Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ADAM8 | 101 | ADAM metallopeptidase domain 8 | 10 | CD156, MS2, CD156a |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25098630 | 2014 | Cell line : - Source : Sixth Affiliated Hospital of Sun Yat-sen University. Sample Type : - No. of Sample : - Stage : - | Tissue microarray, real time RT-PCR, Immunohistochemistry and western blotting | Up-regulation | - | ADAM8 is overexpressed in CRC, promotes cell growth and correlates with worse OS and DFS |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | ADAM metallopeptidase domain containing, "CD molecules" |
| Description | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. | Chromosome | 10 |
| Location | 10q26.3 |
| Start | 133262416 |
| End | 133276903 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 14488 |
| OMIM ID | 602267 |
| HGNC ID | HGNC:215 |
| Unigene ID | Hs.501574 |
| Ensembl ID | ENSG00000151651 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001164490.1 |
|---|---|
| Exon | join(1..132,2669..2745,2875..2953,3066..3142,3474..3650, 3885..3947,4038..4106,4319..4488,4630..4711,4950..5098, 5199..5376,5615..5704,5834..6023,6099..6168,6394..6544, 7375..7459,8042..8156,8786..8975,9487..9552,13671..14488) | mRNA Sequence | Download Select all |
| Length | 3316 |
CDS Information
| Location | join(87..132,2669..2745,2875..2953,3066..3142,3474..3650, 3885..3947,4038..4106,4319..4488,4630..4711,4950..5098, 5199..5376,5615..5704,5834..6023,6099..6168,6394..6544, 7375..7459,8042..8156,8786..8975,9487..9552,13671..13748) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS58102.1 |
Protein Information
| Protein ID | NP_001100.3 |
|---|---|
| Protein Name | ADAM metallopeptidase domain 8 |
| Molecular Wt. (Da) | 87059 |
| Protein Sequence | Download Select all |
| Length | 824 |
| Uniprot ID | P43694 |
| Ensembl Protein ID | ENSP00000334458 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 4DD8 |
|---|---|
| Resolution | 2.1 |
| Method | X-RAY DIFFRACTION |
| Chains | A, B, |
| Molecule | Disintegrin and metalloproteinase domain-containing protein 8 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04269 | 200-398 | ZnMc_adamalysin_II_like |
| cl00064 | 200-398 | ZnMc superfamily |
| pfam01562 | 29-155 | Pep_M12B_propep |
| cl03265 | 29-155 | Pep_M12B_propep superfamily |
| cd04267 | 200-389 | ZnMc_ADAM_like |
| cd04273 | 200-396 | ZnMc_ADAMTS_like |
| pfam00200 | 417-492 | Disintegrin |
| cl10507 | 417-492 | Disintegrin superfamily |
| smart00050 | 417-491 | DISIN |
| smart00608 | 494-605 | ACR |
| cl15456 | 494-605 | ADAM_CR superfamily |
| pfam13582 | 225-345 | Reprolysin_3 |
| cd00203 | 200-388 | ZnMc |
| cd04272 | 201-396 | ZnMc_salivary_gland_MPs |
| pfam13688 | 199-377 | Reprolysin_5 |
| pfam08516 | 494-561 | ADAM_CR |
| pfam13583 | 200-383 | Reprolysin_4 |
| pfam13574 | 220-380 | Reprolysin_2 |
| cd04271 | 217-390 | ZnMc_ADAM_fungal |
| cd04270 | 204-380 | ZnMc_TACE_like |
| pfam12877 | 682-809 | DUF3827 |
| cl15135 | 682-809 | DUF3827 superfamily |
| cd11375 | 328-367 | Peptidase_M54 |
| cd04276 | 314-344 | ZnMc_MMP_like_2 |
| pfam01421 | 200-400 | Reprolysin |
| PHA03378 | 706-824 | PHA03378 |
| PRK14951 | 714-824 | PRK14951 |
| PHA03247 | 692-824 | PHA03247 |
| PHA03247 | 687-814 | PHA03247 |
| PRK07764 | 706-823 | PRK07764 |
| PRK14950 | 705-796 | PRK14950 |
| pfam07174 | 706-803 | FAP |
| PRK14951 | 681-810 | PRK14951 |
| PHA03247 | 707-824 | PHA03247 |
| PHA03247 | 692-824 | PHA03247 |
| PHA03247 | 690-821 | PHA03247 |
| PTZ00436 | 707-818 | PTZ00436 |
| PRK12323 | 685-824 | PRK12323 |
| pfam13388 | 704-817 | DUF4106 |
| PRK14950 | 706-824 | PRK14950 |
| PRK12323 | 707-823 | PRK12323 |
| pfam07174 | 739-824 | FAP |
| PRK03427 | 704-809 | PRK03427 |
| PHA03247 | 690-824 | PHA03247 |
| PRK07764 | 706-824 | PRK07764 |
| PHA03247 | 685-822 | PHA03247 |
| PRK07003 | 711-824 | PRK07003 |
| pfam09770 | 701-824 | PAT1 |
| PHA03247 | 687-824 | PHA03247 |
| PHA03247 | 679-824 | PHA03247 |
| PRK12323 | 705-824 | PRK12323 |
| PRK07764 | 705-802 | PRK07764 |
| PRK07994 | 703-810 | PRK07994 |
| PRK07764 | 703-824 | PRK07764 |
| PHA03269 | 681-768 | PHA03269 |
| PHA03378 | 692-824 | PHA03378 |
| PRK00708 | 729-824 | PRK00708 |
| PHA03247 | 677-824 | PHA03247 |
| TIGR02927 | 740-815 | SucB_Actino |
| TIGR01645 | 690-823 | half-pint |
| PRK14950 | 726-823 | PRK14950 |
| PRK12373 | 684-810 | PRK12373 |
| PRK14954 | 711-808 | PRK14954 |
| PTZ00436 | 707-824 | PTZ00436 |
| PLN02983 | 744-821 | PLN02983 |
| pfam03154 | 715-818 | Atrophin-1 |
| PHA03247 | 718-821 | PHA03247 |
| PRK07764 | 706-824 | PRK07764 |
| PRK13700 | 735-824 | PRK13700 |
| PHA03378 | 701-824 | PHA03378 |
| PTZ00436 | 680-824 | PTZ00436 |
| pfam04652 | 698-798 | DUF605 |
| PLN02983 | 734-806 | PLN02983 |
| PRK12323 | 690-804 | PRK12323 |
| PRK12270 | 707-793 | kgd |
| PRK10905 | 707-809 | PRK10905 |
| PRK07994 | 736-824 | PRK07994 |
| PHA02682 | 748-811 | PHA02682 |
| PRK12323 | 690-823 | PRK12323 |
| PRK14951 | 705-804 | PRK14951 |
| PRK11633 | 717-822 | PRK11633 |
| pfam03154 | 690-824 | Atrophin-1 |
| PHA03379 | 703-823 | PHA03379 |
| PLN03209 | 685-811 | PLN03209 |
| pfam03276 | 684-788 | Gag_spuma |
| pfam03276 | 714-795 | Gag_spuma |
| PRK07764 | 706-804 | PRK07764 |
| pfam07223 | 704-821 | DUF1421 |
| PHA03247 | 711-814 | PHA03247 |
| PRK14950 | 729-821 | PRK14950 |
| pfam15279 | 683-786 | SOBP |
| PRK07003 | 706-814 | PRK07003 |
| PRK11633 | 707-793 | PRK11633 |
| PHA03307 | 679-799 | PHA03307 |
| pfam05518 | 679-799 | Totivirus_coat |
| pfam04503 | 689-821 | SSDP |
| PRK12323 | 706-817 | PRK12323 |
| PRK07764 | 705-813 | PRK07764 |
Ontology Information
| HPRD ID | 659 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Galactosyltransferase activity (GO:0008378) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.