Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| 9-Sep | 10801 | septin 9  | 17 | MSF1, KIAA0991, PNUTL4, AF17q25, SeptD1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23988185    | 2013 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Bisulfite sequencing and immunohistochemistry | Hypermethylation | - | Hypermethylation of SEPT9 in adenoma and CRC specimens is confined to one of several CpG islands of this gene. |
| 20140221    | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Heavy Methyl technique, Real Time RT-PCR | Methylation | - | Methylated DNA from advanced precancerous colorectal lesions can be detected using a panel of two DNA methylation markers, ALX4 and SEPT9. Methylation of SEPT9 was observed in 9% of controls (3/33), 29% of patients with colorectal precancerous lesions (27/94) and 73% of colorectal cancer patients (24/33). Sample size: Plasma from 128 individuals (cohort I - exploratory study: 73 cases / 55 controls), 76 individuals (cohort II - validation study: 54 cases / 22 controls). |
| 19406918    | 2009 | Cell line : - Source : - Sample Type : Blood sample No. of Sample : - Stage : - | real time RT-PCR | Methylation | - | Circulating methylated SEPT9 DNA, as measured in the new (m)SEPT9 assay, is a valuable biomarker for minimally invasive detection of colorectal cancer. |
| 25123042    | 2014 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 93 Stage : - | - | Methylation | - | Peripheral blood SEPT9 gene methylation assay has become a potential option with promising future for early detection and screening of colorectal cancer. |
| 23049919    | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 50 untreated CRC patients, 94 control samples. Stage : - | real time RT-PCR | Methylation | - | Septin 9 marker may be a safe and useful test for CRC screening. The high degree of sensitivity and specificity of SEPT9 in plasma makes it a better method to detect CRC than gFOBT and CEA, even for the more difficult to detect RSCC. |
| 22168215    | 2011 | Cell line : - Source : Affiliated Hospital of Inner Mongolia Medical College Sample Type : CRC tumor and normal tissue No. of Sample : 234 colorectal tissues (172 cases, 62 controls) Stage : - | real time RT-PCR | Methylation | - | A sensitive blood-based CRC screening test using the SEPT9 biomarker specifically detects a majority of CRCs of all stages and colorectal locations. The improved SEPT9 methylated DNA test was more sensitive than previously described methods; the test had an overall sensitivity for CRC of 90% (95% CI, 77.4% to 96.3%) and specificity of 88% (95% CI, 79.6% to 93.7%), detecting CRC in patients of all stages. |
| 24535900    | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | ethylation-specific PCR,denaturing high-performance liquid chromatography (MSP-DHPLC) | Methylation | - | SEPT9 gene methylation is a valuable biomarker for screening CRC in the Chinese population. SEPT9 gene methylation was detected in 152 of 172 (88.4%) cases of verified CRC and in 4 of 62 (6.5%) healthy controls (?(2) = 137.62, P < 0.001). |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Septins |
| Description | This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.[   | Chromosome | 17 |
