Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CDH1 | 999 | Cadherin 1, type 1, E-cadherin (epithelial)  | 16 | UVO; CDHE; ECAD; LCAM; Arc-1; CD324  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23029563    | 2012 | Cell line : - Source : Department of Pathology (University Hospital Dsseldorf, Dsseldorf, Germany). Sample Type : CRC tumor and Normal tissue No. of Sample : 41CRC and 10 normal colon mucosa Stage : - | real time RT-PCR, Immunohistochemistry | Down-regulation | - | SNAI1 and Twist1 are already expressed in benign precursor lesions of colorectal cancer and that SNAI1 expression was significantly correlated with lower expression of CDH1. |
| 21241068    | 2011 | Cell line : SW 620 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Novel high-throughput immunofluorescent screen, Immunofluorescent microscopy, In-Cell Western assay | Methylation | - | Silencing of the CDH1 gene promoter involved in Colorectal cancer and in other tumor also. |
| 12203775    | 2002 | Cell line : - Source : UK Sample Type : - No. of Sample : - Stage : - | methylation-specific PCR, immunohistochemistry | Methylation | - | Methylation of the CDH1 promoter is an attractive new biomarker for detecting ulcerative colitis patients with a high risk for developing colorectal cancers.Methylation of the E-cadherin (CDH1) promoter was detected in 93% of the patients with dysplastic biopsy samples, in contrast to only 6% of the patients without dysplasia (P < 0.001). |
| 24684676    | 2014 | Cell line : - Source : National Study of Colorectal Cancer Genetics (NSCCG). Sample Type : Population-based case-control studies No. of Sample : 2,619 cases and 2,699 healthy controls Stage : TNM Stage I | Meta-analysis | Methylation | - | CDH1 promoter methylation may be a useful biomarker for the early diagnosis of CRC. CDH1 promoter methylation may play an important role in colorectal carcinogenesis. Sample size: 883 colorectal cancer (CRC) patients. |
| 11896626    | 2002 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 130 Stage : - | - | Polymorhpism | - | - |
| 19569232    | 2009 | Cell line : - Source : Affiliated Drum Tower Hospital of Nanjing University Medical School, China. Sample Type : - No. of Sample : 290 CRC and 335 normal healthy controls Stage : TNM stage I-IV | Genotyping | Polymorhpism | - | The CDH1-160C>A polymorphism is a risk factor for colorectal cancer. |
| 19634113    | 2009 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | PCR-RFLP | Polymorhpism | - | The AA CDH1 and 1G/1G and 1G/2G MMP-1 genotypes might be associated with advned metastatic disese. |
| 19908344    | 2009 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | PCR-RFLP, Immunohistochemistry | Polymorhpism | - | The -347G-->GA promoter polymorphism in E-cadherin gene is associated with specific CRC features, and may be a prognostic factor rather than a susceptibility factor during the progression of CRC. |
| 21997289    | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Meta Analysis | Polymorhpism | - | CDH1 gene promoter -160 C-A and -347 G-GA variants might affect the susceptibility of CRC.
|
| 22339265    | 2012 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Meta analysis | Polymorhpism | - | The meta-analysis indicated that CDH1 -C160A genetic polymorphism could reduce the risk of CRC under AA versus CC contrast. |
| 20473926    | 2011 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | sE-cadherin as an alternative diagnostic biomarker for monitoring disease particularly in patients with carcinoembryonic antigen negative tumors. In individual patients with late-stage CRC, sE-cadherin serum levels directly reflect their disease status over time. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, Cadherins / Major cadherins |
| Description | This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]   |
| Chromosome | 16 |
| Location | 16q22.1 |
| Start | 68737292   |
| End | 68835542   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 98251   |
| OMIM ID | 192090    |
| HGNC ID | HGNC:1748    |
| Unigene ID | Hs.461086     |
| Ensembl ID | ENSG00000039068    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_004360.3 |
|---|---|
| Exon | join(1..172,1006..1120,64379..64602,71133..71276, 71402..71557,72906..73050,74393..74568,74844..74972, 76022..76204,78224..78468,81989..82134,84710..84934, 86108..86335,90883..91013,92363..92506,95999..98250)   | mRNA Sequence |    Download   Select all |
| Length | 4815   |
CDS Information
| Location | join(125..172,1006..1120,64379..64602,71133..71276, 71402..71557,72906..73050,74393..74568,74844..74972, 76022..76204,78224..78468,81989..82134,84710..84934, 86108..86335,90883..91013,92363..92506,95999..96208) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS10869.1 |    
Protein Information
| Protein ID | NP_004351.1 |
|---|---|
| Protein Name | Cadherin 1, type 1, E-cadherin (epithelial) |
| Molecular Wt. (Da) | 94885 |
| Protein Sequence |    Download   Select all |
| Length | 882   |
| Uniprot ID | P25054 |    
| Ensembl Protein ID | ENSP00000257430   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| D | Proteolytic Cleavage | 769 |
| D | Proteolytic Cleavage | 750 |
| S | Phosphorylation | 866 |
| S | Phosphorylation | 847 |
| S | Phosphorylation | 857 |
| S | Phosphorylation | 866 |
| S | Phosphorylation | 870 |
| S | Phosphorylation | 872 |
| S | Phosphorylation | 838 |
| S | Phosphorylation | 847 |
| S | Phosphorylation | 851 |
| S | Phosphorylation | 853 |
Enzyme Information
| EC | 1.1.99.18 |    
|---|---|
| Name | cellobiose dehydrogenase (acceptor) cellobiose dehydrogenase cellobiose oxidoreductase Phanerochaete chrysosporium cellobiose oxidoreductase CBOR cellobiose oxidase cellobiose:oxygen 1-oxidoreductase CDH cellobiose:(acceptor) 1-oxidoreductase |
| Class | Oxidoreductases; Acting on the CH-OH group of donors; With other acceptors |
| Sysname | cellobiose:acceptor 1-oxidoreductase   |
| Substrate | cellobiose [CPD:C00185]; acceptor   |
| Product | cellobiono-1,5-lactone [CPD:C01093]; reduced acceptor   |
| Reaction (IUBMB) | ![]() |
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1499 |    CTNNB1 |    286 |    NP_001895.1 |    in vitro;in vivo |    95   125   037   542   250   100   000   000   000   000   000   000   000   000   000   000   000   000    |
| 1500 |    CTNND1 |    3026 |    NP_001078927.1 |    in vitro;in vivo;yeast 2-hybrid |    765   139   975   422   501   000   000   000   000   000   000   000   000   000   000   000   000   000    |
| 1956 |    EGFR |    579 |    NP_005219.2 |    in vivo |    10969083    |
| 3667 |    IRS1 |    943 |    NP_005535.1 |    in vivo |    11035789    |
| 3695 |    ITGB7 |    948 |    NP_000880.1 |    in vivo |    10837471    |
| 3728 |    JUP |    1414 |    NP_002221.1 |    in vitro;in vivo |    820   706   175   422   501   000   000   000   000   000   000   000   000   000   000   000   000    |
| 5792 |    PTPRF |    1552 |    NP_002831.2 |    in vivo |    12095414    |
| 5797 |    PTPRM |    1479 |    NP_001098714.1 |    in vitro;in vivo |    9   531   566   764   271   310   000   000    |
| 6241 |    RRM2 |    1587 |    NP_001025.1 |    in vitro |    12655059    |
| 7414 |    VCL |    1900 |    NP_054706.1 |    in vitro |    9405455    |
| 7430 |    EZR |    475 |    NP_003370.2 |    in vivo |    10462524    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adherens junction |    hsa04520 |    
| Bacterial invasion of epithelial cells |    hsa05100 |    
| Bladder cancer |    hsa05219 |    
| Cell adhesion molecules (CAMs) |    hsa04514 |    
| Endometrial cancer |    hsa05213 |    
| Hippo signaling pathway |    hsa04390 |    
| Melanoma |    hsa05218 |    
| Pathogenic Escherichia coli infection |    hsa05130 |    
| Pathways in cancer |    hsa05200 |    
| Rap1 signaling pathway |    hsa04015 |    
| Thyroid cancer |    hsa05216 |    
Structure Information
| PDB ID | 1O6S |
|---|---|
| Resolution | 1.8 |
| Method | X-RAY DIFFRACTION |
| Chains | A   |
| Molecule | INTERNALIN A   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00031 | 158-258  | CA_like |
| cl15786 | 158-258  | CA_like superfamily |
| cd11304 | 492-591  | Cadherin_repeat |
| cl15786 | 492-591  | CA_like superfamily |
| cd11304 | 266-371  | Cadherin_repeat |
| cl15786 | 266-371  | CA_like superfamily |
| cd11304 | 379-482  | Cadherin_repeat |
| cl15786 | 379-482  | CA_like superfamily |
| pfam01049 | 738-879  | Cadherin_C |
| cl03079 | 738-879  | Cadherin_C superfamily |
| pfam08758 | 27-116  | Cadherin_pro |
| cl07391 | 27-116  | Cadherin_pro superfamily |
| smart01055 | 28-114  | Cadherin_pro |
| pfam00028 | 269-356  | Cadherin |
| smart00112 | 509-593  | CA |
| pfam00028 | 159-253  | Cadherin |
| smart00112 | 186-260  | CA |
| smart00112 | 285-373  | CA |
| cd11304 | 161-258  | Cadherin_repeat |
| pfam00028 | 493-581  | Cadherin |
| pfam00028 | 380-478  | Cadherin |
| pfam00028 | 598-686  | Cadherin |
| cl15786 | 598-686  | CA_like superfamily |
| smart00112 | 397-484  | CA |
Ontology Information
| HPRD ID | 1439 |    
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    

