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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ANGPT1 284 angiopoietin 1  8KIAA0003, Ang1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22496856   2012Cell line : -

Source : Departments of General Surgery in the Xijing Hospital and the Tangdu Hospital

Sample Type : CRC tumor and Normal tissue

No. of Sample : 496

Stage : TNM Stage I-IV

GenotypingPolymorhpism- rs1954727 in ANGPT1 gene might be a prognostic biomarker for the overall survival of CRC patients, especially in those receiving chemotherapy.


Gene Details



Chromosome 8 - NC_000008.11 (107249482..107498026, complement)

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Gene Type protein coding
Gene Family Fibrinogen C domain containing
Description Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[  
Chromosome 8
Location 8q23.1
Start 107249482  
End 107498026  
Strand -  
Gene Sequence

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Length 248545  
OMIM ID 601667   
HGNC ID HGNC:484   
Unigene ID Hs.369675   
Ensembl ID ENSG00000154188   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001199859.1
Exon join(1..765,150930..151085,161756..161877,175899..176128, 194660..194787,203990..204091,213179..213345, 233676..233806,246012..248545)  
mRNA Sequence

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Length 4338  



CDS Information


   
Locationjoin(469..765,150930..151085,161756..161877, 175899..176128,194660..194787,203990..204091, 213179..213345,233676..233806,246012..246172)
CDS Sequence

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CCDS ID CCDS56551.1



Protein Information


      
Protein IDNP_001137.2
Protein Nameangiopoietin 1
Molecular Wt. (Da)55389
Protein Sequence

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Length 498  
Uniprot IDP39905
Ensembl Protein ID ENSP00000317145  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3678ITGA5627NP_002196.2in vitro15781448   
7010TEK2571NP_000450.2in vitro;in vivo97   237   098   980   223   100   000   000   000   000   


Pathway Information


                              
Pathway Name Pathway ID
HIF-1 signaling pathway hsa04066
PI3K-Akt signaling pathway hsa04151
Rap1 signaling pathway hsa04015
Ras signaling pathway hsa04014
Rheumatoid arthritis hsa05323


Structure Information


PDB ID4EPU
Resolution2.1
MethodX-RAY DIFFRACTION
Chains A,B  
Molecule Angiopoietin-1  
Model View



Domain Information




ID Location Description
cd00087281-496  FReD
cl00085281-496  FReD superfamily
smart00186283-496  FBG
pfam00147284-496  Fibrinogen_C
pfam0795677-210  DUF1690
cl0682477-210  DUF1690 superfamily
COG041981-256  SbcC
COG119681-280  Smc
TIGR04523105-258  Mplasa_alph_rch
TIGR0216855-256  SMC_prok_B
COG437283-255  COG4372
COG132291-244  RmuC
TIGR0452381-253  Mplasa_alph_rch
TIGR0452382-250  Mplasa_alph_rch
pfam14992101-258  TMCO5
TIGR0216979-264  SMC_prok_A
TIGR0216877-261  SMC_prok_B
COG119655-264  Smc
pfam11559133-238  ADIP
COG041986-254  SbcC
pfam0401289-216  PspA_IM30
COG494265-250  EnvC
PRK10935122-255  PRK10935
PRK12704139-235  PRK12704
TIGR0216983-258  SMC_prok_A
TIGR0063481-250  recN
COG119682-240  Smc
TIGR0216982-261  SMC_prok_A
TIGR04523154-254  Mplasa_alph_rch
TIGR0161260-263  235kDa-fam
pfam1385190-259  GAS
TIGR0216880-263  SMC_prok_B
COG1196128-256  Smc
PRK03918139-261  PRK03918
TIGR04523136-247  Mplasa_alph_rch


Ontology Information


   
HPRD ID15925
Molecular ClassGrowth factor
Molecular FunctionHormone activity (GO:0005179)
Biological ProcessSignal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO