Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ALX4 | 60529 | ALX homeobox 4  | 11 | FPP, PFM, KIAA1788  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20140221    | 2010 | Cell line : - Source : - Sample Type : Blood plasma No. of Sample : 128 individuals (cohort I - exploratory study: 73 cases / 55 controls), 76 individuals (cohort II - validation study: 54 cases / 22 controls) Stage : - | HeavyMethyl technique, Real Time RT-PCR | Methylation | - | Methylated DNA from advanced precancerous colorectal lesions can be detected using a panel of two DNA methylation markers, ALX4 and SEPT9. The presence of both SEPT9 and ALX4 markers was analysed in cohort II and was observed in 5% of controls (1/22) and 37% of patients with polyps (18/49). Interestingly, also 3/5 (60%) patients with colorectal cancer were tested positive by the two marker panel in plasma. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Homeoboxes / PRD class |
| Description | This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart.   | Chromosome | 11 |
| Location | 11p11.2 |
| Start | 44260438   |
| End | 44319220   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 58783   |
| OMIM ID | 605420    |
| HGNC ID | HGNC:450    |
| Unigene ID | Hs.436055    |
| Ensembl ID | ENSG00000052850    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | XM_011520265.1 |
|---|---|
| Exon | join(1..2330,9534..9624,43563..43873,51599..51727, 54038..58783)   | mRNA Sequence |    Download   Select all |
| Length | 5466   |
CDS Information
| Location | join(9159..9624,43563..43873,51599..51727,54038..54367) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS31468.1 |    
Protein Information
| Protein ID | NP_068745.2 |
|---|---|
| Protein Name | ALX homeobox 4 |
| Molecular Wt. (Da) | 44110 |
| Protein Sequence |    Download   Select all |
| Length | 411   |
| Uniprot ID | P17931 |    
| Ensembl Protein ID | ENSP00000254301   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 8092 |    ALX1 |    3316 |    NP_008913.2 |    in vitro |    9847249    |
| 51176 |    LEF1 |    1075 |    NP_057353.1 |    in vitro |    11696550    |
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 2M0C |
|---|---|
| Resolution | |
| Method | SOLUTION NMR |
| Chains | A   |
| Molecule | Homeobox protein aristaless-like 4   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00086 | 215-273  | homeodomain |
| cl00084 | 215-273  | homeodomain superfamily |
| pfam00046 | 215-271  | Homeobox |
| smart00389 | 214-270  | HOX |
| pfam03826 | 387-406  | OAR |
| cl08404 | 387-406  | OAR superfamily |
| COG5576 | 202-299  | COG5576 |
Ontology Information
| HPRD ID | 2796 |    
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Immune response (GO:0006955)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
