Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ALK | 238 | anaplastic lymphoma receptor tyrosine kinase  | 2 | CD246  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24129244    | 2013 | Cell line : - Source : King Faisal Specialist Hospital and Research Centre (KFSHRC) and Security Forces Hospital, Riyadh. Sample Type : CRC tumor and normal tissue No. of Sample : 770 Stage : - | Fluorescence in situ hybridisation (FISH) and immunohistochemistry,Quantitative real-time PCR, PCR and DNA sequencing . | Amplification | - | - |
| 24691006    | 2014 | Cell line : - Source : Fondazione IRCCS Istituto Nazionale dei Tumori. Sample Type : CRC tumor and normal tissue No. of Sample : 68 Stage : TNM Stage IV | FISH | Amplification | - | Gain of ALK gene copy number might represent a negative prognostic factor in mCRC and may have a role in resistance to anti-EGFR therapy. |
| 25926053    | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Mutation | - | Genomic rearrangements (translocations) involving the ALK and NTRK1 genes are associated with the overexpression of the corresponding proteins in CRC specimens. |
| 26172300    | 2015 | Cell line : - Source : Samsung Medical Center, Seoul, Korea . Sample Type : CRC tumor and normal tissue No. of Sample : 432 GC and 172 CRC Stage : Stage I-IV | Tissue microarrays, Immunohystochemistry, FISH, NGS-based comprehensive genomic profiling, Immunoblotting. | Mutation | - | ALK rearrangement is a potential actionable driver mutation in CRC based on survival inhibition of patient tumor-derived cell line by potent ALK inhibitors. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules |
| Description | This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]   | Chromosome | 2 |
| Location | 2p23 |
| Start | 29415640   |
| End | 30144477   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 728838   |
| OMIM ID | 105590    |
| HGNC ID | HGNC:427    |
| Unigene ID | Hs.654469    |
| Ensembl ID | ENSG00000171094    |
| PharmGKB ID | PA24719    |
mRNA Information
| mRNA ID | NM_004304.4 |
|---|---|
| Exon | join(1..1619,203915..204034,226598..226762,389496..389697, 537753..537880,593131..593262,600730..600861, 603208..603308,624555..624724,646116..646210, 646385..646513,670345..670507,681782..681932, 687916..688047,689164..689308,692546..692728, 693940..694038,694538..694690,696047..696151, 698084..698270,699005..699095,699204..699268, 700777..700906,707531..707628,711734..711826, 714340..714441,723936..724070,724752..724842, 727690..728838)   | mRNA Sequence |    Download   Select all |
| Length | 6267   |
CDS Information
| Location | 953..5815 |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS33172.1 |    
Protein Information
| Protein ID | NP_004295.2 |
|---|---|
| Protein Name | anaplastic lymphoma receptor tyrosine kinase |
| Molecular Wt. (Da) | 0 |
| Protein Sequence |    Download   Select all |
