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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 12213712 | 2002 | Cell line : - Source : Radical Prostatectomy Series and from the Rapid Autopsy Program at the University of Michigan Sample Type : - No. of Sample : - Stage : - | Immunohistochemistry and tissue microarray, western blotting | Up-regulation | - | Examination of colorectal cancer, which is not hormone regulated, demonstrated high levels of AMACR expression in well to moderately differentiated tumors and weak expression in anaplastic colorectal cancers. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. | Chromosome | 5 |
| Location | 5p13.2 |
| Start | 33986986 |
| End | 34008115 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 21130 |
| OMIM ID | 604489 |
| HGNC ID | HGNC:451 |
| Unigene ID | Hs.508343 |
| Ensembl ID | ENSG00000242110 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_203382.2 |
|---|---|
| Exon | join(1..343,2217..2360,9289..9475,18614..21130) | mRNA Sequence | Download Select all |
| Length | 2603 |
CDS Information
| Location | join(97..343,2217..2360,3382..3542,9289..9475, 18614..19005,19755..19808) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS54836.1 |
Protein Information
| Protein ID | NP_001161067.1 |
|---|---|
| Protein Name | alpha-methylacyl-CoA racemase |
| Molecular Wt. (Da) | 43729 |
| Protein Sequence | Download Select all |
| Length | 394 |
| Uniprot ID | Q15726 |
| Ensembl Protein ID | ENSP00000356162 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
| EC | 5.1.99.4 |
|---|---|
| Name | alpha-methylacyl-CoA racemase |
| Class | Isomerases; Racemases and epimerases; Acting on other compounds |
| Sysname | 2-methylacyl-CoA 2-epimerase |
| Substrate | (2S)-2-methylacyl-CoA [CPD:C05232] |
| Product | (2R)-2-methylacyl-CoA [CPD:C05329] |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Metabolic pathways | hsa01100 |
| Peroxisome | hsa04146 |
| Primary bile acid biosynthesis | hsa00120 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| COG1804 | 3-373 | CaiB |
| cl19215 | 3-373 | CoA_transf_3 superfamily |
| pfam02515 | 53-244 | CoA_transf_3 |
| PRK05398 | 2-373 | PRK05398 |
| TIGR03253 | 2-373 | oxalate_frc |
| PRK11430 | 3-188 | PRK11430 |
| PRK03525 | 3-381 | PRK03525 |
| TIGR04253 | 3-373 | mesacon_CoA_iso |
Ontology Information
| HPRD ID | 1287 |
|---|---|
| Molecular Class | Enzyme: Racemase |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.