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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ALCAM | 214 | activated leukocyte cell adhesion molecule | 3 | CD166, MEMD |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22482754 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : 299 Stage : - | Immunohistochemistry, tissue microarray,Multivariate analysis | Down-regulation | - | Elevated expression in higher differentiated tumors might indicate a potential role in the early steps of tumorigenesis, and its loss might be associated with reduced cellular adhesion, resulting in a higher metastatic potential of the tumor. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Immunoglobulin superfamily / V-set domain containing", "Immunoglobulin superfamily / C2-set domain containing", "Immunoglobulin superfamily / Immunoglobulin-like domain containing" |
| Description | This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011] | Chromosome | 3 |
| Location | 3q13.1 |
| Start | 105085557 |
| End | 105295757 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 210201 |
| OMIM ID | 601662 |
| HGNC ID | HGNC:400 |
| Unigene ID | Hs.591293 |
| Ensembl ID | ENSG00000170017 |
| PharmGKB ID | PA24691 |
mRNA Information
| mRNA ID | NM_001627.3 |
|---|---|
| Exon | join(1..769,153355..153455,157577..157796,165290..165354, 166891..166978,167951..168133,173263..173390, 174921..175053,178511..178623,180437..180572, 180678..180811,183415..183547,185432..185470, 185756..185873,205140..205252,207765..210201) | mRNA Sequence | Download Select all |
| Length | 4923 |
Protein Information
| Protein ID | NP_001618.2 |
|---|---|
| Protein Name | activated leukocyte cell adhesion molecule |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 583 |
| Uniprot ID | Q9UIS9 |
| Ensembl Protein ID | ENSP00000269468 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 167 |
| N | Glycosylation | 480 |
| N | Glycosylation | 499 |
| N | Glycosylation | 95 |
| N | Glycosylation | 361 |
| N | Glycosylation | 496 |
| N | Glycosylation | 265 |
| N | Glycosylation | 457 |
| N | Glycosylation | 466 |
| N | Glycosylation | 518 |
| N | Glycosylation | 360 |
| N | Glycosylation | 264 |
| N | Glycosylation | 456 |
| N | Glycosylation | 465 |
| N | Glycosylation | 495 |
| N | Glycosylation | 498 |
| N | Glycosylation | 517 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell adhesion molecules (CAMs) | hsa04514 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam08205 | 137-231 | C2-set_2 |
| cl11960 | 137-231 | Ig superfamily |
| smart00406 | 38-113 | IGv |
| cl11960 | 38-113 | Ig superfamily |
| cd07705 | 157-224 | Ig2_Necl-1 |
| cd07698 | 415-488 | IgC_MHC_I_alpha3 |
| cl11960 | 415-488 | Ig superfamily |
| cd05769 | 125-249 | IgC_TCR_beta |
| pfam13895 | 260-330 | Ig_2 |
| cl11960 | 260-330 | Ig superfamily |
| cd05761 | 157-222 | Ig2_Necl-1-4_like |
| cd05726 | 263-351 | Ig4_Robo |
| pfam13927 | 415-489 | Ig_3 |
| cd04972 | 432-500 | Ig_TrkABC_d4 |
| cd05759 | 157-232 | Ig2_KIRREL3-like |
| pfam13895 | 415-489 | Ig_2 |
| cd00096 | 432-499 | Ig |
| cd00098 | 157-226 | IgC |
| pfam13927 | 250-313 | Ig_3 |
| cd05881 | 36-118 | Ig1_Necl-2 |
| pfam13895 | 334-412 | Ig_2 |
| cl11960 | 334-412 | Ig superfamily |
| cd05736 | 432-500 | Ig2_Follistatin_like |
| cd05846 | 36-122 | Ig1_MRC-OX-2_like |
| cd05718 | 84-117 | Ig1_PVR_like |
| smart00410 | 255-329 | IG_like |
| smart00409 | 255-329 | IG |
| smart00410 | 339-393 | IG_like |
| smart00409 | 339-393 | IG |
| smart00408 | 346-393 | IGc2 |
| pfam07679 | 342-392 | I-set |
| smart00410 | 36-130 | IG_like |
| smart00409 | 36-130 | IG |
Ontology Information
| HPRD ID | 1107 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.