| Length | 1620   |
| Uniprot ID | P43121 |    
| Ensembl Protein ID | ENSP00000264036   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 1282 |
| Y | Phosphorylation | 1283 |
| Y | Phosphorylation | 1604 |
| S | Phosphorylation | 211 |
| Y | Phosphorylation | 1078;- |
| Y | Phosphorylation | 1096;- |
| Y | Phosphorylation | 1278;- |
| Y | Phosphorylation | 1507;- |
| Y | Phosphorylation | 1584;- |
| Y | Phosphorylation | 1092;- |
| Y | Phosphorylation | 1078;- |
| Y | Phosphorylation | 1096;- |
| Y | Phosphorylation | 1278;- |
| Y | Phosphorylation | 1359;- |
| Y | Phosphorylation | 1507;- |
| S | Phosphorylation | 47 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5803 |    PTPRZ1 |    1481 |    NP_002842.2 |    in vitro;in vivo |    17681947    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Non-small cell lung cancer |    hsa05223 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05036 | 1109-1385  | PTKc_ALK_LTK |
| cl21453 | 1109-1385  | PKc_like superfamily |
| cd06263 | 480-631  | MAM |
| cl18943 | 480-631  | MAM superfamily |
| cd06263 | 266-424  | MAM |
| cl18943 | 266-424  | MAM superfamily |
| cd00192 | 1122-1384  | PTKc |
| cd05044 | 1122-1384  | PTKc_c-ros |
| cd05032 | 1110-1384  | PTKc_InsR_like |
| cd05049 | 1110-1383  | PTKc_Trk |
| cd05048 | 1110-1383  | PTKc_Ror |
| cd05061 | 1110-1384  | PTKc_InsR |
| cd05041 | 1122-1383  | PTKc_Fes_like |
| cd05053 | 1110-1384  | PTKc_FGFR |
| cd05062 | 1110-1384  | PTKc_IGF-1R |
| cd05050 | 1110-1382  | PTKc_Musk |
| cd05084 | 1122-1379  | PTKc_Fes |
| cd05059 | 1114-1383  | PTKc_Tec_like |
| cd05092 | 1111-1384  | PTKc_TrkA |
| cd05039 | 1110-1384  | PTKc_Csk_like |
| cd05051 | 1110-1376  | PTKc_DDR |
| cd05034 | 1120-1384  | PTKc_Src_like |
| cd05060 | 1122-1383  | PTKc_Syk_like |
| cd05068 | 1107-1384  | PTKc_Frk_like |
| cd05085 | 1122-1377  | PTKc_Fer |
| cd05033 | 1114-1384  | PTKc_EphR |
| cd05046 | 1111-1384  | PTK_CCK4 |
| cd05093 | 1111-1375  | PTKc_TrkB |
| cd05035 | 1116-1384  | PTKc_TAM |
| cd05099 | 1110-1403  | PTKc_FGFR4 |
| cd05148 | 1110-1383  | PTKc_Srm_Brk |
| cd05075 | 1116-1389  | PTKc_Axl |
| cd05055 | 1095-1384  | PTKc_PDGFR |
| cd05094 | 1111-1375  | PTKc_TrkC |
| cd05052 | 1110-1384  | PTKc_Abl |
| cd05074 | 1111-1384  | PTKc_Tyro3 |
| cd14204 | 1111-1384  | PTKc_Mer |
| cd05098 | 1110-1384  | PTKc_FGFR1 |
| cd05112 | 1116-1383  | PTKc_Itk |
| cd05090 | 1110-1383  | PTKc_Ror1 |
| cd05056 | 1110-1384  | PTKc_FAK |
| cd05100 | 1110-1403  | PTKc_FGFR3 |
| cd13999 | 1122-1383  | STKc_MAP3K-like |
| cd05045 | 1115-1384  | PTKc_RET |
| cd05113 | 1111-1384  | PTKc_Btk_Bmx |
| cd05083 | 1114-1384  | PTKc_Chk |
| cd05097 | 1110-1379  | PTKc_DDR_like |
| cd05101 | 1110-1384  | PTKc_FGFR2 |
| cd05114 | 1116-1385  | PTKc_Tec_Rlk |
| cd05058 | 1122-1384  | PTKc_Met_Ron |
| cd05040 | 1122-1381  | PTKc_Ack_like |
| cd05106 | 1095-1384  | PTKc_CSF-1R |
| cd05095 | 1110-1379  | PTKc_DDR2 |
| cd05067 | 1110-1376  | PTKc_Lck_Blk |
| cd05072 | 1110-1376  | PTKc_Lyn |
| cd05063 | 1110-1384  | PTKc_EphR_A2 |
| cd05054 | 1110-1383  | PTKc_VEGFR |
| cd05082 | 1113-1385  | PTKc_Csk |
| cd05057 | 1108-1390  | PTKc_EGFR_like |
| cd05091 | 1109-1383  | PTKc_Ror2 |
| cd05096 | 1110-1379  | PTKc_DDR1 |
| cd05102 | 1110-1381  | PTKc_VEGFR3 |
| cd05047 | 1122-1380  | PTKc_Tie |
| cd05066 | 1115-1380  | PTKc_EphR_A |
| cd05038 | 1111-1384  | PTKc_Jak_rpt2 |
| cd14203 | 1120-1376  | PTKc_Src_Fyn_like |
| cd05089 | 1114-1379  | PTKc_Tie1 |
| cd05104 | 1095-1384  | PTKc_Kit |
| cd14207 | 1110-1383  | PTKc_VEGFR1 |
| cd05065 | 1122-1384  | PTKc_EphR_B |
| cd05070 | 1107-1376  | PTKc_Fyn |
| cd05064 | 1110-1379  | PTKc_EphR_A10 |
| cd05105 | 1110-1384  | PTKc_PDGFR_alpha |
| cd05103 | 1110-1383  | PTKc_VEGFR2 |
| cd05069 | 1107-1384  | PTKc_Yes |
| cd05073 | 1107-1384  | PTKc_Hck |
| cd05043 | 1111-1389  | PTK_Ryk |
| cd05071 | 1107-1376  | PTKc_Src |
| cd05115 | 1122-1386  | PTKc_Zap-70 |
| cd05116 | 1122-1383  | PTKc_Syk |
| cd05107 | 1110-1380  | PTKc_PDGFR_beta |
| cd05088 | 1122-1380  | PTKc_Tie2 |
| cd05109 | 1108-1390  | PTKc_HER2 |
| cd00180 | 1122-1383  | PKc |
| cd05087 | 1119-1375  | PTKc_Aatyk1 |
| cd05042 | 1122-1374  | PTKc_Aatyk |
| cd05108 | 1108-1414  | PTKc_EGFR |
| cd14206 | 1122-1385  | PTKc_Aatyk3 |
| cd05110 | 1108-1390  | PTKc_HER4 |
| cd14058 | 1122-1389  | STKc_TAK1 |
| cd06606 | 1119-1375  | STKc_MAPKKK |
| cd05080 | 1113-1386  | PTKc_Tyk2_rpt2 |
| cd14205 | 1114-1384  | PTKc_Jak2_rpt2 |
| cd14061 | 1122-1384  | STKc_MLK |
| cd05111 | 1108-1390  | PTK_HER3 |
| cd14014 | 1117-1374  | STKc_PknB_like |
| cd14146 | 1122-1383  | STKc_MLK4 |
| cd05079 | 1119-1384  | PTKc_Jak1_rpt2 |
| cd05081 | 1114-1384  | PTKc_Jak3_rpt2 |
| cd14147 | 1114-1384  | STKc_MLK3 |
| cd05086 | 1119-1374  | PTKc_Aatyk2 |
| cd14148 | 1122-1384  | STKc_MLK2 |
| cd14059 | 1122-1384  | STKc_MAP3K12_13 |
| cd05037 | 1122-1383  | PTK_Jak_rpt1 |
| cd14066 | 1122-1324  | STKc_IRAK |
| cd14065 | 1122-1381  | PKc_LIMK_like |
| cd05122 | 1117-1374  | PKc_STE |
| cd14145 | 1110-1383  | STKc_MLK1 |
| cd14062 | 1122-1384  | STKc_Raf |
| cd14060 | 1123-1384  | STKc_MLTK |
| cd14150 | 1116-1384  | STKc_A-Raf |
| cd13978 | 1122-1376  | STKc_RIP |
| cd14151 | 1110-1384  | STKc_B-Raf |
| cd14064 | 1122-1386  | PKc_TNNI3K |
| cd14009 | 1122-1356  | STKc_ATG1_ULK_like |
| cd05117 | 1117-1345  | STKc_CAMK |
| cd14155 | 1122-1384  | PKc_TESK |
| cd14158 | 1120-1384  | STKc_IRAK4 |
| cd06623 | 1122-1374  | PKc_MAPKK_plant_like |
| cd14149 | 1110-1394  | STKc_C-Raf |
| cd06627 | 1122-1375  | STKc_Cdc7_like |
| cd14222 | 1156-1376  | STKc_LIMK2 |
| cd14156 | 1160-1384  | PKc_LIMK_like_unk |
| cd14154 | 1122-1376  | STKc_LIMK |
| cd13996 | 1119-1381  | STKc_EIF2AK |
| cd14202 | 1110-1376  | STKc_ULK1 |
| cd14039 | 1122-1330  | STKc_IKK_alpha |
| cd06628 | 1119-1380  | STKc_Byr2_like |
| cd13979 | 1122-1375  | STKc_Mos |
| cd08225 | 1115-1382  | STKc_Nek5 |
| cd14063 | 1122-1384  | PK_KSR |
| cd14161 | 1122-1352  | STKc_NUAK2 |
| cd06632 | 1120-1381  | STKc_MEKK1_plant |
| cd14000 | 1122-1374  | STKc_LRRK |
| cd08530 | 1115-1380  | STKc_CNK2-like |
| cd13989 | 1122-1330  | STKc_IKK |
| cd06611 | 1112-1381  | STKc_SLK_like |
| cd14003 | 1115-1381  | STKc_AMPK-like |
| cd14007 | 1118-1381  | STKc_Aurora |
| cd14069 | 1117-1390  | STKc_Chk1 |
| cd06917 | 1122-1373  | STKc_NAK1_like |
| cd06605 | 1119-1381  | PKc_MAPKK |
| cd06630 | 1122-1374  | STKc_MEKK1 |
| cd08215 | 1117-1383  | STKc_Nek |
| cd06643 | 1112-1322  | STKc_SLK |
| cd06644 | 1112-1381  | STKc_STK10 |
| cd06642 | 1112-1374  | STKc_STK25 |
| cd06613 | 1118-1321  | STKc_MAP4K3_like |
| cd14027 | 1156-1382  | STKc_RIP1 |
| cd08222 | 1118-1380  | STKc_Nek11 |
| cd06614 | 1122-1330  | STKc_PAK |
| cd05078 | 1121-1379  | PTK_Jak2_rpt1 |
| cd06608 | 1117-1317  | STKc_myosinIII_N_like |
| cd06621 | 1114-1375  | PKc_Pek1_like |
| cd14098 | 1118-1353  | STKc_Rad53_Cds1 |
| cd14008 | 1122-1354  | STKc_LKB1_CaMKK |
| cd13982 | 1122-1380  | STKc_IRE1 |
| cd06634 | 1109-1393  | STKc_TAO2 |
| cd14068 | 1122-1383  | STKc_LRRK2 |
| cd14038 | 1122-1330  | STKc_IKK_beta |
| cd06631 | 1122-1352  | STKc_YSK4 |
| cd08219 | 1118-1382  | STKc_Nek3 |
| cd06633 | 1101-1380  | STKc_TAO3 |
| cd06610 | 1118-1381  | STKc_OSR1_SPAK |
| cd14121 | 1122-1376  | STKc_ULK3 |
| cd06609 | 1117-1374  | STKc_MST3_like |
| cd14221 | 1158-1377  | STKc_LIMK1 |
| cd14201 | 1122-1376  | STKc_ULK2 |
| cd14664 | 1122-1324  | STK_BAK1_like |
| cd14120 | 1122-1376  | STKc_ULK1_2-like |
| cd14084 | 1113-1381  | STKc_Chk2 |
| cd05076 | 1116-1380  | PTK_Tyk2_rpt1 |
| cd06635 | 1094-1393  | STKc_TAO1 |
| cd06629 | 1122-1381  | STKc_Bck1_like |
| cd13988 | 1122-1345  | STKc_TBK1 |
| cd06647 | 1104-1373  | STKc_PAK_I |
| cd14208 | 1116-1383  | PTK_Jak3_rpt1 |
| cd14026 | 1119-1384  | STKc_RIP2 |
| cd06641 | 1107-1375  | STKc_MST3 |
| cd06655 | 1112-1373  | STKc_PAK2 |
| cd07840 | 1119-1340  | STKc_CDK9_like |
| cd14116 | 1120-1381  | STKc_Aurora-A |
| cd13992 | 1176-1379  | PK_GC |
| cd06622 | 1122-1392  | PKc_PBS2_like |
| cd06626 | 1123-1381  | STKc_MEKK4 |
| cd07866 | 1122-1323  | STKc_BUR1 |
| cd14159 | 1122-1324  | STKc_IRAK1 |
| cd08529 | 1122-1380  | STKc_FA2-like |
| cd05077 | 1122-1383  | PTK_Jak1_rpt1 |
| cd13997 | 1119-1380  | PKc_Wee1_like |
| cd06612 | 1112-1374  | STKc_MST1_2 |
| cd14080 | 1117-1330  | STKc_TSSK-like |
| cd14056 | 1122-1374  | STKc_TGFbR_I |
| cd06659 | 1146-1410  | STKc_PAK6 |
| cd06640 | 1112-1322  | STKc_MST4 |
| cd06618 | 1122-1392  | PKc_MKK7 |
| cd13998 | 1123-1383  | STKc_TGFbR-like |
| cd13994 | 1122-1381  | STKc_HAL4_like |
| cd14002 | 1115-1334  | STKc_STK36 |
| cd14117 | 1120-1381  | STKc_Aurora-B_like |
| cd08228 | 1115-1381  | STKc_Nek6 |
| cd14073 | 1118-1352  | STKc_NUAK |
| cd05123 | 1122-1340  | STKc_AGC |
| cd06654 | 1112-1373  | STKc_PAK1 |
| cd13975 | 1221-1384  | PKc_Dusty |
| cd13983 | 1122-1381  | STKc_WNK |
| cd06625 | 1122-1324  | STKc_MEKK3_like |
| cd06638 | 1112-1322  | STKc_myosinIIIA_N |
| cd06624 | 1122-1316  | STKc_ASK |
| cd14185 | 1167-1345  | STKc_DCKL3 |
| cd06656 | 1112-1346  | STKc_PAK3 |
| cd13993 | 1115-1373  | STKc_Pat1_like |
| cd07863 | 1122-1323  | STKc_CDK4 |
| cd08223 | 1167-1380  | STKc_Nek4 |
| cd07834 | 1117-1323  | STKc_MAPK |
| cd13985 | 1115-1384  | STKc_GAK_like |
| cd06607 | 1119-1374  | STKc_TAO |
| cd06646 | 1108-1352  | STKc_MAP4K5 |
| cd05581 | 1122-1345  | STKc_PDK1 |
| cd07830 | 1117-1325  | STKc_MAK_like |
| cd14048 | 1119-1374  | STKc_EIF2AK3_PERK |
| cd14052 | 1122-1322  | PTKc_Wee1_fungi |
| cd14025 | 1120-1387  | STKc_RIP4_like |
| cd14095 | 1166-1345  | STKc_DCKL |
| cd14010 | 1194-1340  | STKc_ULK4 |
| cd05118 | 1117-1324  | STKc_CMGC |
| cd07829 | 1122-1275  | STKc_CDK_like |
| cd05620 | 1122-1351  | STKc_nPKC_delta |
| cd14096 | 1115-1345  | STKc_RCK1-like |
| cd14001 | 1122-1384  | PKc_TOPK |
| cd06653 | 1115-1324  | STKc_MEKK3_like_u1 |
| cd14184 | 1167-1339  | STKc_DCKL2 |
| cd14106 | 1194-1337  | STKc_DRAK |
| cd06648 | 1146-1352  | STKc_PAK_II |
| cd14164 | 1117-1330  | STKc_TSSK6-like |
| cd14180 | 1176-1336  | STKc_MSK2_C |
| cd14099 | 1122-1381  | STKc_PLK |
| cd06645 | 1112-1325  | STKc_MAP4K3 |
| cd14137 | 1114-1340  | STKc_GSK3 |
| cd14166 | 1113-1345  | STKc_CaMKI_gamma |
| cd06652 | 1115-1324  | STKc_MEKK2 |
| cd14075 | 1119-1381  | STKc_NIM1 |
| cd08217 | 1122-1381  | STKc_Nek2 |
| cd05619 | 1115-1351  | STKc_nPKC_theta |
| cd14081 | 1118-1345  | STKc_BRSK1_2 |
| cd14012 | 1161-1374  | PK_eIF2AK_GCN2_rpt1 |
| cd14153 | 1122-1384  | PK_KSR2 |
| cd06639 | 1112-1322  | STKc_myosinIIIB_N |
| cd05578 | 1118-1351  | STKc_Yank1 |
| cd08229 | 1115-1379  | STKc_Nek7 |
| cd06616 | 1122-1394  | PKc_MKK4 |
| cd14198 | 1194-1380  | STKc_DRAK2 |
| cd14152 | 1122-1384  | STKc_KSR1 |
| cd14192 | 1122-1342  | STKc_MLCK3 |
| cd05577 | 1122-1373  | STKc_GRK |
| cd14188 | 1122-1381  | STKc_PLK2 |
| cd14031 | 1122-1373  | STKc_WNK3 |
| cd14006 | 1122-1345  | STKc_MLCK-like |
| cd07838 | 1122-1325  | STKc_CDK4_6_like |
| cd14067 | 1122-1374  | STKc_LRRK1 |
| cd06658 | 1146-1330  | STKc_PAK5 |
| cd08221 | 1119-1382  | STKc_Nek9 |
| cd08224 | 1115-1381  | STKc_Nek6_7 |
| cd14133 | 1118-1339  | PKc_DYRK_like |
| cd14054 | 1122-1324  | STKc_BMPR2_AMHR2 |
| cd07841 | 1117-1321  | STKc_CDK7 |
| cd06617 | 1115-1381  | PKc_MKK3_6 |
| cd14142 | 1114-1322  | STKc_ACVR1_ALK1 |
| cd05592 | 1122-1416  | STKc_nPKC_theta_like |
| cd14033 | 1122-1349  | STKc_WNK4 |
| cd14118 | 1167-1330  | STKc_CAMKK |
| cd13990 | 1117-1375  | STKc_TLK |
| cd06636 | 1118-1322  | STKc_MAP4K4_6_N |
| cd07845 | 1122-1342  | STKc_CDK10 |
| cd05607 | 1114-1330  | STKc_GRK7 |
| cd14169 | 1122-1338  | STKc_CaMKI_beta |
| cd08528 | 1122-1375  | STKc_Nek10 |
| cd14047 | 1113-1380  | STKc_EIF2AK2_PKR |
| cd05580 | 1114-1330  | STKc_PKA_like |
| cd06620 | 1133-1374  | PKc_Byr1_like |
| cd14179 | 1176-1333  | STKc_MSK1_C |
| cd14072 | 1115-1345  | STKc_MARK |
| cd13986 | 1117-1384  | STKc_16 |
| cd14086 | 1167-1330  | STKc_CaMKII |
| cd14103 | 1122-1345  | STKc_MLCK |
| cd14087 | 1122-1330  | STKc_PSKH1 |
| cd06637 | 1112-1322  | STKc_TNIK |
| cd14190 | 1122-1345  | STKc_MLCK2 |
| cd14209 | 1115-1345  | STKc_PKA |
| cd05590 | 1120-1340  | STKc_nPKC_eta |
| cd14140 | 1125-1383  | STKc_ACVR2b |
| cd14089 | 1175-1333  | STKc_MAPKAPK |
| cd05612 | 1115-1345  | STKc_PRKX_like |
| cd14167 | 1105-1340  | STKc_CaMKI_alpha |
| cd14043 | 1219-1376  | PK_GC-2D |
| cd08220 | 1119-1325  | STKc_Nek8 |
| cd14050 | 1122-1322  | PKc_Myt1 |
| cd13977 | 1117-1320  | STKc_PDIK1L |
| cd14097 | 1120-1346  | STKc_STK33 |
| cd07862 | 1122-1323  | STKc_CDK6 |
| cd07843 | 1165-1324  | STKc_CDC2L1 |
| cd14090 | 1175-1330  | STKc_Mnk |
| cd05616 | 1122-1340  | STKc_cPKC_beta |
| cd14168 | 1122-1340  | STKc_CaMKI_delta |
| cd14042 | 1147-1376  | PK_GC-A_B |
| cd14172 | 1193-1338  | STKc_MAPKAPK3 |
| cd14053 | 1124-1324  | STKc_ACVR2 |
| cd14144 | 1120-1373  | STKc_BMPR1 |
| cd14017 | 1117-1381  | STKc_TTBK |
| cd14105 | 1167-1345  | STKc_DAPK |
| cd08218 | 1167-1382  | STKc_Nek1 |
| cd13987 | 1122-1330  | STKc_SBK1 |
| cd06657 | 1147-1330  | STKc_PAK4 |
| cd05570 | 1122-1340  | STKc_PKC |
| cd14046 | 1122-1374  | STKc_EIF2AK4_GCN2_rpt2 |
| cd14194 | 1163-1344  | STKc_DAPK1 |
| cd14187 | 1112-1337  | STKc_PLK1 |
| cd07854 | 1119-1342  | STKc_MAPK4_6 |
| cd14104 | 1122-1342  | STKc_Titin |
| cd14175 | 1145-1345  | STKc_RSK1_C |
| cd14165 | 1120-1354  | STKc_TSSK1_2-like |
| cd14055 | 1122-1383  | STKc_TGFbR2_like |
| cd14076 | 1118-1330  | STKc_Kin4 |
| cd13968 | 1122-1272  | PKc_like |
| cd14032 | 1122-1373  | STKc_WNK2_like |
| cd14162 | 1116-1339  | STKc_TSSK4-like |
| cd05630 | 1120-1336  | STKc_GRK6 |
| cd07864 | 1117-1324  | STKc_CDK12 |
| cd14173 | 1176-1330  | STKc_Mnk2 |
| cd14183 | 1167-1351  | STKc_DCKL1 |
| cd06651 | 1112-1324  | STKc_MEKK3 |
| cd05631 | 1120-1330  | STKc_GRK4 |
| cd14030 | 1122-1345  | STKc_WNK1 |
| cd14077 | 1167-1354  | STKc_Kin1_2 |
| cd14176 | 1176-1345  | STKc_RSK2_C |
| cd14191 | 1122-1345  | STKc_MLCK1 |
| cd14094 | 1167-1352  | STKc_CASK |
| cd14082 | 1122-1351  | STKc_PKD |
| cd14196 | 1167-1344  | STKc_DAPK2 |
| cd06650 | 1194-1390  | PKc_MEK1 |
| cd14092 | 1175-1345  | STKc_MSK_C |
| cd14178 | 1176-1369  | STKc_RSK3_C |
| cd05632 | 1120-1336  | STKc_GRK5 |
| cd14045 | 1230-1379  | PK_GC_unk |
| cd14057 | 1163-1384  | PK_ILK |
| cd07842 | 1123-1275  | STKc_CDK8_like |
| cd14199 | 1136-1330  | STKc_CaMKK2 |
| cd14157 | 1125-1324  | STKc_IRAK2 |
| cd05615 | 1106-1340  | STKc_cPKC_alpha |
| cd14085 | 1122-1330  | STKc_CaMKIV |
| cd14177 | 1145-1349  | STKc_RSK4_C |
| cd14091 | 1122-1345  | STKc_RSK_C |
| cd14083 | 1107-1340  | STKc_CaMKI |
| cd07831 | 1118-1325  | STKc_MOK |
| cd14220 | 1120-1373  | STKc_BMPR1a |
| cd14119 | 1122-1375  | STKc_LKB1 |
| cd14223 | 1115-1330  | STKc_GRK2 |
| cd06619 | 1122-1374  | PKc_MKK5 |
| cd07832 | 1122-1275  | STKc_CCRK |
| cd14004 | 1150-1381  | STKc_PASK |
| cd14195 | 1167-1344  | STKc_DAPK3 |
| cd05589 | 1122-1340  | STKc_PKN |
| cd14170 | 1193-1332  | STKc_MAPKAPK2 |
| cd14193 | 1122-1339  | STKc_MLCK4 |
| cd07865 | 1122-1275  | STKc_CDK9 |
| cd14141 | 1125-1386  | STKc_ACVR2a |
| cd07855 | 1118-1322  | STKc_ERK5 |
| cd14020 | 1121-1324  | STKc_KIS |
| cd14219 | 1114-1373  | STKc_BMPR1b |
| cd07839 | 1122-1340  | STKc_CDK5 |
| cd14197 | 1225-1337  | STKc_DRAK1 |
| cd05591 | 1122-1340  | STKc_nPKC_epsilon |
| cd05605 | 1120-1322  | STKc_GRK4_like |
| cd13995 | 1125-1381  | STKc_MAP3K8 |
| cd07853 | 1118-1324  | STKc_NLK |
| cd05633 | 1120-1330  | STKc_GRK3 |
| cd14229 | 1122-1343  | STKc_HIPK3 |
| cd07836 | 1122-1339  | STKc_Pho85 |
| cd14210 | 1118-1340  | PKc_DYRK |
| cd05572 | 1122-1330  | STKc_cGK |
| cd14663 | 1118-1330  | STKc_SnRK3 |
| cd14111 | 1236-1355  | STKc_SPEG_rpt2 |
| cd14227 | 1122-1343  | STKc_HIPK2 |
| cd05611 | 1193-1345  | STKc_Rim15_like |
| cd14228 | 1122-1343  | STKc_HIPK1 |
| cd14011 | 1204-1385  | PK_SCY1_like |
| cd14143 | 1122-1373  | STKc_TGFbR1_ACVR1b_ACVR1c |
| cd05579 | 1125-1345  | STKc_MAST_like |
| cd14200 | 1137-1330  | STKc_CaMKK1 |
| cd14186 | 1122-1381  | STKc_PLK4 |
| cd06649 | 1133-1390  | PKc_MEK2 |
| cd06615 | 1194-1390  | PKc_MEK |
| cd05628 | 1119-1337  | STKc_NDR1 |
| cd14163 | 1146-1320  | STKc_TSSK3-like |
| cd14110 | 1147-1345  | STKc_obscurin_rpt2 |
| cd05593 | 1103-1342  | STKc_PKB_gamma |
| cd05595 | 1122-1408  | STKc_PKB_beta |
| cd05617 | 1114-1330  | STKc_aPKC_zeta |
| cd14211 | 1122-1334  | STKc_HIPK |
| cd05627 | 1193-1337  | STKc_NDR2 |
| cd05610 | 1114-1275  | STKc_MASTL |
| cd14189 | 1120-1381  | STKc_PLK3 |
| cd05582 | 1122-1339  | STKc_RSK_N |
| cd05594 | 1112-1342  | STKc_PKB_alpha |
| cd14071 | 1146-1345  | STKc_SIK |
| cd14005 | 1122-1381  | STKc_PIM |
| cd14079 | 1115-1320  | STKc_AMPK_alpha |
| cd05622 | 1066-1334  | STKc_ROCK1 |
| cd14041 | 1118-1373  | STKc_TLK2 |
| cd05618 | 1193-1373  | STKc_aPKC_iota |
| cd14049 | 1122-1323  | STKc_EIF2AK1_HRI |
| cd08216 | 1147-1265  | PK_STRAD |
| cd13991 | 1122-1314  | STKc_NIK |
| cd14174 | 1122-1330  | STKc_Mnk1 |
| cd05608 | 1120-1324  | STKc_GRK1 |
| cd05586 | 1122-1353  | STKc_Sck1_like |
| cd05625 | 1119-1373  | STKc_LATS1 |
| cd14070 | 1120-1352  | STKc_HUNK |
| cd05624 | 1113-1334  | STKc_MRCK_beta |
| cd14018 | 1204-1325  | STKc_PINK1 |
| cd14171 | 1176-1333  | STKc_MAPKAPK5 |
| cd14074 | 1146-1339  | STKc_SNRK |
| cd07857 | 1117-1329  | STKc_MPK1 |
| cd05606 | 1122-1330  | STKc_beta_ARK |
| cd14108 | 1122-1339  | STKc_SPEG_rpt1 |
| cd05598 | 1117-1330  | STKc_LATS |
| cd08226 | 1142-1330  | PK_STRAD_beta |
| cd14040 | 1118-1340  | STKc_TLK1 |
| cd05623 | 1113-1334  | STKc_MRCK_alpha |
| cd13981 | 1122-1277  | STKc_Bub1_BubR1 |
| cd14115 | 1146-1337  | STKc_Kalirin_C |
| cd14130 | 1118-1337  | STKc_TTBK1 |
| cd07861 | 1117-1275  | STKc_CDK1_euk |
| cd05587 | 1230-1343  | STKc_cPKC |
| cd14129 | 1118-1391  | STKc_TTBK2 |
| cd05603 | 1193-1340  | STKc_SGK2 |
| cd14093 | 1167-1320  | STKc_PhKG |
| cd14107 | 1236-1374  | STKc_obscurin_rpt1 |
| pfam14670 | 987-1021  | FXa_inhibition |
| cl21504 | 987-1021  | EGF_CA superfamily |
| cd14181 | 1175-1274  | STKc_PhKG2 |
| cd07858 | 1110-1333  | STKc_TEY_MAPK |
| cd14109 | 1163-1345  | PK_Unc-89_rpt1 |
| cd05602 | 1118-1340  | STKc_SGK1 |
| cd07876 | 1119-1322  | STKc_JNK2 |
| cd07868 | 1122-1324  | STKc_CDK8 |
| cd05621 | 1119-1334  | STKc_ROCK2 |
| cd07848 | 1238-1334  | STKc_CDKL5 |
| cd07860 | 1122-1275  | STKc_CDK2_3 |
| cd14015 | 1118-1274  | STKc_VRK |
| cd14112 | 1112-1337  | STKc_Unc-89_rpt2 |
| cd05588 | 1193-1330  | STKc_aPKC |
| cd05609 | 1194-1373  | STKc_MAST |
| cd07846 | 1125-1381  | STKc_CDKL2_3 |
| smart00192 | 441-467  | LDLa |
| cl00104 | 441-467  | LDLa superfamily |
| pfam07714 | 1116-1383  | Pkinase_Tyr |
| pfam00629 | 480-634  | MAM |
| smart00219 | 1116-1383  | TyrKc |
| smart00221 | 1116-1383  | STYKc |
| smart00220 | 1117-1381  | S_TKc |
| pfam00069 | 1116-1381  | Pkinase |
| COG0515 | 1117-1372  | SPS1 |
| PHA03209 | 1115-1400  | PHA03209 |
| PHA03212 | 1167-1322  | PHA03212 |
| PTZ00283 | 1112-1380  | PTZ00283 |
| PRK13184 | 1118-1373  | pknD |
| PLN00034 | 1167-1381  | PLN00034 |
| PTZ00267 | 1193-1374  | PTZ00267 |
| PTZ00266 | 1118-1335  | PTZ00266 |
| PTZ00263 | 1122-1352  | PTZ00263 |
| PTZ00426 | 1109-1340  | PTZ00426 |
| PTZ00036 | 1106-1339  | PTZ00036 |
| PHA02988 | 1173-1384  | PHA02988 |
| PTZ00024 | 1165-1324  | PTZ00024 |
| PHA03210 | 1167-1329  | PHA03210 |
| PHA03207 | 1101-1322  | PHA03207 |
| PHA03211 | 1118-1321  | PHA03211 |
| TIGR03903 | 1146-1339  | TOMM_kin_cyc |
| smart00137 | 480-631  | MAM |
| pfam14531 | 1105-1373  | Kinase-like |
Ontology Information
| HPRD ID | 8870 |    
|---|---|
| Molecular Class | Receptor tyrosine kinase |
| Molecular Function | Protein binding (GO:0005515); Chaperone activity (GO:0003754) |
| Biological Process | Signal transduction (GO:0007165); Anti-apoptosis (GO:0006916)   |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9UM73 | DB00171 | Adenosine triphosphate | SmallMoleculeDrug |
| Q9UM73 | DB08865 | Crizotinib | SmallMoleculeDrug |
| Q9UM73 | DB09063 | Ceritinib | SmallMoleculeDrug |
| Q9UM73 | DB11363 | Alectinib | SmallMoleculeDrug |
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
