCGAGAC TCTGTCTCAAATAATAATAATTATAGGCCGGGTGCTGTGGCTCACGCCTGTAATCCCATCACTTTGGGAG GCCGAGGCAGGCGGATCACAAGGTCAGGAGATCGAGACCATCCTGGCTAACATGGTGAAACCCTGTCTCT ACTAAAAGTACAAAAAATTAGCCAGTCGTGGTGGCGGGCGCCTGTAGTCCCAGCTACTCCGGAGGCTGAA GTAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCC TGGGCGACAAAGCATGTCTCTGTATCAAAAAATAAAATAAAATAATAATAATAATTAGTAGTGATTTCAT GTGATTATTATCCATGCGTAATTTCTCTAGTGTCTTTTGTGCCCTTATAATACTGGGGTCTTAACTTACC CAGGCATTGACTTGCCTTTCATAGACCATGGACTCCAGAGATTTGGATTATTATTTCTAATCTCAACCCT GAGGGAAAGCTATTTTAACATATTCTATCCTATGAAGATAAAGTTGATCATGGTTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTGAGACAGAGTCTTGCTCTGTCACCAGGCTGGAGTGCAGTGGTGCGATCTCAGCTC ACTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCCACTGCCTCAGCCTCCCCAGTAGCTGGGACTATAGG CGTGCACCACCACACCCAGCTAATTTTTTGTATTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGAT GCTCTCGATCTCCTGACCTCGTGATCCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGC CACCGCGCCTGGCCACTAAGTTGATCATGTTTTATTTAGGTTTTTGGTTTCTAGGATGGAGGGAAGACCT GGAGTATGTTCAATTATTGGATAGTCTTATATGTGATTTTTTTTAATTGCAGTAAAATGTACATAATATT TACAATTTTAACTATTTGTGAGTGTGCAGTCTAGTGACAGTAAGTATATTAATAATGTGAGACTATCACC AGAACTCATTTCCAGAATTTTTTCATTATTCAAAACAGAAGCTGTATACCCTTAAGTGATAACTCCCCAT CCCTGTTTCTGCCCAGCCAATGATAACCTCTATTTTCTGTGTCAGTGAATTTGACTATTCTAGATACCTC ATATGAGTAGAATAATATTATATTTTGTCCTTTCATGTGTGTGTGTGAGGTCTCACTCTGTCACCTCTGC TGGAGTACAGTGGCACAATCATAACTCACTGCAGCCTCAAACTCCCGGGCTCTGATTATTCTCCCACCTC AGCCTACCAAGTAGGTGGGACTGCAAGTGTGTGCCACTATGCCTGGCTACTTTTTTTTTTTTTTTTTTTT TTTTTTTTTTGAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCAATCTTGACTCACTG CAACCTTTATCTCCCAGGTTCAGGTGATTCTTATGCCTTAACCTCCCTAGTAGCTGGGATTACAGACGTG TGCTACCATGCCTGGTGAATTTTTTTGTATTTTTAGTAGAGACGGAGTTTCACCATGTTGGCCAGGCTGG TCTTAAACTCCTGGCCTCATGTGATCTGCCCACCTCAACCTAATTTTTTTGTATATTTTGTAGAATCAGG GTTTTGCCATGTTGCCCAGGCTGGTCTCAAACTCCTGGGTTCAAGAGATCCATCTGCTTCAGCCTCCCAT AGTGCTGGGGTTACAGGTGTGAGCCACTGCGTCCAGCCTATATTTTCATTTAGCGTAATGTCTTCAAAGT TCATCTATGTCATAGCATGTATTAGAATTTCATTTCTTTTGTATGTATATATCATATTTTGTTTATCCAT TCATCTGTTGATGGACATTTTGAGTTGTTTCCAACCTTTTGGCCATTGTGAGTAATGCCGTTATGAACAT AGGTGTACAAAATCTGCTTGAGTCCTTGCTTTTATTTTATTTTGTGTATTTTTTTTTTCCAAGATGGAGT CTTTGCCCTGTCACCCAGGCTGGAGTGCAGTGGAACGATCACAGCTCACTGCAACTTCCACCTCCCTGGT TCAAGCAGTTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACATGCTACCATGCCCGGCTAA TTTTTGTATTTTTAGTAGAGATGGGGTTTCAACATGTTGGCCAGGCTGCTCTCGAACTCCTGACCTCGTG ATCTGCTGGCCTCGGCCTCCCGAAGTACTGGGATTACAGGCGTGAGCTACTGCGCCCGGCCCCTGCTTTT AATTCTTTTGGGTATATATTCAGAAGTAGAATTGCTTGATTACATGATAATTCTACATTTAATTTTTTGA GGAACTGCCATGCTATTATCCATAGAATGCCTCTGCACCCTTTTACATTCCCACCAGCAATGCACAAACA CTTGTTATTTCTTATAATGGCTATCCTAATGGGTATAAAGAAGTATCTCTTGCAATTTTCATATGCATTT CCATAATGATTACTTTGTTGAGCATCTTTTGATGTGCTTATGGGCCATTTGTATATCTTCTTTGGAGAAA TGTCTATTCATGTCCCTTTTGATTGTTATTGTTGTTGTTACTGAGTTGTAGGAGTTCCTTATATATTCTG ATATTAATCTCTCATCAAATATAAGACTTGCAAATGTTTTCTCCCATTTTGTGGGTTGCCTTTTCATTCC CTTAATGGTGTTCTTTGATGCACAAAAGTTTTCCATTTTGATGAAGACCAATTTATCTGTTTTTTTCTTT CGTTACCTGTGCTTTTGGTGGCATTATCCAAATCCAGTGTCATGAATTTTTTCCCTTATCTTTTCTTCTA AGAGTTTTATAGTTTTAGCTCTTACATTTAGAACTTTGATATATTTTGAATAGTTTTTAATGTTGTCAAT ATACTTGACAGGACAATGGAAACTTGGTGGACAGTGAAATGAAATATTTGGGCAGTCCCATTACTACTGT TCCAAAATTGGATAAAAATCCAAACCTAGGAGAAGACCAGGCAGAAGAGATTTCAGATGAATTAATGGAG TTTTCCCTGAAAGATCAAGAAGCAAAGGTAAAGTGTTCTGTGGTAGTATCTTTGTATTCTTCATATTCCT TCATTCTGTTAAAAGAAGAACTAGACAAATTAAACTTAGGAGAGTTTATTTGAGCAAAAAAATAACTAGT GAATCCAGCAACCCTCATAGCCAGAACATGTTCAGTAAAACTCCAGTTTGCCATGTGGTCAGGCAGTATT ATGGACAGAAAATGGAAATGAAGTACAGAAAATAGAAGTGAGGTACAGAGACAGCCCAGTTGGTTGCAGC CTTGAGTTTGCCTTATTTGAACATGGTTTAAACAGTTGATTGCTTGTGGTTGACTGAAGCTCAGCTGCTG TGCTTTCCTGAGACTCAGCTTTTTGATACAAAAGTATACTTCTAAATTAGGCTTTCAGTTAGTTTAAGTA CTAAGTTAGGTTGCAACTTGGTATATAAAGACTCAAGTACAGAGGCATCCCCAGGCCAAATTTAGTTTAA TTAAGAATTCATTCTTCTTTTTTTTGTTGTTTGTTTTTTTTAAGACAGATTCTCGCTCTGTCGCCTAGGC TGGAGTGCAGTGGCGCCATCTTGGCTCACTGCGACCTCCTCTTCCCAGGTTCAAGCGATTCTCCTGCCTC AGCCTCTCGAGTAGCTGGGATTACAGGTGTGCACCACCACACCCGGGTAATTTTTAGTATTTTTAGTAGA GACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTAAACTCCTGGCCTCAGGTGATCTACCCACCTCAGGC TTCCAAAGTGCTGGGATTGCAAGCGTGAGCCACCATGCCCAGCCAACAATTCATTCTTGAATAAACATTT TATGCCTGATATGTATGAGTCACTCTACTAAATGCTAGAGCTACAGAGATCAACAAGATGTGATAACCTA TCTTTATTTATTTATTTATTTTTGAGATGGAGTCTTGCTGTGTCACCTAGGCTGGAGTGCAGTGGTGGTA TCTCAGCTCACTGCAACCTCCGTCTCCTGGGTTTAAGTGATTCTCTTGCCTCAGCCTCCCAAAGCACGCC ATCATGCCTGGCTAATTTTTTGTAATTTTAGTAGAGACGGGGTTTTGCCATGTTGGCCAGACTGGTCTCG AACTCCTGACCTCAAGTGATCTGCCCGCCTTGGCCTCCCAAAGAGCTGGGATTACAGGCATGAGCCACCA CGCCTGGCGTAACCTATCTTTAGACTGTAGGGTTACCTGACTGATAGGTTATCAGGTCACTACAGAAATC TTCTTACTGCTGGTGAACAGGTTCCAGTCAATAGTTTGAGTGGATCACCATCAAAGTAATCTAGGATAAG TAATGTCTCCAGGATAATGGTAATGTATAAATGTATAGAATATACCTAACATTACTTTTCAGGTATTTTA TAATACAGTCTTTTGTTTCCTTTTTTCTTTCCCATATCACTGATAGATATACCTGAAGCATGTGGGTTAT AGCCTATATGCTGATATGCCAAAGATAGTTTCTGAGGCATTTAGCTTTTTTTGGTTTTTGGTTTTTGGTT TTTTTTTTTTTTTTTTTTTTTTTAGATAGACAGGGTCTTTCTCTGTAGCCCAGGCTGGGGTACGTGGCAC AATTAAAGTTCACTGCAGCCTCAATCTCCCCAGGCTCTGGCAGTCCTCCCACCTCAGCCTCCAAGTAGCT GGGACTATAGGCACATGCCATCATACCTGGCTAATTTTTTGTATTTTTTGTAGCGATGTGGTTTCACAAT ATTGCCCAGGCTAGTCTCAAACTCCTGGACTCAAGTGATTCACACACCTTGGCCTCCCAAAGTGCTGGGA TTACAGGCATGAGCTACCATGCCTGGCCTACATTTAGCATTTCTAAATCAGCTTTGTTGCTTTGAAACAA GTAGGGCTATGGGTTTGTCTTTAAAATTTATTCATTTCACAAGGCCAGTATGGTATAGTGGAGTTAGAAC AGTTGCATTCTAGTCCTCATGCTTTTATTTTTTTTAATTATTTAATTAATTAGATAGGGTCTTGCTCTGC TCTGTCACCCAGACTGGAGTGCAGTGTTGAACTCCTGGGCTCAAGTAATCCTCCCACCTCAGCCTCCTGA GTAGCTAGGACTATAGGTGCATACCACCATGCCCAGCTAATTTTTAAAATTTTTTGTAGAGATGGGGTCT TGATGTGTTGCCCAAGCTGGTTTGGAACTCCTGCGCTCCAGCAATCCTCTTGCCTTTGTTGCGGGATCTT TAGGGTGTTGCTTTTCTGGCCAGAAACCTTTCTGCCCAGTGGTGCCTTTGCCTGAGTTGTTGTCCTGCGT CGAGGTAAGCAGACAAGTAGAGGGTTAGCAAGACGAAGAGAAGCTTTATTGAGTGTTAGAACAGCTCAGA GGAGACCCACAGGGGGCAGCTCCTCTCTGTAGGCAGTTTGTCTTATCCCGTATTCAGCTCTCAGCAGAGA