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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CDH1 999 Cadherin 1, type 1, E-cadherin (epithelial)  16UVO; CDHE; ECAD; LCAM; Arc-1; CD324 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23029563   2012Cell line : -

Source : Department of Pathology (University Hospital Dsseldorf, Dsseldorf, Germany).

Sample Type : CRC tumor and Normal tissue

No. of Sample : 41CRC and 10 normal colon mucosa

Stage : -

real time RT-PCR, Immunohistochemistry Down-regulation-SNAI1 and Twist1 are already expressed in benign precursor lesions of colorectal cancer and that SNAI1 expression was significantly correlated with lower expression of CDH1.

21241068   2011Cell line : SW 620

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

Novel high-throughput immunofluorescent screen, Immunofluorescent microscopy, In-Cell Western assayMethylation-Silencing of the CDH1 gene promoter involved in Colorectal cancer and in other tumor also.

12203775   2002Cell line : -

Source : UK

Sample Type : -

No. of Sample : -

Stage : -

methylation-specific PCR, immunohistochemistryMethylation-Methylation of the CDH1 promoter is an attractive new biomarker for detecting ulcerative colitis patients with a high risk for developing colorectal cancers.Methylation of the E-cadherin (CDH1) promoter was detected in 93% of the patients with dysplastic biopsy samples, in contrast to only 6% of the patients without dysplasia (P < 0.001).

24684676   2014Cell line : -

Source : National Study of Colorectal Cancer Genetics (NSCCG).

Sample Type : Population-based case-control studies

No. of Sample : 2,619 cases and 2,699 healthy controls

Stage : TNM Stage I

Meta-analysisMethylation-CDH1 promoter methylation may be a useful biomarker for the early diagnosis of CRC.

CDH1 promoter methylation may play an important role in colorectal carcinogenesis.

Sample size: 883 colorectal cancer (CRC) patients.

11896626   2002Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 130

Stage : -

-Polymorhpism--

19569232   2009Cell line : -

Source : Affiliated Drum Tower Hospital of Nanjing University Medical School, China.

Sample Type : -

No. of Sample : 290 CRC and 335 normal healthy controls

Stage : TNM stage I-IV

GenotypingPolymorhpism-The CDH1-160C>A polymorphism is a risk factor for colorectal cancer.

19634113   2009Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

PCR-RFLPPolymorhpism-The AA CDH1 and 1G/1G and 1G/2G MMP-1 genotypes might be associated with advned metastatic disese.

19908344   2009Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

PCR-RFLP, ImmunohistochemistryPolymorhpism-The -347G-->GA promoter polymorphism in E-cadherin gene is associated with specific CRC features, and may be a prognostic factor rather than a susceptibility factor during the progression of CRC.

21997289   2012Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Meta AnalysisPolymorhpism-CDH1 gene promoter -160 C-A and -347 G-GA variants might affect the susceptibility of CRC.

22339265   2012Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Meta analysisPolymorhpism-The meta-analysis indicated that CDH1 -C160A genetic polymorphism could reduce the risk of CRC under AA versus CC contrast.

20473926   2011Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Up-regulation-sE-cadherin as an alternative diagnostic biomarker for monitoring disease particularly in patients with carcinoembryonic antigen negative tumors.

In individual patients with late-stage CRC, sE-cadherin serum levels directly reflect their disease status over time.


Gene Details



Chromosome: 16; NC_000016.9 (68771195..68869444)

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Gene Type protein coding
Gene Family CD molecules, Cadherins / Major cadherins
Description This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]  
Chromosome 16
Location 16q22.1
Start 68737292  
End 68835542  
Strand +  
Gene Sequence

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Length 98251  
OMIM ID 192090   
HGNC ID HGNC:1748   
Unigene ID Hs.461086    
Ensembl ID ENSG00000039068   
PharmGKB ID -   

mRNA Information


mRNA ID NM_004360.3
Exon join(1..172,1006..1120,64379..64602,71133..71276, 71402..71557,72906..73050,74393..74568,74844..74972, 76022..76204,78224..78468,81989..82134,84710..84934, 86108..86335,90883..91013,92363..92506,95999..98250)  
mRNA Sequence

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Length 4815  



CDS Information


   
Locationjoin(125..172,1006..1120,64379..64602,71133..71276, 71402..71557,72906..73050,74393..74568,74844..74972, 76022..76204,78224..78468,81989..82134,84710..84934, 86108..86335,90883..91013,92363..92506,95999..96208)
CDS Sequence

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CCDS ID CCDS10869.1



Protein Information


      
Protein IDNP_004351.1
Protein NameCadherin 1, type 1, E-cadherin (epithelial)
Molecular Wt. (Da)94885
Protein Sequence

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Length 882  
Uniprot IDP25054
Ensembl Protein ID ENSP00000257430  



Post-translational Modification Information (Source : HPRD)


Residue Type site
DProteolytic Cleavage769
DProteolytic Cleavage750
SPhosphorylation866
SPhosphorylation847
SPhosphorylation857
SPhosphorylation866
SPhosphorylation870
SPhosphorylation872
SPhosphorylation838
SPhosphorylation847
SPhosphorylation851
SPhosphorylation853

Enzyme Information


   
EC1.1.99.18
Namecellobiose dehydrogenase (acceptor)
cellobiose dehydrogenase
cellobiose oxidoreductase
Phanerochaete chrysosporium cellobiose oxidoreductase
CBOR
cellobiose oxidase
cellobiose:oxygen 1-oxidoreductase
CDH
cellobiose:(acceptor) 1-oxidoreductase
ClassOxidoreductases; Acting on the CH-OH group of donors; With other acceptors
Sysnamecellobiose:acceptor 1-oxidoreductase  
Substratecellobiose [CPD:C00185]; acceptor  
Productcellobiono-1,5-lactone [CPD:C01093]; reduced acceptor  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                     
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1499CTNNB1286NP_001895.1in vitro;in vivo95   125   037   542   250   100   000   000   000   000   000   000   000   000   000   000   000   000   
1500CTNND13026NP_001078927.1in vitro;in vivo;yeast 2-hybrid765   139   975   422   501   000   000   000   000   000   000   000   000   000   000   000   000   000   
1956EGFR579NP_005219.2in vivo10969083   
3667IRS1943NP_005535.1in vivo11035789   
3695ITGB7948NP_000880.1in vivo10837471   
3728JUP1414NP_002221.1in vitro;in vivo820   706   175   422   501   000   000   000   000   000   000   000   000   000   000   000   000   
5792PTPRF1552NP_002831.2in vivo12095414   
5797PTPRM1479NP_001098714.1in vitro;in vivo9   531   566   764   271   310   000   000   
6241RRM21587NP_001025.1in vitro12655059   
7414VCL1900NP_054706.1in vitro9405455   
7430EZR475NP_003370.2in vivo10462524   


Pathway Information


                                                                  
Pathway Name Pathway ID
Adherens junction hsa04520
Bacterial invasion of epithelial cells hsa05100
Bladder cancer hsa05219
Cell adhesion molecules (CAMs) hsa04514
Endometrial cancer hsa05213
Hippo signaling pathway hsa04390
Melanoma hsa05218
Pathogenic Escherichia coli infection hsa05130
Pathways in cancer hsa05200
Rap1 signaling pathway hsa04015
Thyroid cancer hsa05216


Structure Information


PDB ID1O6S
Resolution1.8
MethodX-RAY DIFFRACTION
Chains A  
Molecule INTERNALIN A  
Model View



Domain Information




ID Location Description
cd00031158-258  CA_like
cl15786158-258  CA_like superfamily
cd11304492-591  Cadherin_repeat
cl15786492-591  CA_like superfamily
cd11304266-371  Cadherin_repeat
cl15786266-371  CA_like superfamily
cd11304379-482  Cadherin_repeat
cl15786379-482  CA_like superfamily
pfam01049738-879  Cadherin_C
cl03079738-879  Cadherin_C superfamily
pfam0875827-116  Cadherin_pro
cl0739127-116  Cadherin_pro superfamily
smart0105528-114  Cadherin_pro
pfam00028269-356  Cadherin
smart00112509-593  CA
pfam00028159-253  Cadherin
smart00112186-260  CA
smart00112285-373  CA
cd11304161-258  Cadherin_repeat
pfam00028493-581  Cadherin
pfam00028380-478  Cadherin
pfam00028598-686  Cadherin
cl15786598-686  CA_like superfamily
smart00112397-484  CA


Ontology Information


   
HPRD ID1439
Molecular ClassAdhesion molecule
Molecular FunctionCell adhesion molecule activity (GO:0005194)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO