CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
20812987	2010	Cell line : - Source : Nanfang Hospital tumour tissue bank. Sample Type : CRC tumor and Normal tissue No. of Sample : 150 Stage : -	2-D Gelelectrophoresis, and mass spectrometry,Western blotting,immunohistochemistry	Up-regulation	-	ACTG1 differentially expressed in colorectal cancer

Gene Details

Chromosome: 17; NC_000017.10 (79476997..79479892, complement)
View Larger Image

Gene Type	protein coding
Gene Family	-
Description	Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]
Chromosome	17
Location	17q25
Start	81509971
End	81512866
Strand	-
Gene Sequence	>gi\|568815581:c81512866-81509971 Homo sapiens chromosome 17, GRCh38.p2 Primary Assembly GCGCGCCGCCGGGCCGCGCGGGCGCGCCGCTTCCGCTTAAATAACGGCGGGGGAGGCCGCGGTCGGTCTC AGTCGCCGCTGCCAGCTCTCGCACTCTGTTCTTCCGCCGCTCCGCCGTCGCGTTTCTCTGCCGGTGAGCG CCCCGCCCCGGGGCCTGAGCTGGACGTCGCAGGCCTGCGCCCCCCGACCCCGGCTGGCCCCGCTTCCAGC TGCCGAGGCCTCGTCGCGCCTTCCCCGGGAACAAAAGGCGGGGTGGGCCGGGTCAGGCGGACGGGGCTGG GGGGGCGCCGGGGGTCCAGGGCGGGGCCCGGCCGCAGTGCAGACTTCCGAGCCGTGGACGTTACGTAAAA GGCCCGGCCTTCGGTTCCAGGCGGTTGCGATCTTGGAGGCCACGGCCGCTGGGGTTGGGGCAGGGCCGAG GCTTCCCCGCGGGAGGGCATTAGGTGGCTGTGGGGAGGGGACCGTGTTACAGACGCGCCCGCCTGAGTCC ATCCTTTTCCGGGCAGGTCGCAATGGAAGAAGAGATCGCCGCGCTGGTCATTGACAATGGCTCCGGCATG TGCAAAGCTGGTTTTGCTGGGGACGACGCTCCCCGAGCCGTGTTTCCTTCCATCGTCGGGCGCCCCAGAC ACCAGGTGAGTGGATGGCGCCGCGGGGCTCCTGGGTTCTGCGTTGCGGGGTGGGTTCGGTGTCGCCGGCG AGGCTGACGGGTCGTCCCCTGCAGGGCGTCATGGTGGGCATGGGCCAGAAGGACTCCTACGTGGGCGACG AGGCCCAGAGCAAGCGTGGCATCCTGACCCTGAAGTACCCCATTGAGCATGGCATCGTCACCAACTGGGA CGACATGGAGAAGATCTGGCACCACACCTTCTACAACGAGCTGCGCGTGGCCCCGGAGGAGCACCCAGTG CTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACAGAGAGAAGATGACTCAGGTGAGGCTCGGCCGAC GCCCGTGCTCCTCCCGTCCTTTCCCCAGTCATTTTCTGCCCGGCTTGATTTCTGACATTTAAGTGTTTCT TTCGCTGTTCCAGGCTCTGTTCCTCTCCCGGCATTTCCTCCCTGAAGCCTCCAGGTTTCTCATTTGGTTT CTGCCTGCGTTCTTTTCTTTTCTCCACACATCACACTGGCATGCAGCATGTTGTGGCGTGTGAGCATGGG GTGGCCGTGGGTCTCTGTCCCTGACTAAGCCGCCCCTTGTCCCTTCTCAGATTATGTTTGAGACCTTCAA CACCCCGGCCATGTACGTGGCCATCCAGGCCGTGCTGTCCCTCTACGCCTCTGGGCGCACCACTGGCATT GTCATGGACTCTGGAGACGGGGTCACCCACACGGTGCCCATCTACGAGGGCTACGCCCTCCCCCACGCCA TCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACCGACTACCTCATGAAGATCCTCACTGAGCGAGGCTA CAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGCGACATCAAGGAGAAGCTGTGCTACGTCGCCCTG GACTTCGAGCAGGAGATGGCCACCGCCGCATCCTCCTCTTCTCTGGAGAAGAGCTACGAGCTGCCCGATG GCCAGGTCATCACCATTGGCAATGAGCGGTTCCGGTGTCCGGAGGCGCTGTTCCAGCCTTCCTTCCTGGG TAGGTGTTGTGAGCTAAAGGTTTCTACTCTTACATCCTCGGTGACACAGCATCACTAAGGGAGGGCTCTG TCCCCTAGGTATGGAATCTTGCGGCATCCACGAGACCACCTTCAACTCCATCATGAAGTGTGACGTGGAC ATCCGCAAAGACCTGTACGCCAACACGGTGCTGTCGGGCGGCACCACCATGTACCCGGGCATTGCCGACA GGATGCAGAAGGAGATCACCGCCCTGGCGCCCAGCACCATGAAGATCAAGGTGAGTCGAGGGGTTGGTGG CCCTCTGCCTGGCTCGGGAGAGCTGACTGGGGGGCGCTCTGTGAGCTGAAGCCGTGCCTGGCTGTCTTTG CAGATCATCGCACCCCCAGAGCGCAAGTACTCGGTGTGGATCGGTGGCTCCATCCTGGCCTCACTGTCCA CCTTCCAGCAGATGTGGATTAGCAAGCAGGAGTACGACGAGTCGGGCCCCTCCATCGTCCACCGCAAATG CTTCTAAACGGACTCAGCAGATGCGTAGCATTTGCTGCATGGGTTAATTGAGAATAGAAATTTGCCCCTG GCAAATGCACACACCTCATGCTAGCCTCACGAAACTGGAATAAGCCTTCGAAAAGAAATTGTCCTTGAAG CTTGTATCTGATATCAGCACTGGATTGTAGAACTTGTTGCTGATTTTGACCTTGTATTGAAGTTAACTGT TCCCCTTGGTATTTGTTTAATACCCTGTACATATCTTTGAGTTCAACCTTTAGTACGTGTGGCTTGGTCA CTTCGTGGCTAAGGTAAGAACGTGCTTGTGGAAGACAAGTCTGTGGCTTGGTGAGTCTGTGTGGCCAGCA GCCTCTGATCTGTGCAGGGTATTAACGTGTCAGGGCTGAGTGTTCTGGGATTTCTCTAGAGGCTGGCAAG AACCAGTTGTTTTGTCTTGCGGGTCTGTCAGGGTTGGAAAGTCCAAGCCGTAGGACCCAGTTTCCTTTCT TAGCTGATGTCTTTGGCCAGAACACCGTGGGCTGTTACTTGCTTTGAGTTGGAAGCGGTTTGCATTTACG CCTGTAAATGTATTCATTCTTAATTTATGTAAGGTTTTTTTTGTACGCAATTCTCGATTCTTTGAAGAGA TGACAACAAATTTTGGTTTTCTACTGTTATGTGAGAACATTAGGCCCCAGCAACACGTCATTGTGTAAGG AAAAATAAAAGTGCTGCCGTAACCAA Download Select all
Length	2896
OMIM ID	102560
HGNC ID	HGNC:144
Unigene ID	Hs.514581
Ensembl ID	ENSG00000184009
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001614.3
Exon	join(1..133,507..635,725..964,1241..1679,1759..1940, 2034..2896)
mRNA Sequence	>71 GCGCGCCGCCGGGCCGCGCGGGCGCGCCGCTTCCGCTTAAATAACGGCGGGGGAGGCCGCGGTC GGTCTCAGTCGCCGCTGCCAGCTCTCGCACTCTGTTCTTCCGCCGCTCCGCCGTCGCGTTTCTC TGCCGGTCGCAATGGAAGAAGAGATCGCCGCGCTGGTCATTGACAATGGCTCCGGCATGTGCAA AGCTGGTTTTGCTGGGGACGACGCTCCCCGAGCCGTGTTTCCTTCCATCGTCGGGCGCCCCAGA CACCAGGGCGTCATGGTGGGCATGGGCCAGAAGGACTCCTACGTGGGCGACGAGGCCCAGAGCA AGCGTGGCATCCTGACCCTGAAGTACCCCATTGAGCATGGCATCGTCACCAACTGGGACGACAT GGAGAAGATCTGGCACCACACCTTCTACAACGAGCTGCGCGTGGCCCCGGAGGAGCACCCAGTG CTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACAGAGAGAAGATGACTCAGATTATGTTTG AGACCTTCAACACCCCGGCCATGTACGTGGCCATCCAGGCCGTGCTGTCCCTCTACGCCTCTGG GCGCACCACTGGCATTGTCATGGACTCTGGAGACGGGGTCACCCACACGGTGCCCATCTACGAG GGCTACGCCCTCCCCCACGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACCGACTACC TCATGAAGATCCTCACTGAGCGAGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCG CGACATCAAGGAGAAGCTGTGCTACGTCGCCCTGGACTTCGAGCAGGAGATGGCCACCGCCGCA TCCTCCTCTTCTCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAATG AGCGGTTCCGGTGTCCGGAGGCGCTGTTCCAGCCTTCCTTCCTGGGTATGGAATCTTGCGGCAT CCACGAGACCACCTTCAACTCCATCATGAAGTGTGACGTGGACATCCGCAAAGACCTGTACGCC AACACGGTGCTGTCGGGCGGCACCACCATGTACCCGGGCATTGCCGACAGGATGCAGAAGGAGA TCACCGCCCTGGCGCCCAGCACCATGAAGATCAAGATCATCGCACCCCCAGAGCGCAAGTACTC GGTGTGGATCGGTGGCTCCATCCTGGCCTCACTGTCCACCTTCCAGCAGATGTGGATTAGCAAG CAGGAGTACGACGAGTCGGGCCCCTCCATCGTCCACCGCAAATGCTTCTAAACGGACTCAGCAG ATGCGTAGCATTTGCTGCATGGGTTAATTGAGAATAGAAATTTGCCCCTGGCAAATGCACACAC CTCATGCTAGCCTCACGAAACTGGAATAAGCCTTCGAAAAGAAATTGTCCTTGAAGCTTGTATC TGATATCAGCACTGGATTGTAGAACTTGTTGCTGATTTTGACCTTGTATTGAAGTTAACTGTTC CCCTTGGTATTTGTTTAATACCCTGTACATATCTTTGAGTTCAACCTTTAGTACGTGTGGCTTG GTCACTTCGTGGCTAAGGTAAGAACGTGCTTGTGGAAGACAAGTCTGTGGCTTGGTGAGTCTGT GTGGCCAGCAGCCTCTGATCTGTGCAGGGTATTAACGTGTCAGGGCTGAGTGTTCTGGGATTTC TCTAGAGGCTGGCAAGAACCAGTTGTTTTGTCTTGCGGGTCTGTCAGGGTTGGAAAGTCCAAGC CGTAGGACCCAGTTTCCTTTCTTAGCTGATGTCTTTGGCCAGAACACCGTGGGCTGTTACTTGC TTTGAGTTGGAAGCGGTTTGCATTTACGCCTGTAAATGTATTCATTCTTAATTTATGTAAGGTT TTTTTTGTACGCAATTCTCGATTCTTTGAAGAGATGACAACAAATTTTGGTTTTCTACTGTTAT GTGAGAACATTAGGCCCCAGCAACACGTCATTGTGTAAGGAAAAATAAAAGTGCTGCCGTAACC AAAAAAAAAAAAAAAAAAAA Download Select all
Length	2004

CDS Information

Location	join(513..635,725..964,1241..1679,1759..1940,2034..2177)
CDS Sequence	>gi\|316659407:140-1267 Homo sapiens actin, gamma 1 (ACTG1), transcript variant 2, mRNA ATGGAAGAAGAGATCGCCGCGCTGGTCATTGACAATGGCTCCGGCATGTGCAAAGCTGGTTTTGCTGGGG ACGACGCTCCCCGAGCCGTGTTTCCTTCCATCGTCGGGCGCCCCAGACACCAGGGCGTCATGGTGGGCAT GGGCCAGAAGGACTCCTACGTGGGCGACGAGGCCCAGAGCAAGCGTGGCATCCTGACCCTGAAGTACCCC ATTGAGCATGGCATCGTCACCAACTGGGACGACATGGAGAAGATCTGGCACCACACCTTCTACAACGAGC TGCGCGTGGCCCCGGAGGAGCACCCAGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACAGAGA GAAGATGACTCAGATTATGTTTGAGACCTTCAACACCCCGGCCATGTACGTGGCCATCCAGGCCGTGCTG TCCCTCTACGCCTCTGGGCGCACCACTGGCATTGTCATGGACTCTGGAGACGGGGTCACCCACACGGTGC CCATCTACGAGGGCTACGCCCTCCCCCACGCCATCCTGCGTCTGGACCTGGCTGGCCGGGACCTGACCGA CTACCTCATGAAGATCCTCACTGAGCGAGGCTACAGCTTCACCACCACGGCCGAGCGGGAAATCGTGCGC GACATCAAGGAGAAGCTGTGCTACGTCGCCCTGGACTTCGAGCAGGAGATGGCCACCGCCGCATCCTCCT CTTCTCTGGAGAAGAGCTACGAGCTGCCCGATGGCCAGGTCATCACCATTGGCAATGAGCGGTTCCGGTG TCCGGAGGCGCTGTTCCAGCCTTCCTTCCTGGGTATGGAATCTTGCGGCATCCACGAGACCACCTTCAAC TCCATCATGAAGTGTGACGTGGACATCCGCAAAGACCTGTACGCCAACACGGTGCTGTCGGGCGGCACCA CCATGTACCCGGGCATTGCCGACAGGATGCAGAAGGAGATCACCGCCCTGGCGCCCAGCACCATGAAGAT CAAGATCATCGCACCCCCAGAGCGCAAGTACTCGGTGTGGATCGGTGGCTCCATCCTGGCCTCACTGTCC ACCTTCCAGCAGATGTGGATTAGCAAGCAGGAGTACGACGAGTCGGGCCCCTCCATCGTCCACCGCAAAT GCTTCTAA Download Select all
CCDS ID	CCDS11782.1

Protein Information

Protein ID	NP_001186883.1
Protein Name	Actin, gamma 1
Molecular Wt. (Da)	41662
Protein Sequence	>71 MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGI LTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFN TPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKI LTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFR CPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITAL APSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF Download Select all
Length	375
Uniprot ID	Q8NE71
Ensembl Protein ID	ENSP00000313603

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
C	Glutathionylation	217
K	Acetylation	328
K	Acetylation	191
K	Acetylation	61
K	Acetylation	326
Y	Phosphorylation	218
T	Phosphorylation	201
S	Phosphorylation	233
S	Phosphorylation	239
S	Phosphorylation	323
T	Phosphorylation	297

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
60	ACTB	32	NP_001092.1	yeast 2-hybrid	16189514
1072	CFL1	3261	NP_005498.1	yeast 2-hybrid	16189514
1073	CFL2	3262	NP_068733.1	yeast 2-hybrid	16189514
3692	EIF6	4221	NP_852133.1	yeast 2-hybrid	16169070
4687	NCF1	1990	NP_000256.3	in vitro	1 575 905 515 618 540
5217	PFN2	1451	NP_444252.1	yeast 2-hybrid	16169070
5800	PTPRO	2784	NP_109592.1	yeast 2-hybrid	16169070
6456	SH3GL2	5125	NP_003017.1	yeast 2-hybrid	16169070
6487	ST3GAL3	5930	NP_777623.1	yeast 2-hybrid	16169070
8936	WASF1	5434	NP_003922.1	in vitro;in vivo	10970852
11098	PRSS23	7149	NP_009104.1	yeast 2-hybrid	16169070
55729	ATF7IP	9811	NP_060649.3	yeast 2-hybrid	15231748

Pathway Information

Pathway Name	Pathway ID
Adherens junction	hsa04520
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	hsa05412
Bacterial invasion of epithelial cells	hsa05100
Dilated cardiomyopathy	hsa05414
Focal adhesion	hsa04510
Hippo signaling pathway	hsa04390
Hypertrophic cardiomyopathy (HCM)	hsa05410
Influenza A	hsa05164
Leukocyte transendothelial migration	hsa04670
Oxytocin signaling pathway	hsa04921
Pathogenic Escherichia coli infection	hsa05130
Phagosome	hsa04145
Platelet activation	hsa04611
Proteoglycans in cancer	hsa05205
Rap1 signaling pathway	hsa04015
Regulation of actin cytoskeleton	hsa04810
Salmonella infection	hsa05132
Shigellosis	hsa05131
Thyroid hormone signaling pathway	hsa04919
Tight junction	hsa04530
Vibrio cholerae infection	hsa05110
Viral myocarditis	hsa05416

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd00012	8-181	NBD_sugar-kinase_HSP70_actin
cl17037	8-181	NBD_sugar-kinase_HSP70_actin superfamily
PTZ00281	1-375	PTZ00281
PTZ00004	1-375	PTZ00004
PTZ00466	8-375	PTZ00466
PTZ00452	1-375	PTZ00452
COG5277	1-375	COG5277
pfam00022	3-375	Actin
smart00268	6-375	ACTIN
PTZ00280	7-372	PTZ00280

Ontology Information

HPRD ID	9139
Molecular Class	Structural protein
Molecular Function	Translation regulator activity (GO:0045182)
Biological Process	Protein metabolism (GO:0019538)

SNP Information

View SNP Geneview Report