Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ADAMTS18 | 170692 | ADAM metallopeptidase with thrombospondin type 1 motif, 18 | 16 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19806480 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 100 gastric cancers, 100 colorectal cancers, 70 pancreatic cancers, and equal number of adjacent normal tissues Stage : - | High-resolution melting analysis | Methylation | - | Epigenetic regulation of ADAMTS18 was associated with carcinogenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | ADAM metallopeptidases with thrombospondin type 1 motif |
| Description | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] | Chromosome | 16 |
| Location | 16q23 |
| Start | 77316025 |
| End | 77469011 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 152987 |
| OMIM ID | 607512 |
| HGNC ID | HGNC:17110 |
| Unigene ID | Hs.188746 |
| Ensembl ID | ENSG00000140873 |
| PharmGKB ID | PA24544 |
Protein Information
| Protein ID | NP_955387.1 |
|---|---|
| Protein Name | ADAM metallopeptidase with thrombospondin type 1 motif, 18 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 1221 |
| Uniprot ID | Q86UU0 |
| Ensembl Protein ID | ENSP00000335320 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04273 | 293-494 | ZnMc_ADAMTS_like |
| cl00064 | 293-494 | ZnMc superfamily |
| pfam05986 | 749-861 | ADAM_spacer1 |
| cl20316 | 749-861 | ADAM_spacer1 superfamily |
| cd04267 | 295-487 | ZnMc_ADAM_like |
| cd04269 | 294-494 | ZnMc_adamalysin_II_like |
| pfam01562 | 61-203 | Pep_M12B_propep |
| cl03265 | 61-203 | Pep_M12B_propep superfamily |
| cd04272 | 293-494 | ZnMc_salivary_gland_MPs |
| smart00209 | 592-643 | TSP1 |
| cl15278 | 592-643 | TSP_1 superfamily |
| cd00203 | 361-486 | ZnMc |
| pfam13688 | 298-473 | Reprolysin_5 |
| pfam13574 | 311-476 | Reprolysin_2 |
| pfam08686 | 1187-1219 | PLAC |
| cl07344 | 1187-1219 | PLAC superfamily |
| pfam13582 | 316-447 | Reprolysin_3 |
| pfam00090 | 593-643 | TSP_1 |
| cd04270 | 433-501 | ZnMc_TACE_like |
| smart00209 | 995-1049 | TSP1 |
| cl15278 | 995-1049 | TSP_1 superfamily |
| pfam13583 | 298-481 | Reprolysin_4 |
| smart00209 | 1059-1116 | TSP1 |
| cl15278 | 1059-1116 | TSP_1 superfamily |
| smart00209 | 938-992 | TSP1 |
| cl15278 | 938-992 | TSP_1 superfamily |
| smart00209 | 1131-1178 | TSP1 |
| cl15278 | 1131-1178 | TSP_1 superfamily |
| pfam00090 | 998-1020 | TSP_1 |
| cd04271 | 318-447 | ZnMc_ADAM_fungal |
| pfam00090 | 1059-1079 | TSP_1 |
| pfam01421 | 295-498 | Reprolysin |
| PTZ00441 | 991-1049 | PTZ00441 |
Ontology Information
| HPRD ID | 10612 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.