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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17599042 | 2008 | Cell line : - Source : Department of Molecular Oncology, Genentech Inc, South San Francisco, CA, USA. Sample Type : - No. of Sample : - Stage : - | In situ hybridization,Immunohistochemistry,Immunoprecipitation and immunoblotting,Solid-phase receptor binding assay,Receptor pull-down assay | Up-regulation | - | Inactivation of FGF19 could be beneficial for the treatment of colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008] |
| Chromosome | 11 |
| Location | 11q13.1 |
| Start | 69513006 |
| End | 69519106 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6101 |
| OMIM ID | 603891 |
| HGNC ID | HGNC:3675 |
| Unigene ID | Hs.249200 |
| Ensembl ID | ENSG00000162344 |
| PharmGKB ID | PA28114 |
Protein Information
| Protein ID | NP_005108.1 |
|---|---|
| Protein Name | fibroblast growth factor 19 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 216 |
| Uniprot ID | O75807 |
| Ensembl Protein ID | ENSP00000200453 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2264 | FGFR4 | 625 | NP_002002.3 | in vivo | 10525310 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MAPK signaling pathway | hsa04010 |
| Melanoma | hsa05218 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Regulation of actin cytoskeleton | hsa04810 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00058 | 45-169 | FGF |
| cl00060 | 45-169 | FGF superfamily |
| smart00442 | 41-168 | FGF |
| pfam00167 | 43-166 | FGF |
Ontology Information
| HPRD ID | 5760 |
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.