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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
9-Sep 10801 septin 9  17MSF1, KIAA0991, PNUTL4, AF17q25, SeptD1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
23988185   2013Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Bisulfite sequencing and immunohistochemistryHypermethylation-Hypermethylation of SEPT9 in adenoma and CRC specimens is confined to one of several CpG islands of this gene.

20140221   2010Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Heavy Methyl technique, Real Time RT-PCRMethylation-Methylated DNA from advanced precancerous colorectal lesions can be detected using a panel of two DNA methylation markers, ALX4 and SEPT9.

Methylation of SEPT9 was observed in 9% of controls (3/33), 29% of patients with colorectal precancerous lesions (27/94) and 73% of colorectal cancer patients (24/33).

Sample size: Plasma from 128 individuals (cohort I - exploratory study: 73 cases / 55 controls), 76 individuals (cohort II - validation study: 54 cases / 22 controls).

19406918   2009Cell line : -

Source : -

Sample Type : Blood sample

No. of Sample : -

Stage : -

real time RT-PCRMethylation-Circulating methylated SEPT9 DNA, as measured in the new (m)SEPT9 assay, is a valuable biomarker for minimally invasive detection of colorectal cancer.

25123042   2014Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 93

Stage : -

-Methylation-Peripheral blood SEPT9 gene methylation assay has become a potential option with promising future for early detection and screening of colorectal cancer.

23049919   2012Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 50 untreated CRC patients, 94 control samples.

Stage : -

real time RT-PCRMethylation-Septin 9 marker may be a safe and useful test for CRC screening.

The high degree of sensitivity and specificity of SEPT9 in plasma makes it a better method to detect CRC than gFOBT and CEA, even for the more difficult to detect RSCC.

22168215   2011Cell line : -

Source : Affiliated Hospital of Inner Mongolia Medical College

Sample Type : CRC tumor and normal tissue

No. of Sample : 234 colorectal tissues (172 cases, 62 controls)

Stage : -

real time RT-PCRMethylation-A sensitive blood-based CRC screening test using the SEPT9 biomarker specifically detects a majority of CRCs of all stages and colorectal locations.

The improved SEPT9 methylated DNA test was more sensitive than previously described methods; the test had an overall sensitivity for CRC of 90% (95% CI, 77.4% to 96.3%) and specificity of 88% (95% CI, 79.6% to 93.7%), detecting CRC in patients of all stages.

24535900   2014Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

ethylation-specific PCR,denaturing high-performance liquid chromatography (MSP-DHPLC)Methylation-SEPT9 gene methylation is a valuable biomarker for screening CRC in the Chinese population.

SEPT9 gene methylation was detected in 152 of 172 (88.4%) cases of verified CRC and in 4 of 62 (6.5%) healthy controls (?(2) = 137.62, P < 0.001).


Gene Details



Chromosome 17 - NC_000017.11 (77281410..77500596)

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Gene Type protein coding
Gene Family Septins
Description This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.[  
Chromosome 17
Location 17q25.3
Start 77281410  
End 77500596  
Strand +  
Gene Sequence

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Length 219187  
OMIM ID 604061   
HGNC ID HGNC:7323   
Unigene ID Hs.440932   
Ensembl ID ENSG00000184640   
PharmGKB ID -   

mRNA Information


mRNA ID XM_011525582.1
Exon complement(203..1290)  
mRNA Sequence

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Length 3837  



CDS Information


   
Location complement(203..551)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_001106963.1
Protein Nameseptin 9
Molecular Wt. (Da)65271
Protein Sequence

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Length 586  
Uniprot IDP05106
Ensembl Protein ID ENSP00000452786  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation30
SPhosphorylation12
SPhosphorylation85;-
SPhosphorylation67;-
YPhosphorylation260;-
YPhosphorylation278;-
SPhosphorylation80
SPhosphorylation62
SPhosphorylation82
SPhosphorylation64
TPhosphorylation42
TPhosphorylation24
SPhosphorylation89
SPhosphorylation71
TPhosphorylation142
TPhosphorylation124
KAcetylation352
KAcetylation334
SPhosphorylation41
SPhosphorylation23
TPhosphorylation38
TPhosphorylation20
TPhosphorylation49
TPhosphorylation31
SPhosphorylation238
SPhosphorylation220
SPhosphorylation22
SPhosphorylation96
SPhosphorylation78
SPhosphorylation203
SPhosphorylation185
TPhosphorylation235
TPhosphorylation217

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                            
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3091HIF1A4517NP_001521.1in vitro;in vivo16424018   
47352-Sep3297NP_004395.1in vivo12388755   
10890RAB106692NP_057215.3yeast 2-hybrid16169070   
231576-Sep6716NP_055944.2in vivo12388755   


Pathway Information


      
Pathway Name Pathway ID
Bacterial invasion of epithelial cells hsa05100


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd01850295-569  CDC_Septin
cl21455295-569  P-loop_NTPase superfamily
pfam00735296-565  Septin
cd00882303-474  Ras_like_GTPase
cd01853260-414  Toc34_like
cd09912299-474  DLP_2
pfam01926300-366  MMR_HSR1
cd01855280-366  YqeH
pfam04548300-365  AIG1
cd11383304-367  YfjP
cd01854280-366  YjeQ_EngC
cd00880303-368  Era_like
cd01856281-365  YlqF
pfam03193303-366  DUF258
cd01876301-454  YihA_EngB
cd04163293-474  Era
cd01859280-365  MJ1464
pfam0593482-256  MCLC
cl0547982-256  MCLC superfamily
cd04170300-368  EF-G_bact
cd01852300-368  AIG1
PRK00454304-474  engB
TIGR03598304-475  GTPase_YsxC
pfam09483142-254  HpaP
cl22974142-254  HpaP superfamily
COG5019277-583  CDC3
PHA03269150-278  PHA03269
PHA03247141-267  PHA03247
COG1100298-366  Gem1
TIGR00231298-365  small_GTP
PRK14951141-251  PRK14951
PHA0324739-247  PHA03247
TIGR03597280-380  GTPase_YqeH
COG3596284-368  YeeP
PRK12323142-275  PRK12323
PRK14959157-273  PRK14959
PRK07003118-273  PRK07003
PRK07764143-259  PRK07764
PHA032477-236  PHA03247
PLN03209103-269  PLN03209
TIGR0092710-230  2A1904
PRK12323139-284  PRK12323
TIGR03835163-265  termin_org_DnaJ
PHA03307146-274  PHA03307
COG1159293-495  Era
PRK1232340-253  PRK12323
TIGR00993297-383  3a0901s04IAP86
PRK14950167-252  PRK14950
PHA03269141-232  PHA03269
PHA03247142-268  PHA03247
PHA03378143-272  PHA03378
PRK12270165-251  kgd
PRK1232396-273  PRK12323
PRK1232370-268  PRK12323
PRK14951156-274  PRK14951
PRK00030167-246  minC
PRK07764157-259  PRK07764
PRK0700341-262  PRK07003
COG0218301-454  EngB
PRK08691144-278  PRK08691
COG1161285-365  RbgA
PHA03247143-249  PHA03247
PHA0330717-272  PHA03307
TIGR00436301-495  era
PRK07764163-273  PRK07764
PLN03118299-365  PLN03118
PRK07994142-273  PRK07994
PRK07764142-264  PRK07764
PHA03291123-245  PHA03291
PHA03307121-283  PHA03307
COG1162275-374  RsgA
PRK06995154-263  flhF
PHA03369155-254  PHA03369
PRK07764142-273  PRK07764
COG3147156-246  DedD
PHA03378140-327  PHA03378
COG1160301-456  Der
PRK00098283-373  PRK00098
PRK07764167-266  PRK07764
PRK11633156-279  PRK11633
PRK14951166-276  PRK14951
PRK07994141-275  PRK07994
PTZ00449141-236  PTZ00449
PHA0324737-263  PHA03247
COG3266167-273  DamX
PHA0324739-230  PHA03247
pfam06070100-275  Herpes_UL32
PRK10263144-246  PRK10263
PRK03427157-241  PRK03427
PHA03247147-273  PHA03247
PRK10905150-267  PRK10905
PRK07994162-278  PRK07994
PRK13796280-365  PRK13796
PRK14954138-245  PRK14954
PRK10905142-221  PRK10905
PRK03427105-240  PRK03427
PRK07764166-266  PRK07764
PRK11901176-268  PRK11901
PRK06995175-290  flhF
PRK12373100-260  PRK12373
pfam05466131-272  BASP1
COG311592-241  ZipA
PRK14948168-254  PRK14948
PRK07003139-273  PRK07003
PHA03307143-283  PHA03307
PRK12270147-236  kgd
PRK07764139-275  PRK07764
TIGR02927195-251  SucB_Actino
PHA0330723-273  PHA03307
COG317073-291  FimV
PRK12372133-273  PRK12372
PRK14718146-265  PRK14718
PRK07764142-244  PRK07764
PRK14965163-247  PRK14965


Ontology Information


   
HPRD ID949
Molecular ClassGTPase
Molecular FunctionCell adhesion molecule activity (GO:0005194)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO