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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ALDH1B1 219 aldehyde dehydrogenase 1 family, member B1  9ALDHX 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21216231   2011Cell line : -

Source : IHCtech (Aurora, CO).

Sample Type : Formalin-fixed and paraffin-embedded tissues

No. of Sample : -

Stage : -

ImmunohistochemistryUp-regulation-This study relative to ALDH1A1 and that ALDH1B1 is dramatically upregulated in human colonic adenocarcinoma, making it a potential biomarker for human colon cancer.


Gene Details



NC_000009.11 (38392661..38398662)

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Gene Type protein coding
Gene Family Aldehyde dehydrogenases
Description This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems. [provided by RefSeq, Jul 2008]  
Chromosome 9
Location 9p13
Start 38392661  
End 38398662  
Strand +  
Gene Sequence

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Length 6002  
OMIM ID 100670   
HGNC ID HGNC:407   
Unigene ID Hs.436219   
Ensembl ID ENSG00000137124   
PharmGKB ID PA24695   

mRNA Information


mRNA ID NM_000692.4
Exon join(1..144,3077..6002)  
mRNA Sequence

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Length 3088  



CDS Information


   
Location154..1707
CDS Sequence

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CCDS ID CCDS6615.1



Protein Information


      
Protein IDNP_000683.3
Protein Namealdehyde dehydrogenase 1 family, member B1
Molecular Wt. (Da)0
Protein Sequence

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Length 517  
Uniprot IDQ01726
Ensembl Protein ID ENSP00000451605  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                                                                              
Pathway Name Pathway ID
Arginine and proline metabolism hsa00330
Ascorbate and aldarate metabolism hsa00053
beta-Alanine metabolism hsa00410
Fatty acid degradation hsa00071
Glycerolipid metabolism hsa00561
Glycolysis / Gluconeogenesis hsa00010
Histidine metabolism hsa00340
Lysine degradation hsa00310
Metabolic pathways hsa01100
Pentose and glucuronate interconversions hsa00040
Pyruvate metabolism hsa00620
Tryptophan metabolism hsa00380
Valine, leucine and isoleucine degradation hsa00280


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0714131-511  ALDH_F1AB_F2_RALDH1
cl1196131-511  ALDH-SF superfamily
cd0709137-510  ALDH_F1-2_Ald2-like
cd0714234-508  ALDH_F2BC
cd0714436-510  ALDH_ALD2-YMR170C
pfam0017145-508  Aldedh
cd0714339-512  ALDH_AldA_AN0554
PLN0276627-513  PLN02766
cd0711940-510  ALDH_BADH-GbsA
cd0711456-510  ALDH_DhaS
cd0711252-510  ALDH_GABALDH-PuuC
cd0707877-510  ALDH
cd0711556-512  ALDH_HMSADH_HapE
COG101237-513  AdhE
cd0709356-510  ALDH_F8_HMSADH
cd0755938-510  ALDH_ACDHII_AcoD-like
cd0714034-511  ALDH_F1L_FTFDH
cd0710957-510  ALDH_AAS00426
cd0711738-510  ALDH_StaphAldA1
cd0709056-508  ALDH_F9_TMBADH
cd0710357-510  ALDH_F5_SSADH_GabD
cd0713839-509  ALDH_CddD_SSP0762
PRK1325232-508  PRK13252
cd0711056-509  ALDH_F10_BADH
TIGR0180440-506  BADH
cd0711859-510  ALDH_SNDH
PLN0246732-509  PLN02467
cd0713939-510  ALDH_AldA-Rv0768
cd0713140-510  ALDH_AldH-CAJ73105
cd0709257-510  ALDH_ABALDH-YdcW
cd0709740-508  ALDH_KGSADH-YcbD
cd0708957-508  ALDH_CddD-AldA-like
cd0710657-510  ALDH_AldA-AAD23400
cd0653481-510  ALDH-SF
cd0711139-502  ALDH_F16
TIGR0229939-514  HpaE
PRK1347338-511  PRK13473
cd0710856-510  ALDH_MGR_2402
cd0710756-510  ALDH_PhdK-like
cd0711339-511  ALDH_PADH_NahF
cd0708840-510  ALDH_LactADH-AldA
cd0708640-510  ALDH_F7_AASADH-like
PRK0984737-510  PRK09847
cd0711640-510  ALDH_ACDHII-AcoD
cd0714954-510  ALDH_y4uC
PLN0227838-508  PLN02278
cd0712439-509  ALDH_PutA-P5CDH-RocA
cd0714554-510  ALDH_LactADH_F420-Bios
cd0715054-510  ALDH_VaniDH_like
cd0710475-510  ALDH_BenzADH-like
TIGR0321640-512  OH_muco_semi_DH
cd0712056-509  ALDH_PsfA-ACA09737
TIGR0178057-506  SSADH
cd0709457-510  ALDH_F21_LactADH-like
cd0710076-510  ALDH_SSADH1_GabD1
cd0708538-509  ALDH_F6_MMSDH
cd0709957-510  ALDH_DDALDH
PRK0313739-509  PRK03137
cd0715143-511  ALDH_HBenzADH
TIGR0337437-511  ABALDH
cd0714657-510  ALDH_PhpJ
cd0708240-511  ALDH_F11_NP-GAPDH
PRK0940747-509  gabD2
cd0710159-509  ALDH_SSADH2_GabD2
cd0714754-510  ALDH_F21_RNP123
cd0710575-510  ALDH_SaliADH
PRK1124138-512  gabD
cd0715262-510  ALDH_BenzADH
cd0710257-508  ALDH_EDX86601
TIGR0123739-509  D1pyr5carbox2
TIGR0428438-508  aldehy_Rv0768
PRK10090148-511  PRK10090
cd0709857-509  ALDH_F15-22
cd0713042-510  ALDH_F7_AASADH
PRK0940656-510  gabD1
TIGR0325046-510  PhnAcAld_DH
cd0708339-509  ALDH_P5CDH
cd0712527-515  ALDH_PutA-P5CDH
cd0709575-492  ALDH_SGSD_AstD
cd0714857-491  ALDH_RL0313
TIGR0172238-509  MMSDH
PRK1396856-508  PRK13968
cd0713493-508  ALDH_AlkH-like
cd0708779-510  ALDH_F3-13-14_CALDH-like
PLN0041227-513  PLN00412
TIGR0324039-492  arg_catab_astD
PRK0945739-492  astD
PLN0231540-510  PLN02315
TIGR0123855-495  D1pyr5carbox3
cd07136125-508  ALDH_YwdH-P39616
cd0713574-508  ALDH_F14-YMR110C
cd07133172-508  ALDH_CALDH_CalB
TIGR0123650-489  D1pyr5carbox1
cd0712362-489  ALDH_F4-17_P5CDH
PTZ0038174-511  PTZ00381
cd0713279-511  ALDH_F3AB
cd0713776-508  ALDH_F3FHI
PLN0220384-509  PLN02203
cd0708476-452  ALDH_KGSADH-like
PRK1190340-501  PRK11903
cd0712838-501  ALDH_MaoC-N
PLN02174174-508  PLN02174
cd0712640-473  ALDH_F12_P5CDH
cd0712976-319  ALDH_KGSADH
cd07077101-472  ALDH-like
cd0708176-472  ALDH_F20_ACDH_EutE-like
cd0712772-327  ALDH_PAD-PaaZ
TIGR02288179-327  PaaN_2
TIGR0251878-374  EutH_ACDH
cd0712174-338  ALDH_EutE
PLN024666-516  PLN02466
COG423052-495  PutA2
PLN024192-509  PLN02419
PRK1190440-510  PRK11904
PRK1190546-491  PRK11905
PRK1180955-491  putA
TIGR0227838-501  PaaN-DH
PRK1156338-456  PRK11563


Ontology Information


   
HPRD ID1120
Molecular ClassEnzyme: Dehydrogenase
Molecular FunctionCell adhesion molecule activity (GO:0005194)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO