Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| AKR1C3 | 8644 | aldo-keto reductase family 1, member C3 | 10 | KIAA0119, DDX, HAKRB, PGFS |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24934327 | 2015 | Cell line : SW480 LN metastatic variant, SW620 Source : - Sample Type : CRC tumor No. of Sample : 27 tissue specimens (14 tumor specimens and 13 non-tumor specimens) and 125 LNs Stage : Duke Stage A-C | real time RT-PCR,Microarray | Up-regulation | - | AKR1C3 and CNN3 expressions are more accurate and suitable markers for the diagnosis of LN metastasis than the other six genes examined in this study. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Aldo-keto reductases |
| Description | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] | Chromosome | 10 |
| Location | 10p15-p14 |
| Start | 5090958 |
| End | 5149878 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 58921 |
| OMIM ID | 603966 |
| HGNC ID | HGNC:386 |
| Unigene ID | Hs.78183 |
| Ensembl ID | ENSG00000196139 |
| PharmGKB ID | PA24679 |
mRNA Information
| mRNA ID | ?NM_001253908.1 |
|---|---|
| Exon | join(1..130,47645..47812,48669..48785,50037..50114, 50562..50684,53336..53445,53720..53885,56830..56912, 58696..58921) | mRNA Sequence | Download Select all |
| Length | 1228 |
Protein Information
| Protein ID | NP_001240837.1 |
|---|---|
| Protein Name | aldo-keto reductase family 1, member C3 |
| Molecular Wt. (Da) | 99262 |
| Protein Sequence | Download Select all |
| Length | 323 |
| Uniprot ID | Q9H0E9 |
| Ensembl Protein ID | ENSP00000230901 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 209 |
| K | Acetylation | 246 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 11244 | ZHX1 | 10379 | NP_009153.3 | yeast 2-hybrid | 16169070 |
| 22985 | ACIN1 | 5191 | NP_055792.1 | yeast 2-hybrid | 16169070 |
| 55284 | UBE2W | 7724 | NP_001001481.1 | yeast 2-hybrid | 16169070 |
| 55791 | C1orf103 | 17975 | NP_060842.3 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Arachidonic acid metabolism | hsa00590 |
| Metabolic pathways | hsa01100 |
| Ovarian steroidogenesis | hsa04913 |
| Steroid hormone biosynthesis | hsa00140 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd06660 | 8-299 | Aldo_ket_red |
| cl00470 | 8-299 | Aldo_ket_red superfamily |
| COG0656 | 8-305 | ARA1 |
| pfam00248 | 19-301 | Aldo_ket_red |
| PRK11565 | 8-300 | dkgA |
| PRK11172 | 16-312 | dkgB |
| COG4989 | 34-220 | YdhF |
| PRK10625 | 18-305 | tas |
| PRK09912 | 21-297 | PRK09912 |
| PLN02587 | 18-281 | PLN02587 |
| COG0667 | 17-297 | Tas |
| COG1453 | 13-296 | COG1453 |
| TIGR01293 | 19-201 | Kv_beta |
Ontology Information
| HPRD ID | 9462 |
|---|---|
| Molecular Class | Enzyme: Reductase |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P42330 | DB00997 | Doxorubicin | SmallMoleculeDrug |
| P42330 | DB00905 | Bimatoprost | SmallMoleculeDrug |