| Location | 17q25.3 |
| Start | 77281410   |
| End | 77500596   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 219187   |
| OMIM ID | 604061    |
| HGNC ID | HGNC:7323    |
| Unigene ID | Hs.440932    |
| Ensembl ID | ENSG00000184640    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_011525582.1 |
|---|---|
| Exon | complement(203..1290)   | mRNA Sequence |    Download   Select all |
| Length | 3837   |
CDS Information
| Location | complement(203..551) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_001106963.1 |
|---|---|
| Protein Name | septin 9 |
| Molecular Wt. (Da) | 65271 |
| Protein Sequence |    Download   Select all |
| Length | 586   |
| Uniprot ID | P05106 |    
| Ensembl Protein ID | ENSP00000452786   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 30 |
| S | Phosphorylation | 12 |
| S | Phosphorylation | 85;- |
| S | Phosphorylation | 67;- |
| Y | Phosphorylation | 260;- |
| Y | Phosphorylation | 278;- |
| S | Phosphorylation | 80 |
| S | Phosphorylation | 62 |
| S | Phosphorylation | 82 |
| S | Phosphorylation | 64 |
| T | Phosphorylation | 42 |
| T | Phosphorylation | 24 |
| S | Phosphorylation | 89 |
| S | Phosphorylation | 71 |
| T | Phosphorylation | 142 |
| T | Phosphorylation | 124 |
| K | Acetylation | 352 |
| K | Acetylation | 334 |
| S | Phosphorylation | 41 |
| S | Phosphorylation | 23 |
| T | Phosphorylation | 38 |
| T | Phosphorylation | 20 |
| T | Phosphorylation | 49 |
| T | Phosphorylation | 31 |
| S | Phosphorylation | 238 |
| S | Phosphorylation | 220 |
| S | Phosphorylation | 22 |
| S | Phosphorylation | 96 |
| S | Phosphorylation | 78 |
| S | Phosphorylation | 203 |
| S | Phosphorylation | 185 |
| T | Phosphorylation | 235 |
| T | Phosphorylation | 217 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3091 |    HIF1A |    4517 |    NP_001521.1 |    in vitro;in vivo |    16424018    |
| 4735 |    2-Sep |    3297 |    NP_004395.1 |    in vivo |    12388755    |
| 10890 |    RAB10 |    6692 |    NP_057215.3 |    yeast 2-hybrid |    16169070    |
| 23157 |    6-Sep |    6716 |    NP_055944.2 |    in vivo |    12388755    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Bacterial invasion of epithelial cells |    hsa05100 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01850 | 295-569  | CDC_Septin |
| cl21455 | 295-569  | P-loop_NTPase superfamily |
| pfam00735 | 296-565  | Septin |
| cd00882 | 303-474  | Ras_like_GTPase |
| cd01853 | 260-414  | Toc34_like |
| cd09912 | 299-474  | DLP_2 |
| pfam01926 | 300-366  | MMR_HSR1 |
| cd01855 | 280-366  | YqeH |
| pfam04548 | 300-365  | AIG1 |
| cd11383 | 304-367  | YfjP |
| cd01854 | 280-366  | YjeQ_EngC |
| cd00880 | 303-368  | Era_like |
| cd01856 | 281-365  | YlqF |
| pfam03193 | 303-366  | DUF258 |
| cd01876 | 301-454  | YihA_EngB |
| cd04163 | 293-474  | Era |
| cd01859 | 280-365  | MJ1464 |
| pfam05934 | 82-256  | MCLC |
| cl05479 | 82-256  | MCLC superfamily |
| cd04170 | 300-368  | EF-G_bact |
| cd01852 | 300-368  | AIG1 |
| PRK00454 | 304-474  | engB |
| TIGR03598 | 304-475  | GTPase_YsxC |
| pfam09483 | 142-254  | HpaP |
| cl22974 | 142-254  | HpaP superfamily |
| COG5019 | 277-583  | CDC3 |
| PHA03269 | 150-278  | PHA03269 |
| PHA03247 | 141-267  | PHA03247 |
| COG1100 | 298-366  | Gem1 |
| TIGR00231 | 298-365  | small_GTP |
| PRK14951 | 141-251  | PRK14951 |
| PHA03247 | 39-247  | PHA03247 |
| TIGR03597 | 280-380  | GTPase_YqeH |
| COG3596 | 284-368  | YeeP |
| PRK12323 | 142-275  | PRK12323 |
| PRK14959 | 157-273  | PRK14959 |
| PRK07003 | 118-273  | PRK07003 |
| PRK07764 | 143-259  | PRK07764 |
| PHA03247 | 7-236  | PHA03247 |
| PLN03209 | 103-269  | PLN03209 |
| TIGR00927 | 10-230  | 2A1904 |
| PRK12323 | 139-284  | PRK12323 |
| TIGR03835 | 163-265  | termin_org_DnaJ |
| PHA03307 | 146-274  | PHA03307 |
| COG1159 | 293-495  | Era |
| PRK12323 | 40-253  | PRK12323 |
| TIGR00993 | 297-383  | 3a0901s04IAP86 |
| PRK14950 | 167-252  | PRK14950 |
| PHA03269 | 141-232  | PHA03269 |
| PHA03247 | 142-268  | PHA03247 |
| PHA03378 | 143-272  | PHA03378 |
| PRK12270 | 165-251  | kgd |
| PRK12323 | 96-273  | PRK12323 |
| PRK12323 | 70-268  | PRK12323 |
| PRK14951 | 156-274  | PRK14951 |
| PRK00030 | 167-246  | minC |
| PRK07764 | 157-259  | PRK07764 |
| PRK07003 | 41-262  | PRK07003 |
| COG0218 | 301-454  | EngB |
| PRK08691 | 144-278  | PRK08691 |
| COG1161 | 285-365  | RbgA |
| PHA03247 | 143-249  | PHA03247 |
| PHA03307 | 17-272  | PHA03307 |
| TIGR00436 | 301-495  | era |
| PRK07764 | 163-273  | PRK07764 |
| PLN03118 | 299-365  | PLN03118 |
| PRK07994 | 142-273  | PRK07994 |
| PRK07764 | 142-264  | PRK07764 |
| PHA03291 | 123-245  | PHA03291 |
| PHA03307 | 121-283  | PHA03307 |
| COG1162 | 275-374  | RsgA |
| PRK06995 | 154-263  | flhF |
| PHA03369 | 155-254  | PHA03369 |
| PRK07764 | 142-273  | PRK07764 |
| COG3147 | 156-246  | DedD |
| PHA03378 | 140-327  | PHA03378 |
| COG1160 | 301-456  | Der |
| PRK00098 | 283-373  | PRK00098 |
| PRK07764 | 167-266  | PRK07764 |
| PRK11633 | 156-279  | PRK11633 |
| PRK14951 | 166-276  | PRK14951 |
| PRK07994 | 141-275  | PRK07994 |
| PTZ00449 | 141-236  | PTZ00449 |
| PHA03247 | 37-263  | PHA03247 |
| COG3266 | 167-273  | DamX |
| PHA03247 | 39-230  | PHA03247 |
| pfam06070 | 100-275  | Herpes_UL32 |
| PRK10263 | 144-246  | PRK10263 |
| PRK03427 | 157-241  | PRK03427 |
| PHA03247 | 147-273  | PHA03247 |
| PRK10905 | 150-267  | PRK10905 |
| PRK07994 | 162-278  | PRK07994 |
| PRK13796 | 280-365  | PRK13796 |
| PRK14954 | 138-245  | PRK14954 |
| PRK10905 | 142-221  | PRK10905 |
| PRK03427 | 105-240  | PRK03427 |
| PRK07764 | 166-266  | PRK07764 |
| PRK11901 | 176-268  | PRK11901 |
| PRK06995 | 175-290  | flhF |
| PRK12373 | 100-260  | PRK12373 |
| pfam05466 | 131-272  | BASP1 |
| COG3115 | 92-241  | ZipA |
| PRK14948 | 168-254  | PRK14948 |
| PRK07003 | 139-273  | PRK07003 |
| PHA03307 | 143-283  | PHA03307 |
| PRK12270 | 147-236  | kgd |
| PRK07764 | 139-275  | PRK07764 |
| TIGR02927 | 195-251  | SucB_Actino |
| PHA03307 | 23-273  | PHA03307 |
| COG3170 | 73-291  | FimV |
| PRK12372 | 133-273  | PRK12372 |
| PRK14718 | 146-265  | PRK14718 |
| PRK07764 | 142-244  | PRK07764 |
| PRK14965 | 163-247  | PRK14965 |
Ontology Information
| HPRD ID | 949 |    
|---|---|
| Molecular Class | GTPase |
| Molecular Function | Cell adhesion molecule activity (GO:0005194) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
