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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ADAMTS20 80070 ADAM metallopeptidase with thrombospondin type 1 motif, 20  12GON-1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25974029   2015Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 488

Stage : TNM Stage I-IV

Next generation sequencing,Mutational profiling and MSI testingMutation-ANGPTL4 might promote metastasis and might inhibit apoptosis of colorectal cancer cells by up-regulation of BMP7.


Gene Details



NC_000012.11 (43748012..43945724, complement)

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Gene Type protein coding
Gene Family ADAM metallopeptidases with thrombospondin type 1 motif
Description The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. [provided by RefSeq, Sep 2011]  
Chromosome 12
Location 12q12
Start 43748012  
End 43945724  
Strand -  
Gene Sequence

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Length 197713  
OMIM ID 611681   
HGNC ID HGNC:17178   
Unigene ID Hs.287554   
Ensembl ID -   
PharmGKB ID PA134901626   

mRNA Information


mRNA ID ?NM_025003.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS31778.2



Protein Information


      
Protein IDNP_079279.3
Protein NameADAM metallopeptidase with thrombospondin type 1 motif, 20
Molecular Wt. (Da)0
Protein Sequence

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Length 1910  
Uniprot IDQ86YD3
Ensembl Protein ID ENSP00000315635  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd04273259-464  ZnMc_ADAMTS_like
cl00064259-464  ZnMc superfamily
pfam086851712-1910  GON
cl073431712-1910  GON superfamily
cd04267259-456  ZnMc_ADAM_like
pfam05986721-840  ADAM_spacer1
cl20316721-840  ADAM_spacer1 superfamily
pfam0156240-186  Pep_M12B_propep
cl0326540-186  Pep_M12B_propep superfamily
cd04269259-465  ZnMc_adamalysin_II_like
cd00203259-455  ZnMc
smart00209559-611  TSP1
cl15278559-611  TSP_1 superfamily
cd04272260-463  ZnMc_salivary_gland_MPs
pfam13688258-416  Reprolysin_5
smart002091208-1264  TSP1
cl152781208-1264  TSP_1 superfamily
pfam13582280-414  Reprolysin_3
smart00209970-1023  TSP1
cl15278970-1023  TSP_1 superfamily
pfam00090560-610  TSP_1
pfam000901482-1525  TSP_1
cl152781482-1525  TSP_1 superfamily
pfam13583264-451  Reprolysin_4
smart002091028-1077  TSP1
cl152781028-1077  TSP_1 superfamily
smart002091362-1416  TSP1
cl152781362-1416  TSP_1 superfamily
TIGR03935249-427  fragilysin
smart002091481-1525  TSP1
pfam13574278-419  Reprolysin_2
PRK13267401-419  PRK13267
smart002091080-1135  TSP1
cl152781080-1135  TSP_1 superfamily
smart002091159-1182  TSP1
cl152781159-1182  TSP_1 superfamily
pfam000901028-1077  TSP_1
cd11375400-449  Peptidase_M54
pfam01421259-467  Reprolysin
PTZ004411208-1277  PTZ00441
smart00235389-445  ZnMc


Ontology Information


   
HPRD ID8609
Molecular ClassMetallo protease
Molecular FunctionDNA binding (GO:0003677)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO