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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ADRM1 | 11047 | adhesion regulating molecule 1 | 20 | GP110, Rpn13, ARM1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18829976 | 2009 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 34 non-progressed colorectal adenomas, 41 progressed adenomas, and 33 adenocarcinomas tissue sample Stage : - | CGH (comparative genomic hybridisation) assay,microarray ,immunohistochemistry, tissue microarrays | Up-regulation | - | C20orf24, AURKA, RNPC1, TH1L, ADRM1, C20orf20 and TCFL5 genes to be important in chromosomal instability-related adenoma to carcinoma progression. |
| 20137344 | 2009 | Cell line : RKO Source : - Sample Type : - No. of Sample : - Stage : - | Western blotting,soft agar assay,MTT, and TUNEL assay, flow cytometry | Up-regulation | - | Adrm1 RNA interference and chemotherapy may become as a novel therapeutic strategy for Adrm1 overexpressed colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] | Chromosome | 20 |
| Location | 20q13.33 |
| Start | 60877112 |
| End | 60884206 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7095 |
| OMIM ID | 610650 |
| HGNC ID | HGNC:15759 |
| Unigene ID | Hs.90107 |
| Ensembl ID | ENSG00000130706 |
| PharmGKB ID | PA24599 |
Protein Information
| Protein ID | NP_001268366.1 |
|---|---|
| Protein Name | adhesion regulating molecule 1 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 407 |
| Uniprot ID | Q9H2X6 |
| Ensembl Protein ID | ENSP00000385571 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 405;- |
| S | Phosphorylation | 405;- |
| S | Phosphorylation | 211 |
| S | Phosphorylation | 211 |
| S | Phosphorylation | 213 |
| T | Phosphorylation | 217 |
| S | Phosphorylation | 213 |
| T | Phosphorylation | 217 |
| S | Phosphorylation | 220 |
| S | Phosphorylation | 220 |
| T | Phosphorylation | 222 |
| T | Phosphorylation | 222 |
| T | Acetylation | 2 |
| T | Acetylation | 2 |
| K | Acetylation | 21 |
| K | Acetylation | 21 |
| T | Phosphorylation | 2 |
| T | Phosphorylation | 3 |
| S | Phosphorylation | 15 |
| T | Phosphorylation | 2 |
| T | Phosphorylation | 3 |
| S | Phosphorylation | 15 |
| S | Phosphorylation | 4 |
| S | Phosphorylation | 10 |
| S | Phosphorylation | 4 |
| S | Phosphorylation | 10 |
| T | Phosphorylation | 39 |
| T | Phosphorylation | 39 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5707 | PSMD1 | 10169 | NP_002798.2 | in vitro;in vivo;yeast 2-hybrid | 1 650 155 916 990 800 000 000 000 000 000 000 000 000 |
| 5710 | PSMD4 | 3386 | NP_002801.1 | in vivo | 16990800 |
| 5886 | RAD23A | 7191 | NP_005044.1 | in vitro | 18497817 |
| 5887 | RAD23B | 6772 | NP_002865.1 | in vitro | 18497817 |
| 6184 | RPN1 | 1598 | NP_002941.1 | in vitro | 16990800 |
| 6185 | RPN2 | 1609 | NP_002942.2 | in vitro | 16990800 |
| 10213 | PSMD14 | 6208 | NP_005796.1 | in vivo | 17139257 |
| 29978 | UBQLN2 | 2224 | NP_038472.2 | in vitro | 18497817 |
| 29979 | UBQLN1 | 5440 | NP_038466.2 | yeast 2-hybrid | 16713569 |
| 51377 | UCHL5 | 10293 | NP_057068.1 | in vitro;in vivo;yeast 2-hybrid | 16 501 559 171 392 500 000 000 000 000 000 |
| 414301 | DDI1 | 13128 | NP_001001711.1 | in vitro | 18497817 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd13314 | 24-128 | PH_Rpn13 |
| cl17171 | 24-128 | PH-like superfamily |
| pfam04683 | 29-112 | Proteasom_Rpn13 |
| cd00900 | 24-124 | PH-like |
Ontology Information
| HPRD ID | 10196 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Ribonuclease activity (GO:0004540) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.