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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| FGFBP1 | 9982 | fibroblast growth factor binding protein 1 | 4 | HBP17, FGFBP |
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16424058 | 2006 | Cell line : SW-13, ME180 Source : ATCC, Tissue sample from Johns Hopkins University and Georgetown University Sample Type : Paraffin-embedded CRC tissues and tissue microarrays No. of Sample : - Stage : - | In situ hybridization,Immunohistochemistry | Up-regulation | - | up-regulation of the secreted FGF-BP1 protein during initiation of pancreas and colon neoplasia could make this protein a possible serum marker indicating the presence of high-risk premalignant lesions. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011] |
| Chromosome | 4 |
| Location | 4p15.32 |
| Start | 15937192 |
| End | 15940363 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3172 |
| OMIM ID | 607737 |
| HGNC ID | HGNC:19695 |
| Unigene ID | Hs.1690 |
| Ensembl ID | ENSG00000137440 |
| PharmGKB ID | PA134880558 |
Protein Information
| Protein ID | NP_005121.1 |
|---|---|
| Protein Name | fibroblast growth factor binding protein 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 234 |
| Uniprot ID | Q14134 |
| Ensembl Protein ID | ENSP00000343129 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2246 | FGF1 | 567 | NP_000791.1 | in vitro | 11509569 |
| 2247 | FGF2 | 622 | NP_001997.5 | in vivo | 11509569 |
| 3339 | HSPG2 | 804 | NP_005520.4 | in vivo;yeast 2-hybrid | 11148217 |
| 56893 | UBQLN4 | 5670 | NP_064516.2 | yeast 2-hybrid | 16713569 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Ontology Information
| HPRD ID | 5746 |
|---|---|
| Molecular Class | Chaperone |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.