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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19089928 | 2009 | Cell line : Thirty-two human colorectal cancer cell lines (SNU-61, SNU-
81, SNU-175, SNU-283, SNU-407, SNU-503, SNU-769A, SNU-
769B, SNU-1033, SNU-1040, SNU-1047, SNU-1197A, SNU-C1,
SNU-C2A, SNU-C4, SNU-C5, Caco-2, COLO201, COLO205,
COLO320, DLD1, HCT-8, HCT-15, HCT-116, HT-29, Lovo,
LS174T, NCI-H716, SW403, SW480, SW1116 and WiDr) and 3
human gastric cancer cell lines (SNU-484, SNU-719 and MKN1)
Source : Korean Cell Line Bank. Tissue sample from Seoul National University Hospital. Sample Type : CRC tumor and normal tissues No. of Sample : 76 primary colorectal cancer tissues and available 47 corresponding normal tissues Stage : - | Reverse transcription-PCR analysis,Quantitative real-time RT-PCR analysis,Sodium bisulfite treatment,Methylation-specific PCR analysis,Bisulfite-modified DNA sequencing analysis. | Hypermethylation | - | ADAM23 may be down-regulated by aberrant promoter hypermethylation during the progression of colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | ADAM metallopeptidase domain containing |
| Description | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013] | Chromosome | 2 |
| Location | 2q33 |
| Start | 207308268 |
| End | 207485854 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 177587 |
| OMIM ID | 603710 |
| HGNC ID | HGNC:202 |
| Unigene ID | Hs.370287 |
| Ensembl ID | ENSG00000114948 |
| PharmGKB ID | PA24519 |
Protein Information
| Protein ID | NP_003803.1 |
|---|---|
| Protein Name | ADAM metallopeptidase domain 23 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 832 |
| Uniprot ID | Q9NQ30 |
| Ensembl Protein ID | ENSP00000370810 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 707 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5621 | PRNP | 1453 | NP_000302.1 | in vivo | 15146195 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04269 | 299-494 | ZnMc_adamalysin_II_like |
| cl00064 | 299-494 | ZnMc superfamily |
| smart00608 | 587-726 | ACR |
| cl15456 | 587-726 | ADAM_CR superfamily |
| pfam08516 | 588-708 | ADAM_CR |
| pfam01562 | 110-249 | Pep_M12B_propep |
| cl03265 | 110-249 | Pep_M12B_propep superfamily |
| pfam00200 | 511-586 | Disintegrin |
| cl10507 | 511-586 | Disintegrin superfamily |
| smart00050 | 511-585 | DISIN |
| cd04267 | 299-484 | ZnMc_ADAM_like |
| cd04273 | 299-493 | ZnMc_ADAMTS_like |
| pfam13582 | 328-417 | Reprolysin_3 |
| pfam13688 | 303-473 | Reprolysin_5 |
| cd00203 | 299-484 | ZnMc |
| cd04272 | 300-492 | ZnMc_salivary_gland_MPs |
| pfam13574 | 328-484 | Reprolysin_2 |
| pfam01421 | 299-496 | Reprolysin |
Ontology Information
| HPRD ID | 4468 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Protein tyrosine phosphatase activity (GO:0004725) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.