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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22188913    | 2012 | Cell line : - Source : Peking Union Medical College Hospital Sample Type : CRC tumor No. of Sample : 24 Stage : TNM Stage I,II | Microarray analysis | Down-regulation | - | - |
| 25860875    | 2015 | Cell line : DLD 1, HT 29, LoVo, NCI H508, and Caco 2, SW480 Source : JCRB Cell Bank (Osaka, Japan), ATCC Sample Type : - No. of Sample : - Stage : - | Transfection,RNA interference ,Immunofluorescence microscopy,Western blotting | Down-regulation | - | ZYX defective binding to ACTN4, which occupies focal adhesions instead of ACTN1, induces the formation of immature focal adhesions, resulting in the enhancement of cell motility and invasion. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | EF-hand domain containing |
| Description | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]   | Chromosome | 14 |
| Location | 14q24.1 |
| Start | 69340840   |
| End | 69446083   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 105244   |
| OMIM ID | 102575    |
| HGNC ID | HGNC:163    |
| Unigene ID | Hs.235750    |
| Ensembl ID | ENSG00000072110    |
| PharmGKB ID | PA24    |
mRNA Information
| mRNA ID | NM_001130005.1 |
|---|---|
| Exon | join(1..415,53695..53809,58242..58361,67125..67211, 69325..69412,69971..70049,74631..74712,76805..76890, 85620..85712,87084..87314,89081..89228,93792..93942, 94484..94592,95059..95199,96312..96494,96775..96909, 98378..98557,99259..99405,100844..100909,102127..102285, 104350..105244)   | mRNA Sequence |    Download   Select all |
| Length | 3728   |
CDS Information
| Location | 311..2974 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS45129.1 |    
Protein Information
| Protein ID | NP_001123477.1 |
|---|---|
| Protein Name | actinin, alpha 1 |
| Molecular Wt. (Da) | 102579 |
| Protein Sequence |    Download   Select all |
| Length | 887   |
| Uniprot ID | P16422 |    
| Ensembl Protein ID | ENSP00000263735   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 12 |
| Y | Dephosphorylation | 12 |
| Y | Phosphorylation | 193;- |
| S | Phosphorylation | 140;- |
| K | Acetylation | 95 |
| K | Acetylation | 195 |
| K | Acetylation | 676 |
| T | Phosphorylation | 50 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 135 |    ADORA2A |    43 |    NP_000666.2 |    in vitro;yeast 2-hybrid |    12837758    |
| 815 |    CAMK2A |    6532 |    NP_057065.2 |    yeast 2-hybrid |    12223541    |
| 2395 |    FXN |    6013 |    NP_000135.2 |    yeast 2-hybrid |    16713569    |
| 4110 |    MAGEA11 |    2281 |    NP_005357.2 |    yeast 2-hybrid |    16189514    |
| 6311 |    ATXN2 |    3307 |    NP_002964.3 |    yeast 2-hybrid |    16713569    |
| 6714 |    SRC |    1819 |    NP_005408.1 |    in vitro;in vivo |    16291744    |
| 7414 |    VCL |    1900 |    NP_054706.1 |    in vitro |    15988023    |
| 7518 |    XRCC4 |    15951 |    NP_071801.1 |    yeast 2-hybrid |    16189514    |
| 8161 |    COIL |    2605 |    NP_004636.1 |    yeast 2-hybrid |    16713569    |
| 8328 |    GFI1B |    5088 |    NP_004179.3 |    yeast 2-hybrid |    16713569    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adherens junction |    hsa04520 |    
| Amoebiasis |    hsa05146 |    
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) |    hsa05412 |    
| Focal adhesion |    hsa04510 |    
| Leukocyte transendothelial migration |    hsa04670 |    
| Regulation of actin cytoskeleton |    hsa04810 |    
| Systemic lupus erythematosus |    hsa05322 |    
| Tight junction |    hsa04530 |    
| Viral carcinogenesis |    hsa05203 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00176 | 395-622  | SPEC |
| cl02488 | 395-622  | SPEC superfamily |
| cd00014 | 145-249  | CH |
| cl00030 | 145-249  | CH superfamily |
| cd00014 | 33-135  | CH |
| cl00030 | 33-135  | CH superfamily |
| cd00176 | 277-498  | SPEC |
| cl02488 | 277-498  | SPEC superfamily |
| cd00051 | 750-817  | EFh |
| cl08302 | 750-817  | EFh superfamily |
| pfam00307 | 147-250  | CH |
| pfam00435 | 394-499  | Spectrin |
| smart00033 | 148-245  | CH |
| pfam00307 | 34-134  | CH |
| smart00033 | 35-133  | CH |
| smart00150 | 397-498  | SPEC |
| cd00176 | 510-735  | SPEC |
| pfam00435 | 509-620  | Spectrin |
| pfam11971 | 154-228  | CAMSAP_CH |
| pfam00435 | 274-384  | Spectrin |
| pfam00435 | 634-733  | Spectrin |
| cl02488 | 634-733  | SPEC superfamily |
| smart00150 | 513-618  | SPEC |
| pfam13405 | 750-779  | EF-hand_6 |
| cl23634 | 750-779  | EF-hand_6 superfamily |
| smart00054 | 750-778  | EFh |
| cl23347 | 750-778  | EFh superfamily |
| pfam00036 | 750-778  | EF-hand_1 |
| cl23489 | 750-778  | EF-hand_1 superfamily |
| pfam08726 | 822-888  | EFhand_Ca_insen |
| pfam13499 | 758-816  | EF-hand_7 |
| COG5069 | 29-292  | SAC6 |
| PTZ00184 | 740-849  | PTZ00184 |
| PTZ00183 | 742-850  | PTZ00183 |
| COG5126 | 743-852  | FRQ1 |
| COG5126 | 749-822  | FRQ1 |
| COG5069 | 37-210  | SAC6 |
| COG0419 | 250-516  | SbcC |
| COG0497 | 427-516  | RecN |
Ontology Information
| HPRD ID | 7519 |    
|---|---|
| Molecular Class | Cytoskeletal associated protein |
| Molecular Function | Structural constituent of cytoskeleton (GO:0005200) |
| Biological Process | Cell growth and/or maintenance (GO:0008151)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
