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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
- PPi
- Pathway
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20924372 | 2010 | Cell line : - Source : - Sample Type : Serum sample No. of Sample : 90 CRA and 33 healthy Control Stage : - | real timeRT- PCR, Western blotting, ELISA, Immunohistochemistry | Up-regulation | - | Serum Ang-2 is a candidate biomarker for outcome of patients with metastatic CRC treated with bevacizumab-containing therapy. Serum Ang-2 levels were significantly elevated in patients with metastatic CRC compared with healthy |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Fibrinogen C domain containing |
| Description | The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. | Chromosome | 8 |
| Location | 8p23 |
| Start | 6499651 |
| End | 6563263 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 63613 |
| OMIM ID | 601922 |
| HGNC ID | HGNC:485 |
| Unigene ID | Hs.583870 |
| Ensembl ID | ENSG00000091879 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_024596.3 |
|---|---|
| Exon | complement(63335..63412) | mRNA Sequence | Download Select all |
| Length | 5267 |
CDS Information
| Location | complement(63335..63412) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS43689.1 |
Protein Information
| Protein ID | NP_001112359.1 |
|---|---|
| Protein Name | angiopoietin 2 |
| Molecular Wt. (Da) | 54838 |
| Protein Sequence | Download Select all |
| Length | 495 |
| Uniprot ID | P15291 |
| Ensembl Protein ID | ENSP00000369055 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 284 | ANGPT1 | 3392 | NP_001137.2 | in vitro;in vivo | 9204896 |
| 7010 | TEK | 2571 | NP_000450.2 | in vivo | 9723709 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| HIF-1 signaling pathway | hsa04066 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
Structure Information
| PDB ID | 1Z3S |
|---|---|
| Resolution | 2.35 |
| Method | X-RAY DIFFRACTION |
| Chains | A, B |
| Molecule | Angiopoietin-2 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00087 | 281-493 | FReD |
| cl00085 | 281-493 | FReD superfamily |
| smart00186 | 280-494 | FBG |
| pfam00147 | 280-493 | Fibrinogen_C |
| PRK13922 | 174-239 | PRK13922 |
| cl19252 | 174-239 | MreC superfamily |
| PRK12704 | 101-234 | PRK12704 |
| COG1196 | 72-258 | Smc |
| COG1196 | 83-262 | Smc |
| TIGR02168 | 63-256 | SMC_prok_B |
| COG0419 | 72-233 | SbcC |
| COG1196 | 79-258 | Smc |
| TIGR02169 | 70-258 | SMC_prok_A |
| COG1196 | 130-279 | Smc |
| COG1196 | 66-258 | Smc |
| TIGR03319 | 136-256 | RNase_Y |
| TIGR04523 | 94-257 | Mplasa_alph_rch |
| TIGR01612 | 81-266 | 235kDa-fam |
| PRK03918 | 84-234 | PRK03918 |
| COG0419 | 95-234 | SbcC |
| pfam12072 | 133-232 | DUF3552 |
| TIGR02168 | 126-269 | SMC_prok_B |
| TIGR02169 | 81-280 | SMC_prok_A |
| TIGR04523 | 72-234 | Mplasa_alph_rch |
| TIGR02169 | 72-199 | SMC_prok_A |
| COG1579 | 94-234 | COG1579 |
| TIGR02169 | 79-234 | SMC_prok_A |
| TIGR02169 | 96-234 | SMC_prok_A |
Ontology Information
| HPRD ID | 413 |
|---|---|
| Molecular Class | Ligand |
| Molecular Function | Auxiliary transport protein activity (GO:0015457) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.