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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ADAMTS9 56999 ADAM metallopeptidase with thrombospondin type 1 motif, 9  3KIAA1312 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19963134   2010Cell line : -

Source : -

Sample Type : CRC tumor and normal tissues

No. of Sample : 100 gastric cancers, 100 colorectal cancers, 70 pancreatic cancers, and an equal number of adjacent normal tissues

Stage : -

High-resolution melting analysisMethylation- ADAMTS9 methylation based on a large number of tumor samples and showing that epigenetic regulation of ADAMTS9 was associated with carcinogenesis.


Gene Details



NC_000003.11 (64501330..64673676, complement)

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Gene Type protein coding
Gene Family ADAM metallopeptidases with thrombospondin type 1 motif
Description This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]  
Chromosome 3
Location 3p14.1
Start 64501330  
End 64673676  
Strand -  
Gene Sequence

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Length 172347  
OMIM ID 605421   
HGNC ID HGNC:13202   
Unigene ID Hs.656071   
Ensembl ID ENSG00000163638   
PharmGKB ID PA24553   

mRNA Information


mRNA ID ?NM_182920.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS2903.1



Protein Information


      
Protein IDNP_891550.1
Protein NameADAM metallopeptidase with thrombospondin type 1 motif, 9
Molecular Wt. (Da)0
Protein Sequence

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Length 1935  
Uniprot IDQ9H7S9
Ensembl Protein ID ENSP00000332325  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd04273293-496  ZnMc_ADAMTS_like
cl00064293-496  ZnMc superfamily
pfam086851735-1935  GON
cl073431735-1935  GON superfamily
cd04267293-488  ZnMc_ADAM_like
pfam05986753-871  ADAM_spacer1
cl20316753-871  ADAM_spacer1 superfamily
cd04269293-497  ZnMc_adamalysin_II_like
cd00203293-487  ZnMc
pfam0156248-207  Pep_M12B_propep
cl0326548-207  Pep_M12B_propep superfamily
cd04272294-495  ZnMc_salivary_gland_MPs
pfam13688292-448  Reprolysin_5
pfam13582316-445  Reprolysin_3
smart00209591-642  TSP1
cl15278591-642  TSP_1 superfamily
pfam13574311-488  Reprolysin_2
cd04270298-501  ZnMc_TACE_like
smart002091239-1296  TSP1
cl152781239-1296  TSP_1 superfamily
smart002091001-1054  TSP1
cl152781001-1054  TSP_1 superfamily
smart002091186-1239  TSP1
cl152781186-1239  TSP_1 superfamily
pfam13583292-483  Reprolysin_4
smart002091562-1613  TSP1
cl152781562-1613  TSP_1 superfamily
pfam00090591-642  TSP_1
smart002091059-1103  TSP1
cl152781059-1103  TSP_1 superfamily
smart002091386-1440  TSP1
cl152781386-1440  TSP_1 superfamily
smart002091332-1384  TSP1
cl152781332-1384  TSP_1 superfamily
smart002091445-1499  TSP1
cl152781445-1499  TSP_1 superfamily
pfam000901188-1209  TSP_1
smart002091504-1555  TSP1
cl152781504-1555  TSP_1 superfamily
pfam000901247-1295  TSP_1
pfam000901617-1639  TSP_1
cl152781617-1639  TSP_1 superfamily
smart002091615-1676  TSP1
smart002091114-1166  TSP1
cl152781114-1166  TSP_1 superfamily
pfam000901562-1612  TSP_1
pfam01421293-499  Reprolysin
PTZ004411199-1317  PTZ00441
PTZ004411191-1229  PTZ00441


Ontology Information


   
HPRD ID9419
Molecular ClassMetallo protease
Molecular FunctionDeoxyribonuclease activity (GO:0004536)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO