Search results:
General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24172857 | 2014 | Cell line : - Source : University of California San Francisco (UCSF). Sample Type : CRC Tumor and adjecent normal tissue No. of Sample : - Stage : TNM Stage IV | Whole exome sequencing,microarray | Mutation | - | Colorectal Cancer Metastasis Signaling', containing 6 (ADCY2, ADCY9, APC, GNB5, K-ras and LRP6) mutated genes. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Adenylate cyclases |
| Description | Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008] | Chromosome | 16 |
| Location | 16p13.3 |
| Start | 4012650 |
| End | 4166186 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 153537 |
| OMIM ID | 603302 |
| HGNC ID | HGNC:240 |
| Unigene ID | Hs.391860 |
| Ensembl ID | - |
| PharmGKB ID | PA30 |
mRNA Information
| mRNA ID | XM_011522353.1 |
|---|---|
| Exon | join(224..496,701..2436,108628..108818,122676..122837, 123823..124040,127090..127192,132746..132954, 136911..137070,138556..138704,141476..141517, 162670..162799) | mRNA Sequence | Download Select all |
| Length | 3373 |
Protein Information
| Protein ID | XP_011520655.1 |
|---|---|
| Protein Name | adenylate cyclase 9 |
| Molecular Wt. (Da) | 110479 |
| Protein Sequence | Download Select all |
| Length | 1001 |
| Uniprot ID | P84022 |
| Ensembl Protein ID | ENSP00000332973 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 365;- |
| S | Phosphorylation | 354 |
| S | Phosphorylation | 357 |
| S | Phosphorylation | 1259 |
| S | Phosphorylation | 1257 |
| S | Phosphorylation | 1307 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adrenergic signaling in cardiomyocytes | hsa04261 |
| Aldosterone synthesis and secretion | hsa04925 |
| Bile secretion | hsa04976 |
| Calcium signaling pathway | hsa04020 |
| cAMP signaling pathway | hsa04024 |
| cGMP-PKG signaling pathway | hsa04022 |
| Chemokine signaling pathway | hsa04062 |
| Cholinergic synapse | hsa04725 |
| Circadian entrainment | hsa04713 |
| Dilated cardiomyopathy | hsa05414 |
| Endocrine and other factor-regulated calcium reabsorption | hsa04961 |
| Estrogen signaling pathway | hsa04915 |
| GABAergic synapse | hsa04727 |
| Gap junction | hsa04540 |
| Gastric acid secretion | hsa04971 |
| Glutamatergic synapse | hsa04724 |
| GnRH signaling pathway | hsa04912 |
| HTLV-I infection | hsa05166 |
| Inflammatory mediator regulation of TRP channels | hsa04750 |
| Insulin secretion | hsa04911 |
| Longevity regulating pathway - mammal | hsa04211 |
| Longevity regulating pathway - multiple species | hsa04213 |
| Melanogenesis | hsa04916 |
| Morphine addiction | hsa05032 |
| Oocyte meiosis | hsa04114 |
| Ovarian steroidogenesis | hsa04913 |
| Oxytocin signaling pathway | hsa04921 |
| Pancreatic secretion | hsa04972 |
| Pathways in cancer | hsa05200 |
| Phospholipase D signaling pathway | hsa04072 |
| Platelet activation | hsa04611 |
| Progesterone-mediated oocyte maturation | hsa04914 |
| Purine metabolism | hsa00230 |
| Rap1 signaling pathway | hsa04015 |
| Regulation of lipolysis in adipocytes | hsa04923 |
| Retrograde endocannabinoid signaling | hsa04723 |
| Salivary secretion | hsa04970 |
| Thyroid hormone synthesis | hsa04918 |
| Vascular smooth muscle contraction | hsa04270 |
| Vasopressin-regulated water reabsorption | hsa04962 |
| Vibrio cholerae infection | hsa05110 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd07302 | 392-571 | CHD |
| cl11967 | 392-571 | Nucleotidyl_cyc_III superfamily |
| cd07302 | 1059-1241 | CHD |
| cl11967 | 1059-1241 | Nucleotidyl_cyc_III superfamily |
| pfam00211 | 387-573 | Guanylate_cyc |
| pfam00211 | 1050-1241 | Guanylate_cyc |
| cd07556 | 392-530 | Nucleotidyl_cyc_III |
| cd07556 | 1058-1207 | Nucleotidyl_cyc_III |
| smart00044 | 326-544 | CYCc |
| smart00044 | 1024-1224 | CYCc |
| COG2114 | 386-542 | AcyC |
| COG2114 | 1025-1237 | AcyC |
Ontology Information
| HPRD ID | 2995 |
|---|---|
| Molecular Class | Adenylate cyclase |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.