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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ALDH2 217 aldehyde dehydrogenase 2 family (mitochondrial)  12- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25450519   2014Cell line : -

Source : Northern Israel population

Sample Type : Population based case-control study

No. of Sample : 2100 matched pairs

Stage : -

SSCP, direct sequencing analysisFrameshift Mutation--

24282520   2013Cell line : -

Source : PubMed, Web of Science and CNKI

Sample Type : -

No. of Sample : -

Stage : -

-Polymorhpism-Genetic polymorphisms in the alcohol metabolism pathways have a potential role in colorectal carcinogenesis.

24334570   2013Cell line : -

Source : -

Sample Type : Population based case-control study

No. of Sample : 2909 cases and 4903 controls.

Stage : -

Meta analysisPolymorhpism- ALDH2 polymorphism, but not the ADH1B polymorphism, significantly increases the risk of CRC in East Asians.

24558407   2014Cell line : -

Source : Korean Descent

Sample Type : CRC and GC tumor

No. of Sample : 90 Sporadic Gastric carcinoma, 141 sporadic Colorectal carcinoma

Stage : -

 Meta analysisPolymorhpism- ALDH2 Glu487Lys polymorphism may be associated with a decreased risk of colorectal cancer.


Gene Details



NC_000012.11 (112204691..112247789)

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Gene Type protein coding
Gene Family Aldehyde dehydrogenases
Description This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]  
Chromosome 12
Location 12q24.12
Start 112204691  
End 112247789  
Strand +  
Gene Sequence

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Length 43099  
OMIM ID 100650   
HGNC ID HGNC:404   
Unigene ID Hs.604551   
Ensembl ID -   
PharmGKB ID PA24696   

mRNA Information


mRNA ID NM_000690.3
Exon join(1..210,15032..15136,16272..16412,18381..18460, 22937..23048,23548..23676,24420..24533,25175..25277, 25712..25896,31192..31356,33020..33177,36973..37087, 42657..43099)  
mRNA Sequence

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Length 2076  



CDS Information


   
Location97..1650
CDS Sequence

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CCDS ID CCDS55885.1



Protein Information


      
Protein IDNP_000681.2
Protein Namealdehyde dehydrogenase 2 family (mitochondrial)
Molecular Wt. (Da)0
Protein Sequence

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Length 517  
Uniprot IDP11226
Ensembl Protein ID ENSP00000363079  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation480

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                         
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1400CRMP13913NP_001014809.1yeast 2-hybrid16169070   
3692EIF64221NP_852133.1yeast 2-hybrid16169070   
9094UNC1194927NP_005139.1yeast 2-hybrid16169070   
11161C14orf15201NP_009107.1yeast 2-hybrid16169070   
54978C2orf1812808NP_060347.2yeast 2-hybrid16169070   
55855FAM45B6592NP_060942.2yeast 2-hybrid16169070   
84966IGSF2111309NP_116269.2yeast 2-hybrid16169070   


Pathway Information


                                                                              
Pathway Name Pathway ID
Arginine and proline metabolism hsa00330
Ascorbate and aldarate metabolism hsa00053
beta-Alanine metabolism hsa00410
Fatty acid degradation hsa00071
Glycerolipid metabolism hsa00561
Glycolysis / Gluconeogenesis hsa00010
Histidine metabolism hsa00340
Lysine degradation hsa00310
Metabolic pathways hsa01100
Pentose and glucuronate interconversions hsa00040
Pyruvate metabolism hsa00620
Tryptophan metabolism hsa00380
Valine, leucine and isoleucine degradation hsa00280


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0714131-511  ALDH_F1AB_F2_RALDH1
cl1196131-511  ALDH-SF superfamily
cd0709134-510  ALDH_F1-2_Ald2-like
cd0714237-508  ALDH_F2BC
cd0714339-512  ALDH_AldA_AN0554
cd0714439-510  ALDH_ALD2-YMR170C
pfam0017145-508  Aldedh
PLN0276632-513  PLN02766
cd0711940-508  ALDH_BADH-GbsA
cd0707877-510  ALDH
cd0711252-508  ALDH_GABALDH-PuuC
cd0711556-512  ALDH_HMSADH_HapE
cd0711456-510  ALDH_DhaS
COG101237-513  AdhE
cd0709356-510  ALDH_F8_HMSADH
cd0755938-510  ALDH_ACDHII_AcoD-like
cd0714037-511  ALDH_F1L_FTFDH
cd0709056-510  ALDH_F9_TMBADH
PRK1325238-510  PRK13252
TIGR0180440-506  BADH
cd0711738-510  ALDH_StaphAldA1
cd0710957-510  ALDH_AAS00426
cd0711056-509  ALDH_F10_BADH
cd0713839-509  ALDH_CddD_SSP0762
cd0711859-510  ALDH_SNDH
PLN0246724-509  PLN02467
cd0710357-510  ALDH_F5_SSADH_GabD
cd0653481-510  ALDH-SF
cd0711140-502  ALDH_F16
cd0708957-508  ALDH_CddD-AldA-like
cd0713939-510  ALDH_AldA-Rv0768
cd0709257-510  ALDH_ABALDH-YdcW
PRK1347338-511  PRK13473
cd0710657-510  ALDH_AldA-AAD23400
TIGR0229940-514  HpaE
cd0710856-510  ALDH_MGR_2402
cd0711640-510  ALDH_ACDHII-AcoD
cd0713140-510  ALDH_AldH-CAJ73105
cd0709740-508  ALDH_KGSADH-YcbD
cd0708840-508  ALDH_LactADH-AldA
PRK0984737-508  PRK09847
cd0710756-510  ALDH_PhdK-like
cd0711340-511  ALDH_PADH_NahF
cd0715054-510  ALDH_VaniDH_like
PLN0227818-508  PLN02278
cd0712439-512  ALDH_PutA-P5CDH-RocA
cd0710475-510  ALDH_BenzADH-like
cd0708640-510  ALDH_F7_AASADH-like
cd0714954-510  ALDH_y4uC
TIGR0321640-512  OH_muco_semi_DH
cd0714554-510  ALDH_LactADH_F420-Bios
cd0712056-510  ALDH_PsfA-ACA09737
cd0710076-510  ALDH_SSADH1_GabD1
TIGR0178057-506  SSADH
TIGR0337437-511  ABALDH
cd0715143-511  ALDH_HBenzADH
PRK0313741-509  PRK03137
cd0709957-510  ALDH_DDALDH
cd0709457-510  ALDH_F21_LactADH-like
cd0708538-511  ALDH_F6_MMSDH
PRK0940747-510  gabD2
cd0710159-510  ALDH_SSADH2_GabD2
cd0710257-508  ALDH_EDX86601
cd0708238-511  ALDH_F11_NP-GAPDH
TIGR0428453-508  aldehy_Rv0768
cd0714754-506  ALDH_F21_RNP123
cd0714657-510  ALDH_PhpJ
cd0710575-510  ALDH_SaliADH
cd0715262-510  ALDH_BenzADH
PRK1124132-506  gabD
TIGR0123756-509  D1pyr5carbox2
PRK10090105-508  PRK10090
PRK0940656-508  gabD1
cd0709857-510  ALDH_F15-22
cd0708339-509  ALDH_P5CDH
cd071258-515  ALDH_PutA-P5CDH
cd0713042-510  ALDH_F7_AASADH
TIGR0325058-510  PhnAcAld_DH
TIGR0172240-511  MMSDH
cd0713493-508  ALDH_AlkH-like
cd0714857-491  ALDH_RL0313
cd0708779-508  ALDH_F3-13-14_CALDH-like
PRK1396856-508  PRK13968
cd0709575-492  ALDH_SGSD_AstD
TIGR0123855-506  D1pyr5carbox3
cd0713574-508  ALDH_F14-YMR110C
TIGR0324040-492  arg_catab_astD
cd0713384-508  ALDH_CALDH_CalB
PRK0945740-492  astD
cd0713697-508  ALDH_YwdH-P39616
PLN0041220-513  PLN00412
cd0712357-490  ALDH_F4-17_P5CDH
TIGR0123650-490  D1pyr5carbox1
PLN0231540-510  PLN02315
PTZ0038172-511  PTZ00381
cd0713278-511  ALDH_F3AB
cd0713780-508  ALDH_F3FHI
PLN0220369-509  PLN02203
PRK1190340-501  PRK11903
cd0708476-495  ALDH_KGSADH-like
PLN02174117-508  PLN02174
cd0712838-501  ALDH_MaoC-N
cd0712976-421  ALDH_KGSADH
cd0712640-452  ALDH_F12_P5CDH
cd07077101-484  ALDH-like
TIGR02288150-351  PaaN_2
cd07127179-351  ALDH_PAD-PaaZ
cd07081164-471  ALDH_F20_ACDH_EutE-like
cd00532222-261  MGS-like
cl00245222-261  MGS-like superfamily
cd07080104-227  ALDH_Acyl-CoA-Red_LuxC
PLN024663-516  PLN02466
PRK1190455-510  PRK11904
COG423052-495  PutA2
PRK1190540-491  PRK11905
PLN0241917-509  PLN02419
PRK1180955-491  putA
TIGR0227838-501  PaaN-DH
PRK1156338-456  PRK11563


Ontology Information


   
HPRD ID1118
Molecular ClassEnzyme: Dehydrogenase
Molecular FunctionReceptor activity (GO:0004872)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P05091DB00435Nitric OxideSmallMoleculeDrug
P05091DB00727NitroglycerinSmallMoleculeDrug
P05091DB01612Amyl NitriteSmallMoleculeDrug
P05091DB06770Benzyl alcoholSmallMoleculeDrug
P05091DB00536GuanidineSmallMoleculeDrug
P05091DB00822DisulfiramSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO