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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ABI1 10006 abl-interactor 1  10E3B1, ABI-1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22808230   2012Cell line : -

Source : Institute of Pathology of the University of Ulm

Sample Type : CRC tumor and adjacent normal tissue

No. of Sample : 126

Stage : Duke Stage A-D

 Immunohistochemistry, western blotting,Immunofluorescence MicroscopyUp-regulation--

24913355   2014Cell line : -

Source : Institute of Pathology, Bundeswehrkrankenhaus Ulm.

Sample Type : CRC tumor

No. of Sample : 56

Stage : UICC Stage I-IV

Matrix degradation assays,Fibronectin cell adhesion assay, ImmunofluorescenceUp-regulation-phosphorylated Abi1 contributes to the invasive properties of colorectal cancer.


Gene Details



NC_000010.10 (27035525..27150016, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]  
Chromosome 10
Location 10p12.1
Start 27035525  
End 27150016  
Strand -  
Gene Sequence

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Length 114492  
OMIM ID 603050   
HGNC ID HGNC:11320   
Unigene ID Hs.508148   
Ensembl ID ENSG00000136754   
PharmGKB ID PA36144   

mRNA Information


mRNA ID ?NM_001012750.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS31169.1



Protein Information


      
Protein IDNP_001012768.1
Protein Nameabl-interactor 1
Molecular Wt. (Da)0
Protein Sequence

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Length 508  
Uniprot IDQ9UIK5
Ensembl Protein ID ENSP00000272771  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation183;-
SPhosphorylation183;-
SPhosphorylation183;-
SPhosphorylation178;-
YPhosphorylation208;-
YPhosphorylation213;-
YPhosphorylation213;-
YPhosphorylation213;-
SPhosphorylation225;-
SPhosphorylation225;-
SPhosphorylation225;-
SPhosphorylation220;-
TPhosphorylation215
TPhosphorylation215
TPhosphorylation215
TPhosphorylation210
SPhosphorylation216
SPhosphorylation216
SPhosphorylation216
SPhosphorylation211
SPhosphorylation222
SPhosphorylation222
SPhosphorylation222
SPhosphorylation217
TPhosphorylation178
TPhosphorylation178
TPhosphorylation178
TPhosphorylation173
SPhosphorylation323
SPhosphorylation296
SPhosphorylation296
SPhosphorylation291
YPhosphorylation198
YPhosphorylation198
YPhosphorylation198
YPhosphorylation193
TPhosphorylation200
TPhosphorylation208
TPhosphorylation200
TPhosphorylation208
TPhosphorylation200
TPhosphorylation208
TPhosphorylation195
TPhosphorylation203
YPhosphorylation212
YPhosphorylation212
YPhosphorylation212
YPhosphorylation207
TPhosphorylation507
TPhosphorylation480
TPhosphorylation451
TPhosphorylation475

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
2059EPS82563NP_004438.3in vitro;in vivo1   109   904   690   102   250   000   000   000   000   000   000   000   000   000   000   
4687NCF11990NP_000256.3in vitro;yeast 2-hybrid12681507   
4690NCK12740NP_006144.1yeast 2-hybrid11418237   
4703NEB1196NP_004534.2in vitro15048123   
6654SOS11681NP_005624.2in vitro;in vivo10499589   
6655SOS23149NP_008870.2in vivo11003655   
6708SPTA11685NP_003117.2in vitro;in vivo;yeast 2-hybrid9593709   
6709SPTAN11684NP_001123910.1in vitro;yeast 2-hybrid9593709   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd11971450-508  SH3_Abi1
cl17036450-508  SH3 superfamily
pfam0781593-171  Abi_HHR
cl0672193-171  Abi_HHR superfamily
cd11972447-507  SH3_Abi2
cd11826450-501  SH3_Abi
smart00326448-501  SH3
cd00174450-499  SH3
cd11772453-502  SH3_OSTF1
cd11877450-501  SH3_PIX
cd11819452-501  SH3_Cortactin_like
cd11840450-501  SH3_Intersectin_5
cd11780453-501  SH3_Sorbs_3
pfam00018452-496  SH3_1
pfam14604453-501  SH3_9
cd11996450-501  SH3_Intersectin2_5
cd11959452-501  SH3_Cortactin
cd11823452-501  SH3_Nostrin
cd11789450-501  SH3_Nebulin_family_C
cd11803453-503  SH3_Endophilin_A
cd11825451-501  SH3_PLCgamma
cd11762453-501  SH3_FCHSD_2
cd11961451-501  SH3_Abp1_fungi_C2
cd11827450-501  SH3_MyoIe_If_like
cd11875450-501  SH3_CD2AP-like_3
cd11766450-501  SH3_Nck_2
cd11873450-501  SH3_CD2AP-like_1
cd11995450-501  SH3_Intersectin1_5
cd11824450-501  SH3_PSTPIP1
cd12073452-501  SH3_HS1
cd11934453-503  SH3_Lasp1_C
cd11882450-501  SH3_GRAF-like
cd11793451-501  SH3_ephexin1_like
cd11778450-499  SH3_Bzz1_2
cd11964450-502  SH3_STAM1
pfam07653450-501  SH3_2
cd11781453-501  SH3_Sorbs_1
cd11963450-502  SH3_STAM2
cd11883451-499  SH3_Sdc25
cd11916453-501  SH3_Sorbs1_3
cd11783451-502  SH3_SH3RF_3
cd11820450-502  SH3_STAM
cd11843451-501  SH3_PACSIN
cd12060451-503  SH3_alphaPIX
cd11874453-501  SH3_CD2AP-like_2
cd11805450-501  SH3_GRB2_like_C
cd11786453-501  SH3_SH3RF_1
cd12142454-501  SH3_D21-like
cd11856452-501  SH3_p47phox_like
cd11887450-501  SH3_Bbc1
cd12061451-503  SH3_betaPIX
cd11785453-502  SH3_SH3RF_C
cd11949451-501  SH3_GRB2_C
cd11969451-503  SH3_PLCgamma2
cd11970451-503  SH3_PLCgamma1
cd11917449-503  SH3_Sorbs2_3
cd11918453-503  SH3_Vinexin_3
cd11933453-503  SH3_Nebulin_C
cd11894451-501  SH3_FCHSD2_2
cd11960453-501  SH3_Abp1_eu
cd11821450-499  SH3_ASAP
cd11962452-501  SH3_Abp1_fungi_C1
cd11763450-501  SH3_SNX9_like
cd11812451-500  SH3_AHI-1
cd12052455-500  SH3_CIN85_1
cd11842450-501  SH3_Ysc84p_like
cd11791453-501  SH3_UBASH3
cd11950451-501  SH3_GRAP2_C
cd11901455-500  SH3_Nck1_2
cd11815452-501  SH3_Eve1_2
cd12046450-501  SH3_p67phox_C
cd11920453-503  SH3_Sorbs2_1
cd12058453-500  SH3_MLK4
cd11935453-503  SH3_Nebulette_C
cd11790450-503  SH3_Amphiphysin
cd11951451-500  SH3_GRAP_C
cd11838452-500  SH3_Intersectin_3
cd11925452-503  SH3_SH3RF3_3
cd12055453-501  SH3_CIN85_2
cd11999450-501  SH3_PACSIN_like
cd12056453-500  SH3_CD2AP_3
cd11836453-501  SH3_Intersectin_1
cd11876452-500  SH3_MLK
cd11870450-501  SH3_p67phox-like_C
cd11902455-500  SH3_Nck2_2
cd11817451-499  SH3_Eve1_4
cd11997450-501  SH3_PACSIN3
cd11991452-500  SH3_Intersectin1_3
cd11926452-500  SH3_SH3RF1_3
cd11839448-501  SH3_Intersectin_4
cd11796462-500  SH3_DNMBP_N3
cd11851450-502  SH3_RIM-BP
cd11841451-500  SH3_SH3YL1_like
cd11804452-500  SH3_GRB2_like_N
cd11774450-500  SH3_Sla1p_2
cd11782450-501  SH3_Sorbs_2
cd12012452-501  SH3_RIM-BP_2
cd11837450-500  SH3_Intersectin_2
cd12054454-503  SH3_CD2AP_2
cd12013450-502  SH3_RIM-BP_3
cd12057454-501  SH3_CIN85_3
cd11773453-499  SH3_Sla1p_1
cd11818450-499  SH3_Eve1_5
cd12059453-502  SH3_MLK1-3
cd11946450-501  SH3_GRB2_N
cd12053450-503  SH3_CD2AP_1
cd11758449-501  SH3_CRK_N
cd11929453-501  SH3_SH3RF2_1
cd11992452-500  SH3_Intersectin2_3
cd11787453-499  SH3_SH3RF_2
cd11816452-500  SH3_Eve1_3
cd11845451-499  SH3_Src_like
cd11895451-503  SH3_FCHSD1_2
cd12047450-496  SH3_Noxa1_C
cd11830452-501  SH3_VAV_2
cd12016449-501  SH3_Tks_2
cd11955452-500  SH3_srGAP1-3
cd11924452-501  SH3_Vinexin_2
cd11767450-501  SH3_Nck_3
cd11878453-499  SH3_Bem1p_1
cd11976453-501  SH3_VAV1_2
cd11806451-500  SH3_PRMT2
cd12065450-501  SH3_GRAF2
cd11998450-502  SH3_PACSIN1-2
cd11770451-501  SH3_Nephrocystin
cd12022452-501  SH3_p47phox_2
cd11927453-501  SH3_SH3RF1_1
cd11833452-500  SH3_Stac_1
cd12076449-501  SH3_Tks4_2
cd11807451-499  SH3_ASPP
cd11965450-500  SH3_ASAP1
cd11919453-503  SH3_Sorbs1_1
cd11928453-501  SH3_SH3RF3_1
cd11923450-503  SH3_Sorbs2_2
cd11948452-501  SH3_GRAP_N
cd11809452-500  SH3_srGAP
cd11784452-500  SH3_SH3RF2_3
cd11871454-503  SH3_p67phox_N
cd11947452-501  SH3_GRAP2_N
cd11952451-499  SH3_iASPP
cd11775449-501  SH3_Sla1p_3
cd12064450-501  SH3_GRAF
cd11889450-500  SH3_Cyk3p-like
cd11884451-501  SH3_MYO15
cd12044453-500  SH3_SKAP1
cd11869453-503  SH3_p40phox
cd11886451-499  SH3_BOI
cd11921455-503  SH3_Vinexin_1
cd11829453-500  SH3_GAS7
cd12074452-502  SH3_Tks5_1
cd11922452-503  SH3_Sorbs1_2
cd12045454-500  SH3_SKAP2
cd11896450-501  SH3_SNX33
cd11904451-500  SH3_Nck1_3
cd11866453-500  SH3_SKAP1-like
cd11810450-499  SH3_RUSC1_like
cd11956452-500  SH3_srGAP4
cd11779450-502  SH3_Irsp53_BAIAP2L
cd11931453-500  SH3_SH3RF3_2
cd11872452-500  SH3_DOCK_AB
cd11865450-501  SH3_Nbp2-like
cd12015452-502  SH3_Tks_1
cd11813453-501  SH3_SGSM3
cd11844453-501  SH3_CAS
cd11978452-501  SH3_VAV3_2
cd11940450-501  SH3_ARHGEF5_19
cd11985452-501  SH3_Stac2_C
cd11828450-500  SH3_ARHGEF9_like
cd11954451-498  SH3_ASPP1
cd12007452-500  SH3_Yes
cd11993445-501  SH3_Intersectin1_4
cd12077449-484  SH3_Tks5_2
cd11761450-501  SH3_FCHSD_1
cd11977452-501  SH3_VAV2_2
cd12006452-500  SH3_Fyn_Yrk
cd11953451-498  SH3_ASPP2
cd12024457-499  SH3_NoxO1_2
cd11771453-501  SH3_Pex13p_fungal
cd11861451-485  SH3_DLG-like
cd11966450-500  SH3_ASAP2
cd12139450-503  SH3_Bin1
cd11855450-501  SH3_Sho1p
cd11986452-500  SH3_Stac3_1
cd11864452-502  SH3_PEX13_eumet
cd12000453-498  SH3_CASS4
cd11930453-500  SH3_SH3RF1_2
cd11988453-501  SH3_Intersectin2_1
cd11912450-501  SH3_Bzz1_1
cd12075449-484  SH3_Tks4_1
cd11858453-501  SH3_Myosin-I_fungi
cd11794451-500  SH3_DNMBP_N1
cd11797451-496  SH3_DNMBP_N4
cd11788450-483  SH3_RasGAP
cd11795451-501  SH3_DNMBP_N2
cd11932453-496  SH3_SH3RF2_2
cd11769450-501  SH3_CSK
cd11801452-500  SH3_JIP1_like
cd12001453-508  SH3_BCAR1
cd12021453-501  SH3_p47phox_1
cd12002453-501  SH3_NEDD9
cd12004451-500  SH3_Lyn
cd11911450-483  SH3_CIP4-like
cd12018452-500  SH3_Tks4_4
cd12009451-500  SH3_Blk
cd11808450-501  SH3_Alpha_Spectrin
cd12051452-500  SH3_DOCK1_5_A
cd11847450-500  SH3_Brk


Ontology Information


   
HPRD ID14788
Molecular ClassAdapter molecule
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO