Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ANO1 | 55107 | anoctamin 1, calcium activated chloride channel | 11 | TAOS2, FLJ10261, DOG1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25541940 | 2014 | Cell line : HCT8, SW480, SW620, HCT116, LS174T Source : ATCC Sample Type : - No. of Sample : - Stage : - | Flow cytometry ,RT-PCR, western blotting and immunofluorescence labeling, MTT, wound-healing and transwell assays,Cell migration and invasion assays | Up-regulation | - | TMEM16A CaCC is involved in growth, migration and invasion of metastatic CRC cells and provide evidence for TMEM16A as a potential drug target for treating metastatic colorectal carcinoma. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Ion channels / Chloride channels : Calcium activated : Anoctamins |
| Description | - | Chromosome | 11 |
| Location | 11q13.2 |
| Start | 69924408 |
| End | 70035651 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 111244 |
| OMIM ID | 610108 |
| HGNC ID | HGNC:21625 |
| Unigene ID | Hs.503074 |
| Ensembl ID | ENSG00000131620 |
| PharmGKB ID | PA164715378 |
Protein Information
| Protein ID | NP_060513.5 |
|---|---|
| Protein Name | anoctamin 1, calcium activated chloride channel |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 986 |
| Uniprot ID | Q9HAV5 |
| Ensembl Protein ID | ENSP00000253392 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam04547 | 320-927 | Anoctamin |
| cl21726 | 320-927 | Anoctamin superfamily |
Ontology Information
| HPRD ID | 5661 |
|---|---|
| Molecular Class | Integral membrane protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q5XXA6 | DB04941 | Crofelemer | SmallMoleculeDrug |