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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| AKR1C1 | 1645 | aldo-keto reductase family 1, member C1 | 10 | DDH, MBAB, DD1, HAKRC |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23165153 | 2013 | Cell line : HeLa, HCT15, HT29,MCF7 Source : ATCC Sample Type : - No. of Sample : - Stage : - | RT-PCR analyses,Cell culture and transfection,Western blot and dot blot analyses. | Up-regulation | - | Involvement of up-regulated AKR1C1, AKR1C3 and proteasome in CDDP resistance of colon cancers and support a chemotherapeutic role for their inhibitors. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Aldo-keto reductases |
| Description | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008] | Chromosome | 10 |
| Location | 10p15-p14 |
| Start | 5005454 |
| End | 5020158 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 14705 |
| OMIM ID | 600449 |
| HGNC ID | HGNC:384 |
| Unigene ID | Hs.460260 |
| Ensembl ID | ENSG00000187134 |
| PharmGKB ID | PA24677 |
mRNA Information
| mRNA ID | NM_001353.5 |
|---|---|
| Exon | join(1..267,2653..2820,3666..3782,5048..5125,5561..5683, 8940..9049,9323..9488,12590..12672,14439..14705) | mRNA Sequence | Download Select all |
| Length | 1384 |
Protein Information
| Protein ID | NP_001344.2 |
|---|---|
| Protein Name | aldo-keto reductase family 1, member C1 |
| Molecular Wt. (Da) | 36657 |
| Protein Sequence | Download Select all |
| Length | 323 |
| Uniprot ID | Q13563 |
| Ensembl Protein ID | ENSP00000237596 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06660 | 8-299 | Aldo_ket_red |
| cl00470 | 8-299 | Aldo_ket_red superfamily |
| COG0656 | 8-305 | ARA1 |
| pfam00248 | 19-301 | Aldo_ket_red |
| PRK11565 | 8-304 | dkgA |
| PRK11172 | 16-312 | dkgB |
| COG4989 | 33-220 | YdhF |
| PRK10625 | 18-167 | tas |
| PLN02587 | 18-281 | PLN02587 |
| PRK09912 | 41-297 | PRK09912 |
| COG0667 | 17-297 | Tas |
| COG1453 | 13-296 | COG1453 |
| TIGR01293 | 19-201 | Kv_beta |
Ontology Information
| HPRD ID | 1529 |
|---|---|
| Molecular Class | Enzyme: Reductase |
| Molecular Function | Kinase activity (GO:0016301) |
| Biological Process | Energy pathways (GO:0006091); Metabolism (GO:0008152) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q04828 | DB00936 | Salicylic acid | SmallMoleculeDrug |
| Q04828 | DB00945 | Acetylsalicylic acid | SmallMoleculeDrug |