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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21636702 | 2011 | Cell line : - Source : - Sample Type : CRC tumor No. of Sample : 51 CRCs, 9 adenomas, 19 NCs from CRC patients (CRC-NCs), and 34 NCs from neoplasia-free subjects Stage : - | Methylation specific PCR ,Real-time quantitative MSP | Hypermethylation | - | CRC-NCs were significantly distinguished from control NCs by methylation of ALX3 (P<1�10(-4)). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / PRD class |
| Description | This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008] | Chromosome | 1 |
| Location | 1p13.3 |
| Start | 110602997 |
| End | 110613322 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 10326 |
| OMIM ID | 606014 |
| HGNC ID | HGNC:449 |
| Unigene ID | Hs.669953 |
| Ensembl ID | ENSG00000156150 |
| PharmGKB ID | PA24754 |
mRNA Information
| mRNA ID | NM_006492.2 |
|---|---|
| Exon | join(1..365,5798..6114,9138..9266,9660..10326) | mRNA Sequence | Download Select all |
| Length | 1478 |
Protein Information
| Protein ID | NP_006483.2 |
|---|---|
| Protein Name | ALX homeobox 3 |
| Molecular Wt. (Da) | 36804 |
| Protein Sequence | Download Select all |
| Length | 343 |
| Uniprot ID | P49736 |
| Ensembl Protein ID | ENSP00000265056 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 154-212 | homeodomain |
| cl00084 | 154-212 | homeodomain superfamily |
| pfam00046 | 154-210 | Homeobox |
| smart00389 | 153-209 | HOX |
| COG5576 | 150-222 | COG5576 |
| PRK12323 | 13-131 | PRK12323 |
| PRK14959 | 13-106 | PRK14959 |
Ontology Information
| HPRD ID | 9094 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.