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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
AIFM1 9131 Apoptosis-inducing factor, mitochondrion-associated, 1  XAIF; CMTX4; COWCK; PDCD8; COXPD6 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
20089989   2010Cell line : -

Source : VU University Medical Center, Amsterdam, The Netherlands.

Sample Type : CRC tumor

No. of Sample : -

Stage : -

Biochemical isolation to nano-LC-MS/MS analysisUp-regulation-This genes are differenitially expressed between colorectal adenoma and Colorectal cancer tissue.


Gene Details



Chromosome: X; NC_000023.10 (129263337..129299861, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, May 2010]  
Chromosome X
Location Xq26.1
Start 130129362  
End 130165887  
Strand +  
Gene Sequence

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Length 36526  
OMIM ID 300169   
HGNC ID HGNC:8768   
Unigene ID Hs.424932    
Ensembl ID ENSG00000156709   
PharmGKB ID -   

mRNA Information


mRNA ID NM_145813.2
Exon join(1..337,28703..28810,29157..29245,29703..29843, 32433..32575,34089..34213,35722..35918,36260..36526)  
mRNA Sequence

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Length 1428  



CDS Information


   
Locationjoin(232..337,28703..28810,29157..29245,29703..29843, 32433..32575,34089..34213,35722..35918,36260..36331) 50384..50528,51802..51902,52265..52429)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_001124318.1
Protein NameApoptosis-inducing factor, mitochondrion-associated, 1
Molecular Wt. (Da)28273
Protein Sequence

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Length 261  
Uniprot IDQ13541
Ensembl Protein ID ENSP00000340691  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation268
SPhosphorylation264
TPhosphorylation105
TPhosphorylation101
KAcetylation295
KAcetylation291
TPhosphorylation328
TPhosphorylation324
TPhosphorylation41

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
836CASP32799NP_004337.2in vitro9206994   
3303HSPA1A774NP_005336.3in vitro;in vivo1   153   366   412   930   700   
8666EIF3G4886NP_003746.2in vitro;yeast 2-hybrid17094969   
9869SETDB16828NP_001138887.1yeast 2-hybrid16169070   
23286WWC110033NP_056053.1yeast 2-hybrid16169070   
81628TSC22D418231NP_112197.1yeast 2-hybrid16713569   
84273C4orf1412823NP_115689.1yeast 2-hybrid16169070   


Pathway Information


      
Pathway Name Pathway ID
Apoptosis hsa04210


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam14721465-595  AIF_C
cl20654465-595  AIF_C superfamily
pfam149621-123  AIF-MLS
cl208431-123  AIF-MLS superfamily
pfam00070302-386  Pyr_redox
cl21454302-386  NADB_Rossmann superfamily
pfam07992150-444  Pyr_redox_2
COG0446143-487  FadH2
PRK09754149-485  PRK09754
COG1251149-443  NirB
COG1249224-441  Lpd
PRK09564224-476  PRK09564
TIGR02374150-440  nitri_red_nirB
COG1252222-468  Ndh
PRK04965225-440  PRK04965
TIGR03385220-471  CoA_CoA_reduc
TIGR01350223-439  lipoamide_DH
PRK06116221-438  PRK06116
PRK14989221-440  PRK14989
TIGR02053220-473  MerA
TIGR03169232-440  Nterm_to_SelD
PRK06370224-438  PRK06370
PRK05976243-438  PRK05976
PRK06292224-476  PRK06292
PRK06912225-440  acoL
PRK05249243-474  PRK05249
PRK07818243-438  PRK07818
PRK06416224-440  PRK06416
TIGR01424220-439  gluta_reduc_2
PTZ00058238-439  PTZ00058
TIGR01421238-438  gluta_reduc_1
TIGR03452247-468  mycothione_red
PRK07845224-438  PRK07845
PRK07846247-469  PRK07846
PRK14694221-438  PRK14694
PRK14727242-471  PRK14727
PRK13512205-440  PRK13512
PLN02546220-438  PLN02546
PRK06327243-438  PRK06327
COG0492218-447  TrxB
PLN02507222-439  PLN02507
PTZ00318251-440  PTZ00318
TIGR01316253-439  gltA


Ontology Information


   
HPRD ID556
Molecular ClassEnzyme: Oxidoreductase
Molecular FunctionExtracellular matrix structural constituent (GO:0005201)
Biological ProcessCell growth and/or maintenance (GO:0008151)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
O95831DB03147Flavin adenine dinucleotideSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO