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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| AGTR1 | 185 | angiotensin II receptor, type 1 | 3 | AT1, AT2R1, AGTR1A, AT2R1A, HAT1R, AG2S, AT2R1B, AT1B |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23694962 | 2013 | Cell line : - Source : University Hospital of Bellvitge, Barcelona, Spain. Sample Type : CRC Tumor and adjecent normal tissue No. of Sample : 92 Stage : - | Microarray, DNA methylation assay, Pyrosequencing | Methylation | - | Methylation markers can be useful for early diagnosis of CRC using stool DNA. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Angiotensin receptors |
| Description | Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012] | Chromosome | 3 |
| Location | 3q24 |
| Start | 148415658 |
| End | 148460790 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 45133 |
| OMIM ID | 106165 |
| HGNC ID | HGNC:336 |
| Unigene ID | Hs.477887 |
| Ensembl ID | ENSG00000144891 |
| PharmGKB ID | PA43 |
mRNA Information
| mRNA ID | NM_031850.3 |
|---|---|
| Exon | join(1..257,10074..10157,32310..32367,43119..45133) | mRNA Sequence | Download Select all |
| Length | 2426 |
Protein Information
| Protein ID | NP_114038.4 |
|---|---|
| Protein Name | angiotensin II receptor, type 1 |
| Molecular Wt. (Da) | 44788 |
| Protein Sequence | Download Select all |
| Length | 394 |
| Uniprot ID | P61326 |
| Ensembl Protein ID | ENSP00000360521 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 302 |
| Y | Phosphorylation | 319 |
| Y | Phosphorylation | 302 |
| Y | Phosphorylation | 319 |
| Y | Phosphorylation | 302 |
| Y | Phosphorylation | 319 |
| Y | Phosphorylation | 302 |
| Y | Phosphorylation | 319 |
| Y | Phosphorylation | 302 |
| Y | Phosphorylation | 319 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 156 | ADRBK1 | 182 | NP_001610.2 | in vivo | 8662816 |
| 157 | ADRBK2 | 183 | NP_005151.2 | in vivo | 8662816 |
| 408 | ARRB1 | 146 | NP_004032.2 | in vivo | 11579203 |
| 1956 | EGFR | 579 | NP_005219.2 | in vitro | 12522132 |
| 2869 | GRK5 | 2926 | NP_005299.1 | in vivo | 8662816 |
| 5894 | RAF1 | 1265 | NP_002871.1 | in vitro;in vivo | 8753867 |
| 7064 | THOP1 | 3072 | NP_003240.1 | in vitro;yeast 2-hybrid | 15376229 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Adrenergic signaling in cardiomyocytes | hsa04261 |
| AGE-RAGE signaling pathway in diabetic complications | hsa04933 |
| Aldosterone synthesis and secretion | hsa04925 |
| Calcium signaling pathway | hsa04020 |
| cGMP-PKG signaling pathway | hsa04022 |
| Neuroactive ligand-receptor interaction | hsa04080 |
| Pathways in cancer | hsa05200 |
| Phospholipase D signaling pathway | hsa04072 |
| Renin secretion | hsa04924 |
| Renin-angiotensin system | hsa04614 |
| Vascular smooth muscle contraction | hsa04270 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam10328 | 37-156 | 7TM_GPCR_Srx |
| cl21561 | 37-156 | 7tm_4 superfamily |
| pfam05296 | 26-224 | TAS2R |
| cl18460 | 26-224 | TAS2R superfamily |
| pfam00001 | 51-302 | 7tm_1 |
| PHA03087 | 16-318 | PHA03087 |
| PHA02638 | 31-339 | PHA02638 |
| PHA02834 | 22-313 | PHA02834 |
| PHA03235 | 8-353 | PHA03235 |
Ontology Information
| HPRD ID | 1142 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Structural molecule activity (GO:0005198) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P30556 | DB00177 | Valsartan | SmallMoleculeDrug |
| P30556 | DB00275 | Olmesartan | SmallMoleculeDrug |
| P30556 | DB00678 | Losartan | SmallMoleculeDrug |
| P30556 | DB00796 | Candesartan | SmallMoleculeDrug |
| P30556 | DB00876 | Eprosartan | SmallMoleculeDrug |
| P30556 | DB00966 | Telmisartan | SmallMoleculeDrug |
| P30556 | DB01029 | Irbesartan | SmallMoleculeDrug |
| P30556 | DB01342 | Forasartan | SmallMoleculeDrug |
| P30556 | DB01347 | Saprisartan | SmallMoleculeDrug |
| P30556 | DB01349 | Tasosartan | SmallMoleculeDrug |
| P30556 | DB08822 | Azilsartan medoxomil | SmallMoleculeDrug |