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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22496856    | 2012 | Cell line : - Source : Departments of General Surgery in the Xijing Hospital and the Tangdu Hospital Sample Type : CRC tumor and Normal tissue No. of Sample : 496 Stage : TNM Stage I-IV | Genotyping | Polymorhpism | - | rs1954727 in ANGPT1 gene might be a prognostic biomarker for the overall survival of CRC patients, especially in those receiving chemotherapy. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | Fibrinogen C domain containing |
| Description | Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[   | Chromosome | 8 |
| Location | 8q23.1 |
| Start | 107249482   |
| End | 107498026   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 248545   |
| OMIM ID | 601667    |
| HGNC ID | HGNC:484    |
| Unigene ID | Hs.369675    |
| Ensembl ID | ENSG00000154188    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_001199859.1 |
|---|---|
| Exon | join(1..765,150930..151085,161756..161877,175899..176128, 194660..194787,203990..204091,213179..213345, 233676..233806,246012..248545)   | mRNA Sequence |    Download   Select all |
| Length | 4338   |
CDS Information
| Location | join(469..765,150930..151085,161756..161877, 175899..176128,194660..194787,203990..204091, 213179..213345,233676..233806,246012..246172) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS56551.1 |    
Protein Information
| Protein ID | NP_001137.2 |
|---|---|
| Protein Name | angiopoietin 1 |
| Molecular Wt. (Da) | 55389 |
| Protein Sequence |    Download   Select all |
| Length | 498   |
| Uniprot ID | P39905 |    
| Ensembl Protein ID | ENSP00000317145   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3678 |    ITGA5 |    627 |    NP_002196.2 |    in vitro |    15781448    |
| 7010 |    TEK |    2571 |    NP_000450.2 |    in vitro;in vivo |    97   237   098   980   223   100   000   000   000   000    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| HIF-1 signaling pathway |    hsa04066 |    
| PI3K-Akt signaling pathway |    hsa04151 |    
| Rap1 signaling pathway |    hsa04015 |    
| Ras signaling pathway |    hsa04014 |    
| Rheumatoid arthritis |    hsa05323 |    
Structure Information
| PDB ID | 4EPU |
|---|---|
| Resolution | 2.1 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B   |
| Molecule | Angiopoietin-1   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00087 | 281-496  | FReD |
| cl00085 | 281-496  | FReD superfamily |
| smart00186 | 283-496  | FBG |
| pfam00147 | 284-496  | Fibrinogen_C |
| pfam07956 | 77-210  | DUF1690 |
| cl06824 | 77-210  | DUF1690 superfamily |
| COG0419 | 81-256  | SbcC |
| COG1196 | 81-280  | Smc |
| TIGR04523 | 105-258  | Mplasa_alph_rch |
| TIGR02168 | 55-256  | SMC_prok_B |
| COG4372 | 83-255  | COG4372 |
| COG1322 | 91-244  | RmuC |
| TIGR04523 | 81-253  | Mplasa_alph_rch |
| TIGR04523 | 82-250  | Mplasa_alph_rch |
| pfam14992 | 101-258  | TMCO5 |
| TIGR02169 | 79-264  | SMC_prok_A |
| TIGR02168 | 77-261  | SMC_prok_B |
| COG1196 | 55-264  | Smc |
| pfam11559 | 133-238  | ADIP |
| COG0419 | 86-254  | SbcC |
| pfam04012 | 89-216  | PspA_IM30 |
| COG4942 | 65-250  | EnvC |
| PRK10935 | 122-255  | PRK10935 |
| PRK12704 | 139-235  | PRK12704 |
| TIGR02169 | 83-258  | SMC_prok_A |
| TIGR00634 | 81-250  | recN |
| COG1196 | 82-240  | Smc |
| TIGR02169 | 82-261  | SMC_prok_A |
| TIGR04523 | 154-254  | Mplasa_alph_rch |
| TIGR01612 | 60-263  | 235kDa-fam |
| pfam13851 | 90-259  | GAS |
| TIGR02168 | 80-263  | SMC_prok_B |
| COG1196 | 128-256  | Smc |
| PRK03918 | 139-261  | PRK03918 |
| TIGR04523 | 136-247  | Mplasa_alph_rch |
Ontology Information
| HPRD ID | 15925 |    
|---|---|
| Molecular Class | Growth factor |
| Molecular Function | Hormone activity (GO:0005179) |
| Biological Process | Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