GGAGGCCCTGGAGTGGGTGGCTCCTCTCTGCAGGCAGGTCCTCCCTGTTGATTTCCCAGCTTTCAGCAGA CAGCATAGCTCCTCTCTCCTCTTTGGTTGTCTGATCTTTTCTCCATCCTCTACCCTGCTCTGGCTGAGCC TGGGCCTTTTATGGACCTCAGAGGGGAGAAAGTGCTTCCTGATTGGTTCATGGACTGTGAGAAAAGGCAG CACAAATCCCCATCCAGTGGGTGGGACTAGCAGCCCGGTCCCCAGCCTTTAAGCCCTCCCCGTCCTGAAG GTGGGGACTTACAGGAACCTCCCTTCTACCCAGGAGCCTGTCTGTCTCTCTCAGCAGTCCATGGCACCAG GCTGCTCACACCAAGGTGCACCTAAAGGCCAGCACTGACCACCCTCAGTCCCTACTTGGCTTCCCCTCTT TTGCTTCTCCGTGCCCAAATTCTAGAGGGGGTCAAGGTGGCAGGGTGCTGCCCTGAGGGTGCACACACAG ATCCGCCCCCGGACTGTAACAGCACCTGGACTTGCCCCAACCCCACTCTGAGATTGGAGTGGGTGCCAAG AGCAGAGAGAAGTGGGGATATGGGGGTGGTGGGGAGGCCTTCCTGGGCCCCCAAGGGTGCAGGCTGCAGA GACTATTAGGTCCTGCACCTGGGAGGGCAGCTGCAGCTGCACCCGGGAAGGCAGGGATCCTGCCTGCTCC CGGCCCCCACAAGACCACAGGGAGGCTCGGATCTGCAGCCACAACTTGGGCGGCTGCAAGCCCACCCAGG AGGGCAGGGCTTCTGCCTGCTCCGTGGAACAGGAGGCCCAGGTTAACAGCTGCAGTTTGTGTAGCTCCAG CAGCACCAGGGGAGCTCCTGCCCCAACTCAGAAGGGGAAGGGCTCCCGCTAGCTCCATGGATCATGCAGC CCTATCCATACCTCTCTGCTGCAGCCAGTTTGATGACAGCAGCAAGCCCTCTGGAGTTGCAGCTGCCAAC ACCTTGGCCTCTCAAAGTGCTGGAATTACAAGTGTGAGCCACCGTATCCAGCCTCATTCTTTTATTTACT TGGTGGTATGACTGTTCACAAGACAACCACTTGACCTCAGTTTTTAATTTATAAAATGGAGAGCATGATA AAACAACTACCTCCTTAATAGGCTTGTTGTAAATAAAATATTAAAAGCAGTTTATGTCCTCATCACATAC ACACAAATGGTAACTGTGTGATGAAGGATGTGTTAATGAATTTCATTGTGGTAATCCTCATGTAATATAT ACGTAAATCATTATATTGTACTCCTTAAGTATATACAAATTTTATCATTTATACCTCCATAAAATAGAAA AAAAAATTTAAAGAGCAGTTTGTAATACAGTAGTCCTCTGTTATCCACAGAGAATACATTCTGAGACCCC CCAGTGGATGCCTAAAATTGCAGACAGTACTGAACCCTATATATACCATGCTTTTCCCTATGCATATGTA CCTGTGATGGAGTTTTTTACTTAGGCATAGTAAGAGATTAACAATAATAACTAATAATAAAATAGAACAA TTACAACAACATACTATAATAAAAATTATAGGAGGCTGGGCGTGGTGGTTTATGCCTGTAATCCCAGCAC ACTGGGAGGCCGAAGCGGGTGGTCAGGAGTTTGAGAGCTGCCTGGCCAACATGGTGAAACTCCATCTCTA CTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCATCTGTAACCCCAGCTACTGGGCTGGCTGAGGC AGTAGAATCGCTTGAACTTAAACCCAGGTGGCAGAGGCTGCAGTGAGCCGAGATCGCACCGCTGTACTCC AGCCTGGGCAACAGAGTGAGACTCTAACTCAAAAAAAAAAAAAAAAAAAAGTGCTGGCTGGGCATGGTGA GTCAGGCCTGTAATCCCAGCACTTTAGGAGGTTGAGATGGGCAGATCACCTGAAGCCAGGAGTTTGAGAC CAGCTTGGCCAACATGGTGAAACCCTGTCTCTATTAAAAATACCAAAAAAAAAAAAAAAATTAGCCAGGT GTGGTGGCGGGCACCTGTAATCCCAGCTACCCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTAGGAGG CAGAGGTTGCAGTGAGCCAAGATCGCTCCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTCTGTCTC AAAAAAAAAAAAAAAAAAAAAAGTGCTATAGGCTGGGAGCGGTGACTCACACCTGTAATCCCAGAACTTT GGGAGGTCAAGGTGGGTGGATCACCTGAGGTCAGGATTTCTAGACCAGCCTGGCCAACAGTATGAAACCT TGGCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCAGGTGCCTGTAATGCCAGCTACTTGGGAG GCTTAGGCAGGAGAATCACTTGAACCCAGGAGGTGGAGGTTGCATTGAGCCAAGATCACACCGTTGCACT CTAGCCTGGGCAACAGAATGAGACTCCATCTCAAAAAAAAAAAAAGGTGCTATGAATGACAGGACGATTT GAATAAAGGACAGCACTTTGAGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCT GACCAACATGTTGAAGCCTCGTCTCTATTAAAAATACAAAAATTTAGCTGGGCATGGTGTTGGGCACCTG TAATCCCAGCTACTCAGGAGGCTGACACAGGAGAATTGCCTGAACCCAGGAGGCAGAGGTTGCAGTAAGC TGAGATTGTGCCGCTGCACTCCAGCCTGGGTGCGACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAAAA GAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAAGGGACATAGGTGTTTGGGAGGATATTATTTTTGACT TTACCCTGAGTAACTGGAGAAATGGTGACAACAGTATAATGAATTTGAAAAGAAGGGTGGATTCAGCGGG AATAGATGTGTTCTGTTTTGGACATTGAGTTATAGATGCTAAGGAGGAAATTTAGATGGAAATACTAAAT GAGGAGTTGAAGCTATCAGGATGAGAAATGTACATTTCTGGGGCAGCTGTATAGAGGAGAAAATGGAAGC TAATGACTCTAAGTTTAAAGTGAAGAGAAAGGCTGGGAAGAAAGAGCAGTAGCCACTGTGGGACTGATAA TGAAGTAGACACATATAGGAATAATATTAGCCAGGAATCAGAAAGGAGAGATCTAGGACACAAATACAGG TGGCACATTTATATATTAATTCTTTTTATACATTTTTTGTTATGGTAAAACAAAATTTACAATTTTAATC ATTTTTAAGCATACAGTTTAGTGGTATTAAGTGCCTTCATTTTATTGTGAGTGTACTTACCCATCTCTAG GATTTTTTTATTACCCCAAGCAGAAATTCTCTCTTTTTTTTTTTTTTTTTTTTTTTGTGAGATATAGTCT TGCTCTGTCGCCCAAGCTGGAGTGCAGTGGCGCAATTTTGTCTCACTGCACCTCCACCTCCTGGGTTCAA GTGATTCTCCTGCCTCAGCCTCCCGCGTAGCTGGGATTCCAGGCATGCCCCACCGTGGCCGGCTAATTTT TTTTGTATTTTTAGTAGAGACAAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAATATCTGACCTCAGGT GATCTGCCCTCCTCAGCCTCCCAAAGTGCTGAGATTACAGGTGAGCCACTGCACCTGGCCCCCAAGCAGA AATGCTGTACCCCATAAACAATAACTCCCCATCTTCTCCCCCTTCCCCAGCCCCTAGTAACCACTATTCT ATTTTCTGCCCTCTATGAGTTTGCTCTAGGTACCTCATATAAATGGAATTTTATCATCCTTTTATCTCTG GCATATATCTCATAGTGTAATGTTTTCATTGGTAATCAGTGTTGTAGCATGTATCAGAATTTCATTCTCT TTAAAAAAAATCAGTTTTATGTTAAATTGTAAAATGCACATAACCTTTATCATCATAACCATTTTCAAGT GTATAGTTTAGTAGTATTACATACATTCCCATTGTTGTGTAACCAATCTCCAGAACTCTTTTAATCTTGG AAAACTGGCACTCTGTGCCCATAAAACAACTTCCCATTTTCCCCTTCTCCCAGCCTCTGGCAACCACCAT TCTACTTTCTATAAATTTGATTATTCTAGATATCTCTGATAAGTGGAATGATACAGGGTTTTTTTGTTTT GTAACTGGCTTATTTCAACTAGCATAATGTCCTCAAGCTTTATCTATGTTGTAGCATGTATCATAATTTC ATTCCTTTTTATGGCAGAATAATATTCCATTGTATGTATATATCACATTTTGTGACATTTGGGTTTCCAT CTTTTGGCAATTGTGAATATTGTTGCTATAAAAATTGGTTTACAAATATCTGTTTGTGTCCTTGCTTTCA GTTCTTTTACTTTTTTGGAGACAGGTCTCACTCAGTTGCCCAGGCTGCAGTGCAGTGATGTGATCATGGC TCACTGCAGCCTTGAACTCTTTGGCTCCAGCAGTCCTCCCTTCTCAGCCTCCCAAGTGACTGGGATTACA GGTGTGAGCCACCACACCTGGCCCTGCTTTCAGTTCTTTAGGGTATATACCCAGAAGTAAAATTGCTGGG TCATATGGTTATTCTGTGTTTAATTTTTTAAGGAACTCTCATACTGTTTTCATAGCAACTGTTCATTTTA CATTCCCACCAGCAATGCACAAGGGTCTCAGTTTCTCCATATCATAGCCAACACTTGTTATTTCCTGATT TTGATACTATCCATCTGATGACTACGAAATGGTATCTCATCGTAATTTTAATTTGCATTTCCCTAATGAT TAGGGATGTTGAGCACCTTTTCATATGCTTCCTGGCCATTTGTATATCTTCTTTGGAGAAGTGTCTATTC AAGTCCTTTGCCCATTTTTTAATTGAGTTGTTTCTTTTGTTGTTGTTGAGTTGTAGTTCTTTATATATTC TGGATATCAATCCCTTATCAGATAAATAATTTGCAAATCTTTTTTCCTATTCCGTTGGTTGCCTATTCAC TATGTTGATTGTGCCCTTTGTTGCAAAAAAGTTTTTAATTTTGATGAAGTCTAATTTATCCACTTTTTTT GTTGCTTGTGCTTTTGGTGTCATATCTGAGAAATCATTGCCAGATTCAATGTCATGTGCCTCCCCCAACC CCCTCCCCTTTTTAAAAGAAAATAGTAGGGACAGGGTCTCACCCAGGCTGGAGTATAGTGATGCGATCAC ATAGCTCACTGTAACTTCAAACTCCTGCCCTCAAGGGATCCTCCCACCTCAGTGTCCATAGTAGCTAGTA CTACAGGCATGCACCACCACACCTGGCTAATTTATTTTTTGTAGAGATAGAGATGAGGTCTTGCTGTGTT ACTCTTCTGGTCTCAAAATTCTGGCCTCAAGCGATCCTCTTGCTTCAGCCTCCCAAGGTGCTGCGATTAC AGGTGTGAGCCATTGGGCTCAGCTCCCTATGTTTTCTTTAAAGAGTTTTATAGTTATAGCTCTTAAGTTT AGGTCTTTGATTCATTTCGAGTTAATGTGTGTATATGGTATAAGAGAAGGCTTTAACTTTGCTCTTTGGG ACAAAGAACAAAGCAGTGTTGGCTACAATATGGAGAAATTGGGACCCTTGTGCATTGCTGGTGGGAATGT AAAATCCAGTTGTCCCACCACTAATTGTTGAAAAAACTCTCCTTTCTTCATTGAATGGTCTTGGCACCCT TTTCAAAAATCATTTAACTATATATGCAAGAGGTTATTTCTTGGCTGTGTTCCATTCCATTGGTCTATAT GTCTGTCTTTATGCCAGTGCCACACTGTTTACTGCAGCTTTGTAGTAAGTCATTTTATAAATCTTTAATT TCACAAATCATCCTTGAATATATTCTCCTTTATGGAAAAGTTAAAACATAACAGCTAAGGATAACTAACC CTATCTGACCACCATTCGAAGTCCCTATTGAAGGAAAGGGCTCAGTGGGAAAAGTTAAGAGCATGTGAGT CAGTGGAGCGCAGTGGTCTGAGAAGTAGCCTCTGGGGCCAGACTGCCTGGATTCATAGCTTGACTCTGCC ACTTTTAGATATATGACTGTAGGTGAGTCATATGATCTCCTTGTGTTCAATTTCTTGGGTTGTTGTCAGG ATCGAATGAGTTAATTACACATAAAACATGTAGAGCAATACTTATCAATTAATAGTACTTAACTATTATT GTGTAGTGTAAGTGCTTAATTATTGTAGTATACGACTAAACTATGTGGAGTTATGAAGAAGGCTGATAGG TGAGGGGATGCTCAATGGCCTTGATGTCCTCCGCAAAGTAAACATTGAAGTAATCTGATGATTCAGAGGA GAGTGCGAGGCGAGAGTCTTAAAAGTGTGTGAAGAAGGTTATAATTGACTTTTGGAGACTGTGGAATTAC TAAAAGCCTAGTAAGATGATATTTGTAAGGTCCTATGAGGGCATTATCAGGTAGACATGCATGGCACTTG TTCGAAGTGTCTTCCTACAAGAATGTTCTGGCCTGGAAGCGAGATTGGAGACTTTGGAACTCCAGGGATG ATAGTAAGGGTTGAAGATTGCCAATGGTGGATGAACAAGGGGTTGAGGAAGAATAGGTATGGTGAAGGCA GCAGAAAAGTCGACGATGATTCAAAGCCTGGCTAAAAAGCCAGATATCATTAGGTGGACTCAGTAAAGTA AGAGCAGTAATGTGATTGAAAGTTGCTGAGAAGGTAGAAAGTGGCTGGTTTAGAAAGTTTTGAGAGCTAG GCTGGGAGCAGTGGCTCATGCCTGTAATCCTAACACTTTGGGAGGCCGAGACAGGTGGATCACTGGAGAT CAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCTCATCTCTACTAAAAATACAAAAATTAGCCGG GTTTGGTGGCAGGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGGGAATCGCTTGAACCTGAGA GGTGGAGGTTGCAGATCACACCACTGCACTCCAGCCTGGGTGACAGAGCGAGACTCCATCTCAAAAAAAA AAAAAAAAAATTTTGAGAGCCAGGGGAGGTTTTAGTTAGTTTGAGGGCATGCCATGTTTGAGCTCTTGAT AGTATAATAATAGATGATGATTGCAGTTGTTTTTATTTTTATTTTTTTATTTTGTTTTCTTAAATTCCCC TCACCTCCCCCCATCGCCCTTTTATTTTGAGACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGTGATG GTGTGATCTCGGCTCACTGCAACTTCCGCCTCCAGGGTTCAAGAGATTCTCCTGCCTCAACCTCCCAGGT GGGTAGGATTACAGGTGCCCACCACCACCCCCAGCTAATTTTTTGTATTTTTAGTAGAGATAGGGTTTCA CCATGTTGGCCAGGCTGGTCTTGAACTCCTGATCTCAGGTGATCCACCTGCTTTGGCCTCCCAAAGTGCT GGGATTACAGGCGTGAGCCACTGTGCCCAGTCAAATTTCCTGTTTTAAGAATGAAGTATTTTTATGTTTT TTTTTTTTTTTTAATACCAGTTTGTTGAGAGCCTGATGTGGAGTTCTAGAGAAGCTTAGTGGAAGTATTG TGAAGTCATGCTCTCCAAAGTGTTGTCAGTGGACATTGTAAGAATGTGGAAAATACAATGGGTTTTAGTA TTGAAGACAGTACAGAGACTAGAATGGAAAGGAAAAATGAGGGCCACGCAATAACAAGAGCTCCCATTTA TTGACTACTTAGAGTATAGTAGGCACCATGTGCTAAGCAGTATACATCCATAATCACATTTCATTCTCAT ATCCACCCTGAAATATGACTGTTGTCTCCCTTTGAGGGGAGCCCATTGGGTCATGAGGTAAGGTGTGATA CCCATGGTTACATAGTTAGAAGCAGCAGAGCCAGGGTTTAAACTAAGATCTACCTGACCCCAGAGCCTGT TTTTAGCAATTTTCCCAGGTAATTCTGATATACACTAAATTTTGAGCGTTATGTTCTATAACATAGTATT AAGTCCTATTTTATTTTTAATTTCATTGGTTTGTGGGAAAACAAAACCAAGATACAATCTGAAGAAGGCA GGATGGGTGTTGGGAGAATTGACAGTGACCTTCCTAAAACATAAAACAGTTTTGAGGACTTGCTGATAAT GGGCAGTAGATCTATAGAAAAACAGTGAGTTGGGAATAGTCGGCATGGGGAAAAGGTTTCTAGGGCTTCC GAAAAAAAGAGCAATGTAAAATGAAGATTTAGGATCACTTTTACAAATATGTTAGTCTTCACATTTGCAG AATGTTGTAATTAATATAGTTAAGTCTCAGCTGGTATTAACTTAGCAAATTGAATTTAATGTTAATTTAA AAAATCCTTTTATTTTCTATTTCATTGTTGAAAACTTGTCTAAGTTATGTTGATCTGCTTTTATGAAATT AAGTACAGTACAGTGAACATAATTGAATCTTTCTCTGGTGATTGAAGATCTTTCATAGTCTCAGAAATAT CATTCTGAATTGCATAATATAGACAGTATAGAAGCATGGACTTAAAATAGATTGACCCCAGGAAATATTC TGGAACAGGTTTTCCCAACCCGTGGGCCATGGATCAACACAGGTCCATGGCCTGTTAGGAACCGGGCCGC ACAGTAGGAAGTAAGAGGTGGGCCAGGCCAGCGAGCATTAACACCTAAGCTCTGCCTCCTGTCAGATCAG TGGCAGCATTAGATTCTCATAGGAGGCAAACTCTTTTGTGAACTGCGCATGCGAGGGATCTAGGTTGCCG GTTCCTTGTGAGAATCTGAGAATCTAACTAATGCCTGATGATCTGAGGTGAAACAGTTTCATCCTGAAAC CATATCCCCACCCAGATCCATGGAAAAAAATGTCTTCCACAAAACTGGTCCCCAGTATCAAAAAGGCTGG GGACCACTGCTCTGAAAGTTTTGTTTAGGTGGAAGAGTGGCATAGGGCTATGAGTATTTATTTGATTTTT GTTTTAAGAGACAGGGTCTTCTATATTGTCCAGGCTGATCTCAAACTCTTGAGCTCAAGTGTTCCCCCTG TCTTGGCCTCCCAAAGTGCATTTTGATGGTCTTTGAAAAATATTTGGACAATAGAGCCTTGACAGAAAAT TTAAATAATTAAATAAAAAATGTTTTAAAATTGTCCTTTTATGGGCTCATTTTCTTAGATTGTAACTCTT ATGCAGTCATTTTCTCTTTCTTTTTTTCCTTCTTTCTCTTTTTCTTTTTTTTTTTTTTTTTTTTTGTGGC AGTCTCAGTCTGTCTTCCAGGCTGGAGTGTAGTGGCGTGATCAGGGCTCACTGCAGGTCACAACCTCCTG GGCTCAGGCGATTCTTCCATCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACATGCAACCATGCCAAGC TAATTTTTGTAGAGACAATTTCACCATGTTGCCCAGGCTGGTCTTAACTCCTGGGCTCAAGTGATCTGCC TGCCTCACCCTCCCAAAGTGCTAGGGTTACAGGTGTGAGCTACCATGCATGGCCATAAAGTCATTTTTGA TTGATGGCCCATCCTATAAGAATATGCATAGCAGTAGGTTTTAGGTTACAAAAGGGATAGGGGGCTGGGC ACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGCAGATCCCTTGAGGTCAGGAGT TCGAGACCAGCCTGGCCAACATGGCAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGT GGCATGCACCTGTAATCCCAGCTACTAAAGAGCCCGAGGAAGGAAAATCACTTGAACCTGGGAGGCAGAG ATTGCAGTGAGCTGAGATCGTGCCGCTGCACTCCAGCATGGGCAACAGAGCGAGACTCTGTCTCAAAAAG GAAAAAAAAAAGAAAAGGAATAGGGATTTTTTTTTGTTACTGTTTTACCTCTTTGATGTTAAATGGAAAA AAAAAAAATAGGCCAGGCACATTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGA TCACCTGAGGTCAGGAATTTGAGACCAGCCTGGCCAACATGATGAAACCCCGTCTTTACTAAAAATACAC AAATTAGCTGGGCATGGTGGTATGCACCTGTAATCTCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCT TGAACCCGGGAGGTGGAGGTTGCAGGGAGCCGAGATTGCGCCACTGCACTCCTGCCTGGGTGACAGAGTG AGACCCTGTCTCAAAATATAATAATAATAATAATAATAAACGGAAATAAATAGATACTTGTATAAAGCAG TGACCTCCTTGGAGATTGTCGTAACCTTAGTGATTTTTCATTCATTTCTTTACTTAAAAAATATTTATTG AGTACTTGCTACATGTTGGGAAGTGTGCTAGGCACTGGTGATACGATGGTGAACAAAACAGACTAGAATT TATATTCTTGTCAGGGATGCATCAAAACAACAAAAATTTTTTTCAAGTTAATAGATATTCTAGTTAGAGT TCTTGGTTGCAAATAATAGAAACTGATTCTAGTTTCCTCAAGCAGAAAAGGGATTTTTCTGGAGGGTACT GAGGAACTCAGAATTACAAGGAAGGCTGGAAAACAAAGTAAGGCCCAGCCAAAATACTATTCCAGGAACA TTGAGCTCAGGATGCCACCACTTGCTGGCTAGACACTCAATGCCACCGTTACTGGCACCCTGCCATGGAA CATGATCAGGCTTGCTGCTAGATAGACTGTGCTGCTCATGGATATTTGCTACCACCTAGTATATTCTCTA CTGTGATGCAGCCACCATAAAAAGTCTGGACCAACCCTTTGCTTTTTGAGCTTCTTTAAGGTTGAAAATC CCAGGCAGGAATATCTAGTTGGTCACAAGGGCATGGAAAAGGGAATATCTGTCTCCCATTGGCCACCTCA TGAGGAGGCAGGACTGCCTCTCTAACTTTAGATTTTACTGAAACAGTATGTTAGGCAGCCAAATTGTAAA TGTCTGCCATAACAGACAAAATAATTTAGATTTTGGGCTGGGTGTGGTGGCTCACACTTGTAATCCCAAC ATTTTGGGAGTCTGAGGCAGAAGGATAGTTTGAGTCGACAAGTTTGAGACCAGCCTAGGCAACACAGTAA GCCCCCATCGCTACAAAAAAATAAAAATTAGCCAGGCATGGTGGTGTGCCCCTGTAGTCCTAGCTACTCC AGAGGCTGAGGTGGGAGGACTGTTTGAGTCTAGCAGTTCAAGGCTACAGTGAGCCATGATCATGCCTGGG CAATCCAGCCTGGGTGACAGAGCAAGACCCCATTTCTAATAATAATAATAATAATTTAGTAATTGCAAAT AGTCCAAGTGTAATGATGGAAACAAAATGAGGTCTGAAATAGAGGCTAACAAAAGGAAATCTTTAAATGG AGAATAATAAGGGAAGATCTCCACAAGTGGGAGATATTTGGTTAAGAATCGGGTGATGAACTCTCTGTTT GCCTGGGACTAGAATGTTCTAGGATATGGGGCTTCCATTGCTAAAGCTGGGAAAGTCCCGGACAAGCTGG TATTAAGTTAGGGCCACTCTAATTGTGAAGGAATCATATATGACAAGAGTAGAGGCAGGAGCATTTCATG AAGAAGGAATGTTGCAGGTACAGAGGCCCCAGGTGGAAAAGGTCTTCACATGTTGGAGGGACTGAGAAGT CAGTGAATGAGAGGAGTGTTATGTGAGCTGGGAAAGAATAAGTAGTCAGGAGGTAGATCACGCAGGGTCT TTAGGCTATGGTGAGTGTTTGGATTCTATTCTAAGTACAATGAGTTGCTACTGAAGGGAGGGCTTTAGGC AGGGGAATAATATGGTCTGATTTGTTTTGTGAAGACCACTCTTGTTGATGGATGGGGAACAGATTAGAAA GGATTAAGAGTTGGAAGTCAACGGGTGGTTTGGCTTTCACCTGTAATCCTGTCAATTTGAGAGGCTGAGG CAGGAGAGTTGCTTGAGCTCAGTAGTTTGAGACCAGTCTAGGCAACATAGCAAAACCTCATCACTACTAA AAATAAAAAAATGTTAGTTGCATGTGGTAGTGCATGCCTGTAGTCCCAGCCACTTGGGAGGCAGAGACAG TAGGATTGCTTGAGCCCAGGAGGTCAAGGCTGCAGTGAGCCATGATCGTGCCACTGCATTCCAGCCTGGG CAACAAAGGGAGACCCTGCCTCAAAAAGGAGAAAAAAAAAAAAAGAGTTGGAAGCAGGTAAGAGTAGGAG CCATTGTGTTAGTCCTAGCTACAGTTGGTGGTAGCCTGAACTAAGGTGTTGACTATGGAGACAGAGAAAT GGATGCATTCAAAATATATTTTGTCTGCCTGCCTCAGCAACATGTCTCTACAAAAAAAAAAAAAAAAAAA AAAAGCCAGGCATGGTGTGTATGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGTGGGAGGATGGCTTGA GCCCAGGGGTTTGAGGCTGCAGTGAACCACGATCACACCACTGCTCTCCAGCCTGGGCAACAGAGCAAGA CCCTGTCTCAAAAAAATTAAAAAAGTAAAAAGATACATAGATATATATATTTTGGATAGAGAATCAACAG GACTTGAAGGGTTGGGTGCAGGCTGTGAAGGAAGGATGAGATCAAGGATGACTTTAGTCATATGCAGTTT GAAGTGTTTTGTTGTGAAGAGAAAACAGATGCTATCAGAAGAAAACTGCCTTCTTTTCTCACCAGATACA GCAATCAATCTCCTTTTATACCCATATAATCTGCAGTCGCTCTTGCCACAGAGCACGAAGTGTCCCTGCT CCTATCTAAAGCCCTTCCTTCACACTGTGTCCTATTCATTCATTCATTCATTTATTCACTAATGCCAGAG ATACAGTAGTATCTGAGCTTACATTCTAGTTATGAGGAAACAGACAGACAAATACATTTGTAATATGGCA GATGGTAAAAATACTATGGTGAAAAAGCAAAGGGAGATTATAGGGAGTCCCTGGATTGGAGTAGGGCAGG GTGAGAGTTGTTATTTTTGATAGGTTGCATAGGTCAGAGGAGACTTATTTGAGAGTGACGTTTGAGCAGA CATCTGAAAGAGCGAGGAAGCCAACAAGCAGATGTCAGGAGGAATGAGTCATTCCCAGCAGAAGGCAAAG CAAGTGCAATGCCCCTGAGGTGAGTATGCTTGGCGTGTTTATGGGACAGCAAGAAGGCCAGTGTGGCTGA AGCGGAGGGAGCAAGTGGAGAAGGGTAGAAAATGAGGGCAGAGAGGAGTTAGCAGAAGGACAGATCGTGT AGGGCCTTGTAGGCATTTGTAAAGACTGCAAAAACCGAGTCAGATGGAAGCATCTCCTCATGTGTACTAC TGCAGTATTTCCCCACTCCTATATTACCAATTTTCCCTTCTACTAGAATAAGAGTTCTCAAATTTTTTGG TCTTAGAACTCCTTTGTAATCTTAAAAATTACTTACAACCCCTTGCCTTACACCTGAGCTTAGAGAAAAG CATTCAGCTTTTTATACATTGAGTATGATGTTAGCTATACATTTCTTGAGAAGCCCATCATCAGGTTGAG GAAGTTCCCTTCTATTTCCTAGTTTGCCAGGAGATTTTAGCAGGAACAGGTTTTTTGTTTTTGTTTTTGT TTTTAAAGAGACATGGTCTCACTCTCTTGCCCAGGCTGGAGTGCGTGGCACAATCACAGCTCACTGCATC CTCAAACTCCTGGGCTCAAGAGATCCTCTTGCCTATGCCTCCCCAAGTAGCTGGGACTACAGGCAAACAC AGTCACCCCTGGCTAGTTCTTTTTTTTTTTTTTCCCCTATAGAGATGGGGATCTCACCATTTTGTCCAGG CTGGTCTTGAACTCCTGGGCTCAGGCAACCCCTCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCAT AAGTTACCCTACCCAGCCCTTTTCTCTGTATCTATTGAGATAATCAAGTGAGTTTTTTTTTTAATCTGTT AATATGATGAATTACTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCTCAGGCTGGAGTGCAATGGT GCAATCTCAGCTCACCACAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAG CTGGGATTACAGGCATGTGCCACCACGCCTTGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCTCTAT GTTGGTTAGTCTGGTCTCAAACTCCCGACCTTAGGTGATCCACCTGCCTTGGCCTCCCAAAGTGCTGGGA TTACAGGTATGAGCCACTGTGCCTGGCCTACGTTTTTGAATGTTAAACAACCTTGCAATCCTGTGATAAC CTCACTTGGTTGTGACATATGATCCTTCTTATATGTTGTTGGATTTCATTGCTAACATTTTGTTGATAAT TTTTACATCGGCCGAGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGAT CACTCGAGGTCAGGAGATCGAGACCAGCCTGGCCAACATGGTGGAACCCCCGTCTCTACAAAAAAATACA AAAACTAGCCGGGCATGGTGGCACACACCTGTAGTACCAGCTACTCGAGAGGCTGAGGCAGGAGAATCGC TTGAATCAGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGTGCCACTGCAGTCCATCCTGGGAGACAGAGC GAGACTCTGTCTCAATAAAAAGGCCGGGCACAGTGACTCACACCTGTAATTCCCAGCACTTTGGGAGGCC AAGGCAGGTGGATCACCTGAGGTCAGGAGCTCGAGGCCAGCTTGGCCTACATGGTGAGACCCCATCTGTA CTAAAAATACAAAAATTAGCCAGGTGCAGTGGCACACACCTGTAATTCCAGCTACTTGGGATACTGAGGC AGGAGAAACGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATAGCACCACTGCACTCCAGCCTG GGTGACAGAGCGAGACTCCATCTGAAAAAAAAAAAAAAAATTTTTTTTTTTTTTTGTGTACCTCTATGTT CATGAGAGATATTGATCTTCAGTGTTTTAGCTTTTCATGTTAATGTTTTGGTATTGGTATCAGTGTAATG CTAGCATCATGAAATGATTTGCAAATAATTCCCTCTTTTTTTTTCAATTTTCTGGAAGAGTTTATATAGA ATTGGTTTTATTTCTCTTTTAGATGTTTGGCACGATTCACCGGTGAAGCCACCTGGGCCTAGAGTTTTCT TTGTGGGAATGTTTTTAACAAATTCAACTTACTTTACAGATAGGAACTACTCAGTTTAACTGTTTCTTTT TGAGTGAGTTTGGTAGTTTGTGTCTTTGAAGGAATTTGTCCATTTTAATTAGGTTGTCAAATATAGTGGC ATAAAGTTGTTAAAAATACTTCCTTATTAGCGTTTTAGTGTCTGTAGAATCCATAGTGATGTCTCTCATT CCTGATATTGGTTATATGTGTCCTCTGTCTTATTCCTGATAAGTCTGGGTAGAGATTTATCAATATTGAT CTTTTTAAAAAATCATCTTTTGGTTTTATTGACTTTCTCCATTGTTTTTCTGTTTTCTATTCCATTGATT TTGCACTCTAATCTTTGGATACTTTGAGTTCAATTTGATCTTCATGTTTAGTTAAGGTTGAAGCTAAGGT CATTGATTTGAGACCTTTTTAAATAAGGGTATTTAGTACTTTAGCTGCATCTCACAAATTTTGATATGTT GCATTTTCAGTTTTATTCAGTTCAAAATACTTTCCAATTTCCTTTTTTGGTTTCTTTTTTGATGTAGGGG TTACTTAGAAGCTTGTTATTTAATTATTTGCAAATATTTGAGGACTTTTTGAGGACCTCATATTTGAGGA CCTTTCTGTTATTGAATTCTAATTTAATTCGATTGTCAAGAATATATTTTATATGACTTAAATCCTTTTA GGTGCATTAAGATTGGTTTTTATGGTCCAGAGTATGACTCAGAACATCTTGGTAAATGTTTAGTGCAACT TAGAAAATGTATAGTCTCTATTCTTGAGTAGAATATTCTATGTATGTCAAGTAGGTCCAGTTTATTTATA TTGTTGAACACATCTATATGCTTATTAGTTTTCTGTCTATTAATCTATCAATTTTTTTTTTTTGAGACAG AGTCTCACTCTGTTGCCCAGAATGGACTGCAGTAGCACAATCACGGCTCACTGCAGCCTCAACCTCCTGA ACACAAACAATCCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGCACCACTGTACCCAGCT AATTTTTGTATTTTTGTAGAGACAGCGTTTTACCATGTTGCCCAGGCTGGTCTTAGACTCCTGAGCTCAA GCAACCCACCCGTCTTAGCCTCACAACGTGCAGAGATGAGTAATCATATGGTTTTTGTCATTTATTTTAT TGATCTGGTGGGATACGGTGGCTGATTTTCAGATGTTATATCAACCTTGCATTTCTGGGATACATCCTAC CTGGTCATGGTTTCAGTCTTTTGTTTTGTTTTGTTAATTGGAGTTGGGGCGGTGCCTCACTATGTCGCCT TGAACTCCTGTGTGCTCCAGCAATCCTTCCACCTCCGCCTCCTGAGAAGCTAAGACTACCGGTGCACACC ACTACACCTGGCTAGTTTCAGTAGTTTTTGTCTTGTTAGGAATTAGTCCATTTCATCTAAGTGGTCTCAT TTGTTGGCACACAGTTATTCACTAATATTTCTTCATGATCCTTTTTATTTCTGTAAGGTTGGTAGTAATG TCCCACTTTCCATTCCTGATTTTGATAACTTGAGACTTTTTTTTAATTGTTCAGGCTAAAAGTTTGTCGA TTTTTGCTGATCTTTTCAAAGAACCAACTTTTGGTTCTGTTGTTTTTCTATTCTCTTAAGTTCTGCTCTA ATCTTTTTTATTTCCTTCCTTCTGCTTGCTTTGGATTTAGTTTCCTCTTAGGTGGGAGTTTAGGTAATTG ATTTGAGATCTTCTTTTTTATTTTAGGCATTTATAGCTTTAAATTTTTTTCTAAGCATTACTTTAGCTGT ATCCCATAAGCTTTGGTATGTTGTATCTTAGTTTTCATTCATCTCAAAGTATTTTCTGATTTTCCTATGA TTTCTTCATTGACCCATTGGTTATTAACAAGTGTGTTATTTAATTTTCTTTTTCTTTTCTTTCTTTTTTT TTTTTTTTTTGAGACGGAGTCTTGCTCTGTCCCCCAGGCTGGAGGGCAGTGGTGTGATCTTGGCTCACTG CAACCTCTGCCCCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGTTGAGATTACAGGCGTA CCCTACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGGCTTCACTCTGTTGGCCAGGCTGGTC TCGAACTCCTGACCTTAAGTGGTCCTCCCGCCTCAGCCTCCCAGAGTGCTGGAATTACAGGCATGAGCCA CTGTGCCTGGCCTTTTTTTTTTTTTTTTTTTTCCAGACAGAGTCTCCCTCTGTAACCTAGGCTGGAGTGC AGTGGTGCGATCTTGGCTCACTGCAACCTGTGCCTCCCAGGTTCAGGCAATTCTCCTGCCTCAGCCTCCC GAGTAGCTGGGACTACAGGCACCCGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTT TCACCATGATGGCCAGGCTGGTCTGGAACTCCTAACCCCAGGTGATCCGCCCGCCTCAGCCTCCCAAAGT GCTGGGATTACAGGTGTGAGCCACCACACCTGGCCTATTTAATTTTCATAAATTTGCTAATTTTCCAGAT TTTTTCTGTTAACTGATTTCTAATTTTATTCCATTGTGGTCAGAGAACATATTTTGTGTGATTTCAATCC TTTTAAATTTATTGAGGCTTATTTTATTTTATTTTATTTTTATTTTATTTTATTTTTGAGATGGAGTCTC ACTCTGTCACCAGGCTGGAGTGCAGTGGCACGACCTAAGCTCACTGCAACTTCCGCCTCCCAGGTTCAAG CGATTCTCCTGCCTCAGCCTCCTGAATAGCTGGGACTACAGGCATGTGCCACCACCCCCAGCTAATTTTT GTATTTTTAGTAGAGACAGGATTTCACCATGTTGGCCAGGATGGTCTCGATCTCTTGACCTTGTGATCTG CCCGCCTCAGCCTCCCAAAGTGCTAGGATTACAGGTTTGAGCCACTGCGCCTGGCGAGGCTTATTTTATG TTCAGGCATATTGTCTATTGTGAGAATGTGCCATGTGTACTGGAGAAGAATGTGTATTCTACGGTTGTTG GGTAGAGTGTTCTCTAGGTGTCTGTTAGGTCTGGTTGGTTTATAGTATTGTTTAAATTAGTTTTTGAGGT TTCTAAAAATGGTATCACTGGGTGTGGTGGCTCACATCTGTAATCCCAGCACTTTGGGAGGCTAAGGCAA GAGGACATTTGAGCCCCAGGAGTTCACAACCAGCCTGGGCAACAAAGAGAGACCTTGTCTCTACGAAAAA AAAAAAAAAAAATGCAAGGTGTGGTGGCTCAAGCCTGTAGTTCCAGCTACTTGGGAGGCTGAGGTGGAAG GATCACTTGAGCCTGGGATGTCGAGATTGCAGTGAGCTGTGATCATGCCACTGCACTCCAGCCTGGATGA GAGAGTGAGACCCTGTCTCAAGAAAAAAAAAAAAAGGTACCATACTAAATGTGGCTGTCTCACTGGCTGC CTTGTTATTCTCACCCAGGGCCATTGCATTTGTTGTTCCTTCATCCTAGAACTTTCTTCCCCAAGGCAAT GCATGATTTTCTTCCTCATTTCAGTCTCTGTGCATATGTCTTATAAGGACCTTTCCTGACAGACTTCCCA ACCCCTGTGTTTTTCTTTTCATCCTTCTTTGTTTTGATTTATGCCATTTATCACTATGTGAAAAAGTACA GAGTATATTTATTAGTCTACTTCTTTGTTTCTTTTACTCTTTTGTTCATTGCTATGTCACCTAGTAGGTA CTCAAAACGTATCAAGCTTCCAAATGTGAATTTGGAAGTTCTGAAGTCAGAGCAGAGGACTTGACTAAAG ATAGAAATTTGGAAATCATTAGCTTAGAGTGAAAATTTAAATTCACAGGTAGAAGAAATTACCTATGGCT AGAGGGAGGAGATAAAAGAGAAAAGGGCCAGGGCCTGGCCCTGATGAATCCAGCATCTATTAGAGGTTTG ATAGGTAAGGAGGCCTAACAAAGAAAATTGAGAAGGAGCAGAGGAGAGGGCACAGAGGTAGAAGCATCAT AGTTCTTCTAGTGTAGGGGCTGCCTGTACTAGAAATAAAGAACTAGGCCGGGCACAGTGGCTCATGCCTA TAATCCTAGCACTTTGGGAGGCCGAGGTGGGCCGATCACTTGAGGTCAGGAGTTCGAGACCAGTGTGGCC AACACAGTTGAACCCTGTCTCTACTAAAAATACAAAATTAAAAAATAATAATAATGGCCAGGCGCGGTGG CTCACGCCTGTAATCCCAGCACTTTGGCAGGCCGAGGCAGGCGAATCACGAGGTCGGGAGATCAAGACCA TCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAATTAGCCTGGCGTGGTGGCGGAT GCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGAAGAATGGCGTGAACCCGCGAGGCAGAGCTTGCAG TGAGCCGAGATCGTGCCACTGCACTCCACCCTGTGTGACAGAGCGAGACTGTGTCTAAAAAAAAAAAAAA AAAAAAAAAGTGGCCGGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAG ATCACGAGGTCAGGAGTTTGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAATACAAA AAATTAGCTGTGTGCGGTGGCGGGCGCCTGTAGTCCCAGCTACTCTGGGGGCCGAGGCAGGAGAATGGCG TGAACCTGGGAGGCGGAGCTTGCAGGGAGCCGAGATCGCGCCACTGCATTCCGGCCTGGGTGAAAGAGCG AGACTCTGTCTCAAAAAAAAAAAAAAATAATTAATAATAATAAAATAAAAATACAAAATTAGCCAGGCAT GATGGCGCATGTTTGTGATCCCAGCTACTCAGGAGGCTGAGACAGGAGAATCATTTGAACCTAGCAGGCA GAGGTTGCAGTGAGCTGAGATCACGCCATTTCGCTCTAAACTGGGCAACACAGCTAGACTCTGTCTCAAA AAAATAAAATACAAATACAAAAATTAGCCAGGGGTGGTGGTGCACGCCTGTAATCCCAACTACTTGAGAG GCTGAGGCAGGGGAATCGCTTGAACTCAGGAGGTAGAGGTTGCAGTGAGCTGAGATCGTGCCACTGCACT CCAGCCTGGGTTCCAGAGGGAGACTCCATCTCAAAAATAAATAAATAAATAAATAAAAATAACTAAAAGA GTAGGAGGTGCCATTAAAGCCATCAAAAATGGAGTAGCTAACTTAACGGAAGCCGACATGAGGTTCAGAA AGATAATGTGGCTAGAGAAGTGACTGTCAGATGCTGCAACATGAAGGCTGTTGATAGCCTTGACAAGAGC AGAAGAGTGGTGCAGACAGAAGCCGGGCTGGCTTATGTGTACTCAAGAGTGTGTAGGCCAGTTTATAAAA TAATAATTATTCAATTCAGTTTATAAAATAATAATTATTTAATTAAGCCTTTTAATAGAATCTGCAGGTT GAATCTAGTAAGTTTTCCTCCCTTCTTTTTGGCTTTCTCAGTGTTTAAAAACTCCCATATTTGGAAACTC TCTGGTGATTCCTTAAAGATTGAAAATGGGTAGATGTTGAATGCTATCTAAGCCAGATGATCCTGGGATC TTCCCACACCAGCTTCTGGGAACTGGGAAACTTCTAACTAGCTAGACAGAACTAAAGTACCATCTTCATT ATCTCTCCATGGCCTAGCACTTATATCCTTTGCAATCAGTTGACATTTATTTTCATGTAAGTGTATAGGA AAGAAGTAGCTTGCTCTTTCCTTTTTTTTTTTTTTCTTAAGAGAAGACAGGATCTTGCACTATCACCCAG GCTGGAATGCAGTGGCATGATCACAGCTCACTGCAGCCTCAACATCCTGGGCTCAATCGATCCTTCCACT TCAGCCTCCCAAGTAGCTGGGACTACAGGTGCACGCTACCATATCTGGCTAATTATTGTATTTTTTGTAG AGACAAGGTTTCACCATGTTGCCCAAGCTGGTTTTGAACTACTGGACTCAAGCGATTTGGACTCACCTTG GCCTCTCAAAGTGTTGGGATTACAGGTGTGAGCTACCATGCCTGGCCGCTGAAGTAGCTGTTTCTGTTTG CGAAAGTAGTTTTCTGCTATCATTTATTTTTGACATCTTGTCCTTGGACTATATGCAGATGTTAATCACC TTAATTATCACTATATTAGCTACCAGAAACCTAAAACATTGAAACAAGGGAATAGAGATTTGAGAAATAG ACCTATGCATATATGTAACTGGTAATTCAGCCAAGATACAAAATAATCAAATGGAGAAAGTACAGTCTTT TTAACAAATTGTGCTGGAGCAATTGGAAATCCATACGTTAAAAGATAAAAGTACTTTAACCCATACCGTA CATCATATATTAAAATTAACACAAAATGGATCATAGCTCCAAATCTAAAACCTTAAACCATAAAGCATCT GAAGAAAGGCCTGGCACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCTGGTGGATCA CCTGAGGTCAGGAGTTCGAGATCAGCCTGACCAACATGGTGAAACCCCATCTCTACTAAAAATAGGAAAA TTAGCTGAGCGGGGCCAGGCGCGGTGGCTCATGCCTGTAATCCCAGCACTTTGGAGGGCCGAGGCGGGCA GATCATGAGGTCAGAAGATCGAGACCATCCTGGCTAAGATGGTGAAACCCCATCTCTACTAAAAATACAA AAAATTAGCTGGGCATGGTGGCGGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGGAGGAGAATGGC ATGAACCCGGGAGGCAGAGCTTGCAGTGCGCTGAGGTCGCGCCACTGCACTCCAGCCTGGGTGACAGAGC AAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAATTAGCTGAGTGGTTGGGCACGGTGGCTCACACTT GTAATCCCAGAACTTTGGGAGGCTGAGGTGGATGGATCACGAGGTCAGGAGTTCGACACCAGCCTGACCA ACACGGTGAAACCCCGTCTCTACTAAAAATACAAAAGTTAGCTGGGCATGGTGGCAGGCACCTGTAATCC CAGCTACTCGGGAGGCCGAGGCAGGAGAATTGCTGAAACCTGGGAGGTAGAGGTTGCAATGAGCCGAGAT CGTGCCACTGCACTCTAGCCTGGGTGACAGAGCTAGACTCCATCTCAAAAAAAAAAAAAAAATTAGCCAA GCATGGTAGTCAGCACCTGTAATGCCAGCTACTCCAGAGGCTGAGGCAAGGAGAATCACTTGAACCTGGG AGGCGGAGGTTGCAATGAGCCGAGATCATGCCATTGCACCCCAGCCTGGGCGACAGAGTGAGACTCTGTC TCAAAAAAAAAAAAAAAAAAATCCAAAGAAAACGGAGACAATTTTTGTGACCTTGAGTTGGCAAAAATTT ATTAGATACAATGCTTAAAAATGGATACAGACTGGGCGTGGTGGCTCATGCCTGTAAACCCAGCACTTTG GTAGGCCAAGGCGGATGGATCACTTAAGCCCGGGAGTTCGAGACCAGCCTGGACAACATGGTAAAACCCT CTCTCTATAAAAAATACAGAAATTGGCTGGGCATGGTGATGCGCATCTGTAGTCCCAGTTACTCAGGAGG CTGAGTTGGGAGGATCGCTTGAGCCTGAGAGGCAGAGGTTGCAGTGAGCTAAGATTGTGCCACTGCACTC CAACCAGAGTGACAGCGAGACCCTATCTCAAAAAAAAAAAAAAAAAGATAAGTTTCAATTAGCTAATTAA TTCCAAACTCTTAGTAATATGGCTCTTAGCATAATTATTATGGTGTGTTCTAGAGAAGCCCCTTTTGAAA TCCTCATCTAGCTTTCCCCTGCCTTCTCAGGGGAAAATTGAAGTTATATGAAGTCCTGTCTGTCATGGAG ACCAGGCACCCTACTCCTCAGTGCCTCACCATATCTCCTTTCCTACCCTACCTTTGGTTGATCCATTCAT GCATCACTGGCTTCGTGGCCTTGACTGTATCTCTTGGCTTCTTCCTTTTGGGCTTTGGCTTCTGCTACTG CCTAATTATTTCTCCATCTTCCAAGTTAGGCAACCAAGAGAGGGAACCTGATTGGCCTAGATTATTTTTG CTTATTCTAGACCACTAAATAGATGTGTTCAACCAGCAATATGGTCCAGTCATCAGTGTCTGGGGGGTAG GGTGGATGGGGACATAGGGCGATGTTTGGAAGGAGTCTAAGGGTACGTATAATGTGGACGGTACCATCAG CTGGTATCACGAACAAGAGGTAGGACCATGTGTGTGATAAACAACATAATATCCATAGCTGTCATAAAGC AAAATGTTGTTATTCTTATTTCGTTCTTCCAGAAACCATTGATCATCAAGCTGCCTTCCAGTTATGGCTC TCTTATTGTATAGCCCCCCTCCTAAATCAGTCCATAACAGGTAGTGCGATAAGTGTTTAGAGAAGGAGCT TTTGCCTGTTCTCTAGGTGAGAGGTAGAGATCTCAAAGTATGTGGCAACAGAGGATAGAATTGTGGATTA GTTGGAAGGTGTTATCAGAGGTCATTTGATAGACCCTCAACTCTGAATATAGCACCCAAACCATGCCTTT CAAATAAACAACAGTCTATCCTCTTATACTTTAATCTGTTCCTGTGTAAGCAATTCTCAAGGCTAGTTCT TCATGACGTTTGAGCCACTTTTTTTTCCCTGATGGGTTTCATAGTATCCATCCTATAATGGTCAGCATGC TATTTGATTTTAGTGTGTCCTTTTTTCTTGCATGATGCTTCTTTTGCTATTTTTCTTCTTGGCTTTTCAT CTTTAGGTTTGTTGAGGTCCTTAAATCCTGATTGTCAATGTCCTAGGATCCCAGAGACAAAATGGACTTA TGTTTTTTTTTTTTTTTTTTTTTTTGGTCACATAACTGGAGGGACTGAGCTTGTGTTTGCTTTCTGTTAG AAGAACTGGTGCATCTAAGACAGTCAGCTGCAGAATTTGGTTTGGCTAGTTAAGACGTCCATGGAGATGG AATATCATGCAGTCCAGGTAGAAAGATATTAACGGGCCTATGAAGACAGGTTGCCTACCCAAGGCTTCTC AAACTTGAGAAATCACCTGGGCATCTTGTTAAAATGCAGATTTTAATTCAGTAGGTTTGGGGTGTGGCCT AACATCTGGAAACCTGCATTTCAAAGAAGCTCCCAGGAGATGTTGTTGCTGCAGGTCTGCAGACACACTT GGAGGAGTAAGAACTAGGGGGTTTAATATTCCCAAACAGGTGAGCAGAAGTGGCCTATATCGCTCCCCGT CGATGCCAGAGAACTTGAACAGGCCAAGACTGAAGCAGGTGGAAAAATTCAAGGACAACACAATACCAGA TAAAGTTAAAAAAAAGTATTTTTCTGGCCAAGGAAAGCTCAGGAAGGTAAGAACTTTTTAAGATGAAAAT CTTGTTCATCTTCTATCTCATGTCTTTGCTTTTCTGGTATGAGGATTGTTTTATTATGCCTTTTTTGTCT TCTTCCTCTTTACTTTTACTTTTTCCTCTTTGTTCTTTCCATCTTTCTGTCTTTTCTACATCTGTATCCA CGTGAAATATATATATATATATAAAATATTTATATAACATAGATACATAAAGTATATCTATATTGTACTT TTAGAAATGTTGTCATAGGCCGGGTGCAGTGGCTCACGCCTATAATCCTAGCACTTTGGGAGGCCGAGGC GGGCGGATTGCCTGAGCTCAGGAGTTCAAGACCAGACTGGGCAACACGGTGAAACCCCGTCTCTACTAAA ATACAAGAAATCAGCTGGGCGTGGCAGCATGTGCCTGTAGTCCCGGCTACTCAGGAGGCTGAGGCAGGAG AATCGCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCAA CAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAGAGAAATGTTGTCATCATACCGTCTTCCCAACCC TTTTTCTTAAGATCTGAAAGAATACAAGGGAACTTTGGTATGGATATTTTACTGCTGTTTTACATGCAGT CTGACAGAAACAACATCATATAGCAGGTTGGTTTTGTGGAAAGCAACTTCTGAAAAACTTAGCCTTTGTC CTTTACCCTCCCCAACTTTAAAAAAATTAAATAGATGGGAGGATCACTTAAGGTCAGAAGTTCAAGACCA GCCTGGTCAATATAGCATGACCCCATCTCTAATAAAAAAAAATAAAATAAAAAATTAAAATTCTAAAATC TTTGGATATTTTATAAAATCAACTTATTTATTTATTTATTTATTTTCCCCTGAGATGGGGTCTCACTCTG TCACCCAGGCTGGATTGCAGTGGCATGGTCTTGACTCACTGCAGCCTCAATATTTATTTATTATTAAAAA TAATAAATAAACAAATGGAGTCTCACTCTGTCTCCCAGACTGGAGTGCAGTGGTGCAATCGTAGCTCACT ATAGCCTTGGCCTCCTGGGCTCAAGTGATCTCCCTACCTCAGCCTCCCATGTAGCTAGGATTACAGATGT GCGCCACCATGGCCCACTCCATCCACTGGTTTTTAAACCTTTAACATGAGGATTGGGTGTGGGGTGGGAA TCTTGTCATCTTCAGGGCTTATGTTTAAAGAAGACAGTCTCTCTGTGTGACATTACTATCACTCAGATGC TGGAGGAAGATTCTAACCAGGGGCACCTGATTGGTGATTTTTCCAAGGTGAGTTTGGCTACACCCATCCT GTATTTCAGTGAGTCATTTTGGATCTGAATCTTCTCTGTTTGCCGAGAATGCCTGGTGTAAATATGCATC CTCACCAAGTACTCTTTGGTAACCTGACAGTGCTCTAGTGGTAGATCCAGGCCCTAAGCCTTTCCAGAGA GAAAGTATTTCTTATTCTTCTGGGAAGATCCAGAACAGGGGAAAGTATGAGACTTTTTACCTTTTTTCTG TTTAAAAACATATTTTAAAATTATGTAAATAATACTTGGTTGTTACAGAAAAAGTAGAAAATGAAGAAAT TTATCCCAAACTTTATTAACCAGGGTAATATTGCTTAGTATATACTCTTTTTTTCCCCCCTACTGTCTGT GTAATTGCAGAAGGTACATATTCTTACAGATTTTTTTCTGTGTTTTCACAAACACATATACAAATACAGT TTTTGCTTTTCTACAAAAACAGTTTATATTGTTTTGTTATCTGTTGTTTTTCCTCTCATTTAATAATTAT ATCAGGGGCATCTTTTTTCATATTAATAAGCAGTTATGCTTCATTCTTTCTTTTTTTAAGATTCAAGGTC TTGATCTGTTGCCCAGGCTGGAGTACATTGGCATGATCATAGCTCACTTCAGCCTCGAGCTCCTGGCCTC AAGAAATCCTCTCTCTCCTTGGCTTCCCAAAGCACTGAGGTTACAGGCATGAGCCACCATGCCCAGCCCA TTTCATTTTAATAGCTCCATATTATTTCTTTTTTTTTTTTTTTTGGCTGCTCATAATTTCTTCATAAATC CCTTCTTGTAAGATATTTGGTTTTACAATTTTTTCTTATGAATGATACCAAGATGAATATATTTGTAGAG AAATCTAAAACTTCGTACACATCCTTGATTTGTTCTTTAGGATCAGTTCTTAGAAATGGACTTGATGTAT ATGCACTTTATAGAGACACTGATTTTTTTGAAGGCCTCTGGGGTTTTAAGGGTCACTTGGAAAGAAGGAC AAAATAAGGGTCTTTGATCTCAAACTTGGGTGTGGAATACTTGCTGTTATTTCAGCTCTTGTGTATTTCT AGGTATGTGCGCTGCCAACCGTGTCAGGGAAACACCAAGATCTGAAGTATGTCAACCCAGAAACAGTAAG CAGATTTCTGGAGATGGTAACTGGTTACATAAGCTACCATCTGGTCTCTTCTGTCCCTAAAATGCCCATT TCCATTTGTATTTCTTTCACTGTGTTCACTCACACAGGCTCCTTATTCAACTGAAGTTATATTGAAGGAC TCATTTTTTTCCCCATTCTTCTCTCTCCTTCGTTTTTAGTTAAACAAATGATACATAGTTTTTGTAAAAG GGAAAAAGGGAGGGGTCAGGCATGGTGGCTCACGCCTGAAATCCTAGCATTTTGGGAGGCTGAGGCAGGC AGATCTCAGGCACTTGAGGCAGGGAATTCGAGACCACCCTGGCCAACATGGCGAAACCCCATCTCTAATA AAAATACAAAAAAATTAACCAGGCGTGGTAATGTGTGCCTATAATCCCAGCTACTTGGGAGGCTGAAGCA CAAGAATTGCTTGAACCCCAGTTGGGGAGGTTGCAGTGAGCAGAGATCGTGCCACTGTACTCCAGCCTGG GCGACACAGCGAGACTGTCTCAAAAAATAATAATTACTTAAGAAAAAAGGGAGAAAGAAAGGAAAATAAA AAATCACACACAAGAAATGGTCTCAATTAAGGTCTCAATTAGGGTGACCATGCACCCTCGTTTACATTTT ACAATCCCATTTTCATCTATTAGTGAGGGTAATTATTAATAGTGTTTGCTTTCATTCTCAAAAGTCTCCC AGTTTGTACAAAAATTATTTGGTCACCATACCCACAATCTCATCACCAGAGATAACCACTAGTCATATTT TCCTATGGCCTTCCAGATTTTATTTTATTTTTAGACATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTG CAATGGCACAATCTCGGCTTGCTGCAACCTCTGCCTCCCGGAGGTCATTCTCCTGCCTCAGCCTCCCAAG TAGCTGGGATTACAGGTGCCAGCCATCACACCGACTAATTTTTGTATTTTTAGTAGAGACGGGGTTTTAC TATGTTGGTCAGGCTGGTTTCAAACTCCTGTCCTCTGGTGATCCACCCTCCTCAGCCTCCCAAAGTGCTG GGATTACAGGTGTGAGCCACTGCGCCCAGCCCCAGATTTTATTCTAGCATATGTTTTATAGAAATGGGAT CATGGGCCTAGCACAGCTCACACCTGTAATCCCAGCACTTTGAGAGGCCAAGGCAGGCGAATCACCTGAG GTTGGGAGTTCGAGACGAGTCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATATAAAATTAGCTG GGTGTGGTAGCGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCGGG AGGCAGAGGTTGCGGTGAGCCAAGATGGCACCATTGTACTCCAGCCTGGGCAACAAGGGCGAAATTCCAT CTCAAAAAACAAAAAAAAAGGATCATGATGAACGTATAGTATTGCAATTTGCTTAGTGAGACATTATAGA CATCTTTCTATATCAATAAGGTATCTATATTATCATTTTAATGGCTATATAATGCCGCTCTATTCTACTG ACATGTACAATTTATTTTACCAAACCCCTATTATTGAATATTGAAGTTATTTCTAATATATTGATAATAT AAAACAATGCTGAGATGAATATAATTGTGCCTACATCTTTGTGTACTTTTCCTGTTTACTTAAGATGTTA GAAATTGCTGAGTCAAAGTGTGATTACATTTATTTGTATATGTATTTACAAAGTTCCCTTCAGAAAGGCT GAACCAATTTGCACTCCTACAAGTAGCTTCAGTTTCTTCCTTCCTTTAGGTATCAACCTTTCCCTTCCAT ATCCTTTCCTGAAAGACTTACTTTCTTCCTTTTTGATGGTGGGTAGGGAACCATTTTGCATTTCTTCCTG CAATTTCAAGCTCTCTAGCTGCTGCCTCTGCCACTGCAGAAGTCCTTGGGCATCTCCTGAGTCCAGCCAT GCCTATCCCCAGATGGGTAGCCTGAATATGGTTTTCCTTGGTATCTTGTCAGTGCCAGCTATTTTGGTTC TCTAAAAGGGCCACTTCCTGTTTCATTCTCTTTTGTGGAGTGGGGCTGAATCATTGCCACATATCAAATA TGGGGTGACTTTGGAGGCTGGACATACAGTGGACAGAACAGGAGTATGCTTGTAAGGAACTGTGTCATTG ACCCTTCTCTCCCTCAGAGTGGCAGTGAGCAGAATATTCAGTCATTGTTTCTGTCCAGGTGGCTGCCTTA CTGTCGGGGAAGTTCCAGGGTCTGATTGAGAAGTTTTATGTCATTGATTGTCGCTATCCATATGAGTATC TGGGAGGACACATCCAGGTGAGACGACATTGTGGCCATTAGTAGGGGAGGGCTGGAGATAACTCTTTATT GAGAAGAGTCTGTGGACAAAGGGGTCTATGAACTCTAGAGTCAGGACAAAGATTACATATTTGAAGCACC TCAAGGCTGAGGTCCTCATTGTTTTAATTCTGTATACCTTAAGCAGGTTACTTTCCCTTTCCCTCCTAGA TCTATCTCCCTCTTTTCTGTAGGAGCCAAGGGGTCCTACCTAGAAATAAAAACATTAATCCAAGGACTGA AGCACTTTGCAAACACTTACTATTCATGAACATTCCTCGCAGTGATCTCTATACTTCCAGTGGTTCAGGT CTATAAACATTTATTGACCATCTACAAGCTCTATGCCAGGCGTTCAGGGTATATACAGAGATATACTTAG ACCCCTGCCCTAAAGGTGCTTATAGTCCAGCTTTTCTGGTCCACATTATCCCAGGTTGGCGTCTCAGTCA TTTCTAAGTATTGGCACTGTCTATAAGCCCCTGAGGAAATACTTACTAAAATTCTTCTTCTACAGGGAGC CTTAAACTTATATAGTCAGGAAGAACTGTTTAACTTCTTTCTGAAGAAGCCCATCGTCCCTTTGGACACC CAGAAGAGAATAATCATCGTGTTCCACTGTGAATTCTCCTCAGAGAGGGGCCCCCGAATGTGAGTGTCTA AATGGGGTCTGGCGGGTGATGGAAATGGATTTTGAGTTGGACTTCCCACACCAGTTCAGACAGAGACTGA CTGGATTCTACAGTTTGAAGAATGTTAGGGAGGTTGAAGGAAGACGTTTCTAAAATTGAAAAGTTTGAAA CAATAAAGGAAAAGGGATTGAGAATGAGGCTGCAGTGGAGGAAAGGAGGAAGGGTGGTACTACTTGGACC TTTTTTTGCAAACACAGGGAGATTGGAAAGTCCTTTTTGAGGTTGGCAATAGTCTACTCCTCTCCCCCCT CCCCAGTGAATGGCCCCTGGGATCCTGACCTTGTTTCTTTCCACCCCACCCATCTCTGGGTTCTCTCTAA AGGTGCCGCTGTCTGCGTGAAGAGGACAGGTCTCTGAACCAGTATCCTGCATTGTACTACCCAGAGCTAT ATATCCTTAAAGGCGGCTACAGAGACTTCTTTCCAGAATATATGGTAAAGGGTGGGGCATGCGGGGAGCC AAACTTTAACAACTCAACTCCCAGGGCCTGCAAAGCCTTCAGAGAAGAAACTGCTGCTCCTCCTTAGCCA CTGCCAGCAGCAGCATCTCTATTATCCTTCATAGGTAGAGTTCAGGAGTCTAGAGAATCCCTTACTCTGT TCCTTACCTTTCAGGAACTGTGTGAACCACAGAGCTACTGCCCTATGCATCATCAGGACCACAAGACTGA GTTGCTGAGGTGTCGAAGCCAGAGCAAAGTGCAGGAAGGGGAGCGGCAGCTGCGGGAGCAGATTGCCCTT CTGGTGAAGGACATGAGCCCATGATAACATTCCAGCCACTGGCTGCTAACAAGTCACCAAAAGACACTGC AGAAACCCTGAGCAGAAAGAGGCCTTCTGGATGGCCAAACCCAAGATTATTAAAAGATGTCTCTGCAAAC CAACAGGCTACCAACTTGTATCCAGGCCTGGGAATGGATTAGGTTTCAGCAGAGCTGAAAGCTGGTGGCA GAGTCCTGGAGCTGGCTCTATAAGGCAGCCTTGAGTTGCATAGAGATTTGTATTGGTTCAGGGAACTCTG GCATTCCTTTTCCCAACTCCTCATGTCTTCTCACAAGCCAGCCAACTCTTTCTCTCTGGGCTTCGGGCTA TGCAAGAGCGTTGTCTACCTTCTTTCTTTGTATTTTCCTTCTTTGTTTCCCCCTCTTTCTTTTTTAAAAA TGGAAAAATAAACACTACAGAATGAGAGGTG Download Select all
Length	53091
OMIM ID	157680
HGNC ID	HGNC:1727
Unigene ID	Hs.656
Ensembl ID	ENSG00000158402
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001287583.1
Exon	join(1..400,7142..7369,8709..8803,9827..9872,12302..12335, 12452..12541,18982..19137,46240..46386,47616..47717, 48793..48855,51089..51187,51726..51859,52223..52334, 52515..53091)
mRNA Sequence	>995 GGTCAACGCCTGCGGCTGTTGATATTCTTGCTCAGAGGCCGTAACTTTGGCCTTCTGCTCAGGG AAGACTCTGAGTCCGACGTTGGCCTACCCAGTCGGAAGGCAGAGCTGCAATCTAGTTAACTACC TCCTTTCCCCTAGATTTCCTTTCATTCTGCTCAAGTCTTCGCCTGTGTCCGATCCCTATCTACT TTCTCTCCTCTTGTAGGCAAGCCTCAGACTCCAGGCTTGAGCTAGGTTTTGTTTTTCTCCTGGT GAGAATTCGAAGACCATGTCTACGGAACTCTTCTCATCCACAAGAGAGGAAGGAAGCTCTGGCT CAGGACCCAGTTTTAGGTCTAATCAAAGGAAAATGTTAAACCTGCTCCTGGAGAGAGACACTTC CTTTACCGTCTGTCCAGATGTCCCTAGAACTCCAGTGGGCAAATTTCTTGGTGATTCTGCAAAC CTAAGCATTTTGTCTGGGTCACCTGGATTCTTCAGGACTTCAGGAAGTGCATTTAGCTGGGATG ACAATGGAAACTTGGTGGACAGTGAAATGAAATATTTGGGCAGTCCCATTACTACTGTTCCAAA ATTGGATAAAAATCCAAACCTAGGAGAAGACCAGGCAGAAGAGATTTCAGATGAATTAATGGAG TTTTCCCTGAAAGATCAAGAAGCAAAGGTGAGCAGAAGTGGCCTATATCGCTCCCCGTCGATGC CAGAGAACTTGAACAGGCCAAGACTGAAGCAGGTGGAAAAATTCAAGGACAACACAATACCAGA TAAAGTTAAAAAAAAGTATTTTTCTGGCCAAGGAAAGCTCAGGAAGGGCTTATGTTTAAAGAAG ACAGTCTCTCTGTGTGACATTACTATCACTCAGATGCTGGAGGAAGATTCTAACCAGGGGCACC TGATTGGTGATTTTTCCAAGGTATGTGCGCTGCCAACCGTGTCAGGGAAACACCAAGATCTGAA GTATGTCAACCCAGAAACAGTGGCTGCCTTACTGTCGGGGAAGTTCCAGGGTCTGATTGAGAAG TTTTATGTCATTGATTGTCGCTATCCATATGAGTATCTGGGAGGACACATCCAGGGAGCCTTAA ACTTATATAGTCAGGAAGAACTGTTTAACTTCTTTCTGAAGAAGCCCATCGTCCCTTTGGACAC CCAGAAGAGAATAATCATCGTGTTCCACTGTGAATTCTCCTCAGAGAGGGGCCCCCGAATGTGC CGCTGTCTGCGTGAAGAGGACAGGTCTCTGAACCAGTATCCTGCATTGTACTACCCAGAGCTAT ATATCCTTAAAGGCGGCTACAGAGACTTCTTTCCAGAATATATGGAACTGTGTGAACCACAGAG CTACTGCCCTATGCATCATCAGGACCACAAGACTGAGTTGCTGAGGTGTCGAAGCCAGAGCAAA GTGCAGGAAGGGGAGCGGCAGCTGCGGGAGCAGATTGCCCTTCTGGTGAAGGACATGAGCCCAT GATAACATTCCAGCCACTGGCTGCTAACAAGTCACCAAAAGACACTGCAGAAACCCTGAGCAGA AAGAGGCCTTCTGGATGGCCAAACCCAAGATTATTAAAAGATGTCTCTGCAAACCAACAGGCTA CCAACTTGTATCCAGGCCTGGGAATGGATTAGGTTTCAGCAGAGCTGAAAGCTGGTGGCAGAGT CCTGGAGCTGGCTCTATAAGGCAGCCTTGAGTTGCATAGAGATTTGTATTGGTTCAGGGAACTC TGGCATTCCTTTTCCCAACTCCTCATGTCTTCTCACAAGCCAGCCAACTCTTTCTCTCTGGGCT TCGGGCTATGCAAGAGCGTTGTCTACCTTCTTTCTTTGTATTTTCCTTCTTTGTTTCCCCCTCT TTCTTTTTTAAAAATGGAAAAATAAACACTACAGAATGAG Download Select all
Length	1896

CDS Information

Location	join(201..400,8709..8803,9827..9872,12302..12335, 12452..12541,18982..19137,46240..46386,47616..47717, 48793..48855,51089..51187,51726..51859,52223..52334, 52515..52664)
CDS Sequence	>gi\|125625348:272-1474 Homo sapiens cell division cycle 25C (CDC25C), transcript variant 2, mRNA ATGTCTACGGAACTCTTCTCATCCACAAGAGAGGAAGGAAGCTCTGGCTCAGGACCCAGTTTTAGGTCTA ATCAAAGGAAAATGTTAAACCTGCTCCTGGAGAGAGACACTTCCTTTACCGTCTGTCCAGATGTCCCTAG AACTCCAGTGGGCAAATTTCTTGGTGATTCTGCAAACCTAAGCATTTTGTCTGGGTCACCTGGATTCTTC AGGACTTCAGGAAGTGCATTTAGCTGGGATGACAATGGAAACTTGGTGGACAGTGAAATGAAATATTTGG GCAGTCCCATTACTACTGTTCCAAAATTGGATAAAAATCCAAACCTAGGAGAAGACCAGGCAGAAGAGAT TTCAGATGAATTAATGGAGTTTTCCCTGAAAGATCAAGAAGCAAAGGTGAGCAGAAGTGGCCTATATCGC TCCCCGTCGATGCCAGAGAACTTGAACAGGCCAAGACTGAAGCAGGTGGAAAAATTCAAGGACAACACAA TACCAGATAAAGTTAAAAAAAAGTATTTTTCTGGCCAAGGAAAGCTCAGGAAGGGCTTATGTTTAAAGAA GACAGTCTCTCTGTGTGACATTACTATCACTCAGATGCTGGAGGAAGATTCTAACCAGGGGCACCTGATT GGTGATTTTTCCAAGGTATGTGCGCTGCCAACCGTGTCAGGGAAACACCAAGATCTGAAGTATGTCAACC CAGAAACAGTGGCTGCCTTACTGTCGGGGAAGTTCCAGGGTCTGATTGAGAAGTTTTATGTCATTGATTG TCGCTATCCATATGAGTATCTGGGAGGACACATCCAGGGAGCCTTAAACTTATATAGTCAGGAAGAACTG TTTAACTTCTTTCTGAAGAAGCCCATCGTCCCTTTGGACACCCAGAAGAGAATAATCATCGTGTTCCACT GTGAATTCTCCTCAGAGAGGGGCCCCCGAATGTGCCGCTGTCTGCGTGAAGAGGACAGGTCTCTGAACCA GTATCCTGCATTGTACTACCCAGAGCTATATATCCTTAAAGGCGGCTACAGAGACTTCTTTCCAGAATAT ATGGAACTGTGTGAACCACAGAGCTACTGCCCTATGCATCATCAGGACCACAAGACTGAGTTGCTGAGGT GTCGAAGCCAGAGCAAAGTGCAGGAAGGGGAGCGGCAGCTGCGGGAGCAGATTGCCCTTCTGGTGAAGGA CATGAGCCCATGA Download Select all
CCDS ID	-

Protein Information

Protein ID	NP_001274511.1
Protein Name	Cell division cycle 25 homolog C (S. pombe)
Molecular Wt. (Da)	53234
Protein Sequence	>995 MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANLSILS GGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMKCSPAQLLC STPNGLDRGHRKRDAMCSSSANKENDNGNLVDSEMKYLGSPITTVPKLDKNPNLGEDQAEEISD ELMEFSLKDQEAKVSRSGLYRSPSMPENLNRPRLKQVEKFKDNTIPDKVKKKYFSGQGKLRKGL CLKKTVSLCDITITQMLEEDSNQGHLIGDFSKVCALPTVSGKHQDLKYVNPETVAALLSGKFQG LIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERG PRMCRCLREEDRSLNQYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPMHHQDHKTELLRCR SQSKVQEGERQLREQIALLVKDMSP Download Select all
Length	473
Uniprot ID	O14727
Ensembl Protein ID	ENSP00000334558

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
K	Ubiquitination	151
C	Disulfide Bridge	330;377
S	Phosphorylation	122
T	Phosphorylation	130
S	Phosphorylation	168
S	Phosphorylation	214
T	Phosphorylation	48
T	Phosphorylation	67
S	Phosphorylation	216
S	Phosphorylation	198
S	Phosphorylation	216
S	Phosphorylation	216
S	Phosphorylation	216
S	Phosphorylation	216
S	Phosphorylation	216
S	Phosphorylation	216
S	Phosphorylation	216
S	Phosphorylation	17
S	Phosphorylation	17
S	Phosphorylation	38
S	Phosphorylation	38
T	Phosphorylation	48
S	Phosphorylation	57
S	Phosphorylation	64
S	Phosphorylation	61
S	Phosphorylation	148
S	Phosphorylation	95
T	Phosphorylation	37
T	Phosphorylation	37
S	Phosphorylation	14
S	Phosphorylation	14
S	Phosphorylation	15
S	Phosphorylation	15
S	Phosphorylation	472
S	Phosphorylation	399
S	Phosphorylation	61
S	Phosphorylation	143

Enzyme Information

EC	3.1.3.48
Name	protein-tyrosine-phosphatase phosphotyrosine phosphatase phosphoprotein phosphatase (phosphotyrosine) phosphotyrosine histone phosphatase protein phosphotyrosine phosphatase tyrosylprotein phosphatase phosphotyrosine protein phosphatase phosphotyrosylprotein phosphatase tyrosine O-phosphate phosphatase PPT-phosphatase PTPase [phosphotyrosine]protein phosphatase PTP-phosphatase
Class	Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases
Sysname	protein-tyrosine-phosphate phosphohydrolase
Substrate	protein tyrosine phosphate [CPD:C01167]; H2O
Product	protein tyrosine [CPD:C00585]; phosphate
Reaction (IUBMB)

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
890	CCNA2	453	NP_001228.1	in vitro	10864927
891	CCNB1	454	NP_114172.1	in vitro;in vivo	8 402 895 183 697 810 000 000
983	CDK1	302	NP_001777.1	in vitro;in vivo	1 183 649 995 854 070 000 000 000 000 000 000 000 000 000 000 000 000 000 000
3932	LCK	1080	NP_005347.3	in vivo	11389730
7533	YWHAH	215	NP_003396.1	in vitro;in vivo	927 851 210 330 186
10971	YWHAQ	886	NP_006817.1	in vitro	9543386

Pathway Information

Pathway Name	Pathway ID
Cell cycle	hsa04110
MicroRNAs in cancer	hsa05206
Oocyte meiosis	hsa04114
Progesterone-mediated oocyte maturation	hsa04914

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd01530	302-421	Cdc25
cl00125	302-421	RHOD superfamily
pfam06617	93-272	M-inducer_phosp
cl05906	93-272	M-inducer_phosp superfamily
cd01443	302-421	Cdc25_Acr2p
smart00450	323-423	RHOD
pfam00581	323-419	Rhodanese
cd01531	302-416	Acr2p
cd00158	323-417	RHOD
COG5105	207-447	MIH1

Ontology Information

HPRD ID	3755
Molecular Class	Dual specificity phosphatase
Molecular Function	Receptor signaling complex scaffold activity (GO:0030159)
Biological Process	Anti-apoptosis (GO:0006916)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO