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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ADAM9 | 8754 | ADAM metallopeptidase domain 9 | 8 | MDC9, KIAA0021, MCMP, Mltng |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 16336960 | 2006 | Cell line : HT29 Source : ATCC Sample Type : - No. of Sample : - Stage : - | Immunofluorescence microscopy,Immunohistochemistry | Up-regulation | - | Metalloprotease activity of ADAM9 mediates growth factor-induced endocytosis and dynamic recycling of E-cadherin and prevents E-cadherin degradation. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | ADAM metallopeptidase domain containing |
| Description | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010] | Chromosome | 8 |
| Location | 8p11.23 |
| Start | 38854505 |
| End | 38962780 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 108276 |
| OMIM ID | 602713 |
| HGNC ID | HGNC:216 |
| Unigene ID | Hs.591852 |
| Ensembl ID | ENSG00000168615 |
| PharmGKB ID | PA24534 |
Protein Information
| Protein ID | NP_003807.1 |
|---|---|
| Protein Name | ADAM metallopeptidase domain 9 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 819 |
| Uniprot ID | Q9UNA0 |
| Ensembl Protein ID | ENSP00000284987 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 815;- |
| T | Phosphorylation | 761;- |
| S | Phosphorylation | 758;- |
| Y | Phosphorylation | 769 |
| Y | Phosphorylation | 213 |
| Y | Phosphorylation | 213 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3655 | ITGA6 | 945 | NP_001073286.1 | in vitro | 15361064 |
| 3675 | ITGA3 | 5431 | NP_005492.1 | in vitro | 15361064 |
| 3685 | ITGAV | 1903 | NP_002201.1 | in vitro | 15361064 |
| 5580 | PRKCD | 1501 | NP_006245.2 | in vitro;in vivo | 9857183 |
| 7124 | TNF | 1855 | NP_000585.2 | in vitro | 9920899 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04269 | 212-404 | ZnMc_adamalysin_II_like |
| cl00064 | 212-404 | ZnMc superfamily |
| smart00608 | 500-636 | ACR |
| cl15456 | 500-636 | ADAM_CR superfamily |
| pfam01562 | 43-163 | Pep_M12B_propep |
| cl03265 | 43-163 | Pep_M12B_propep superfamily |
| pfam08516 | 501-617 | ADAM_CR |
| pfam00200 | 423-498 | Disintegrin |
| cl10507 | 423-498 | Disintegrin superfamily |
| smart00050 | 423-498 | DISIN |
| cd04273 | 212-403 | ZnMc_ADAMTS_like |
| cd04267 | 212-387 | ZnMc_ADAM_like |
| pfam13582 | 244-358 | Reprolysin_3 |
| pfam13688 | 211-383 | Reprolysin_5 |
| cd04272 | 213-402 | ZnMc_salivary_gland_MPs |
| pfam13574 | 234-386 | Reprolysin_2 |
| cd00203 | 212-393 | ZnMc |
| pfam13583 | 212-401 | Reprolysin_4 |
| cd04271 | 281-386 | ZnMc_ADAM_fungal |
| cd04270 | 310-401 | ZnMc_TACE_like |
| cd04268 | 287-357 | ZnMc_MMP_like |
| cd11375 | 345-392 | Peptidase_M54 |
| cd04276 | 329-357 | ZnMc_MMP_like_2 |
| pfam01421 | 212-406 | Reprolysin |
| smart00235 | 322-362 | ZnMc |
Ontology Information
| HPRD ID | 12547 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Antigen binding (GO:0003823) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.