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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25640382 | 2015 | Cell line : - Source : Uludag University Hospital. Sample Type : CRC tumor and adjacent normal tissue No. of Sample : 50 CRC and 82 patients diagnosed with adenomatous polyps Stage : - | immunohistochemistry | Down-regulation | - | Expression of both adipo-R1 and adipo-R2 was found to be significantly lower in the CRCs than in colorectal adenomas. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Unclassified : Adiponectin receptors |
| Description | The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008] | Chromosome | 12 |
| Location | 12p13 |
| Start | 1800147 |
| End | 1897845 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 97699 |
| OMIM ID | 607946 |
| HGNC ID | HGNC:24041 |
| Unigene ID | Hs.371642 |
| Ensembl ID | ENSG00000006831 |
| PharmGKB ID | PA128394711 |
Protein Information
| Protein ID | NP_078827.2 |
|---|---|
| Protein Name | adiponectin receptor 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 386 |
| Uniprot ID | Q969F8 |
| Ensembl Protein ID | ENSP00000234371 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 9370 | ADIPOQ | 5671 | NP_004788.1 | in vivo | 12802337 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adipocytokine signaling pathway | hsa04920 |
| AMPK signaling pathway | hsa04152 |
| Longevity regulating pathway - mammal | hsa04211 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03006 | 140-363 | HlyIII |
| cl03831 | 140-363 | HlyIII superfamily |
| COG1272 | 116-366 | YqfA |
| TIGR01065 | 145-363 | hlyIII |
| PRK05771 | 156-327 | PRK05771 |
Ontology Information
| HPRD ID | 9529 |
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | Motor activity (GO:0003774) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.