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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ANXA2 302 Annexin A2  15P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
11745218   2001Cell line : -

Source : ATCC, Nara Medical University.

Sample Type : CRC tumor and Normal tissue

No. of Sample : 105

Stage : TNM Stage I-IV

Western Blotting, ImmunostainingUp-regulation-Annexin II and tenascin-C are overexpressed in advanced colorectal carcinoma and that they may be related to the progression and metastatic spread of colorectal carcinoma.

17542627   2007Cell line : -

Source : Department of General Surgery, Xiangya Hospital, Central South University, China

Sample Type : CRC tumor and Normal tissue

No. of Sample : 10

Stage : -

IPG-2-D Gelelctrophoresis, MALDI-TOF-MS, Western Blotting, Tissue Microarray and ImmunohistochemistryUp-regulation-The increased expression of HSP-27, GST, and Annexin II, but decreased expression of L-FABP suggests a significantly elevated incidence of LNM in CRC.

15526283   2005Cell line : HT 29,Caco 2

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Up-regulation-Human colon adenocarcinoma cell differentiation is associated with an up-regulation of AnxA1, AnxA2, and AnxA5 and with a subcellular relocation of these proteins.

18071363   2008Cell line : -

Source : Aberdeen colorectal tumour bank.

Sample Type : CRC tumor and Normal tissue

No. of Sample : 10

Stage : Duke Stage C

2-D Gelelectrophoresis, MALDITOF MS, ImmunohistochemistryUp-regulation--

22855149   2012Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : -

Stage : -

-Up-regulation-Anxa2 might be used as a potential biomarker for the diagnosis, treatment and prognosis of certain tumors.

Anxa2 up-regulation was related to the development, invasion, metastasis and drug resistance of hepatocellular carcinoma, colorectal cancer.

23489866   2013Cell line : -

Source : -

Sample Type : CRC tumor and Normal tissue

No. of Sample : 150

Stage : -

ImmunohistochemistryUp-regulation-ANXA2 is a biomarker with diagnostic and prognostic potential for patients with CRC.

ANXA2 was found to be strongly expressed in poorly differentiated tumours (P < 0.001), late stage (P = 0.020) and lymph node positivity (P = 0.002). ANXA2 expression was significantly related to recurrence (P < 0.001) and survival (P = 0.002)


Gene Details



Chromosome: 15; NC_000015.9 (60639350..60690185, complement)

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Gene Type protein coding
Gene Family Annexins
Description This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]  
Chromosome 15
Location 15q22.2
Start 60347151  
End 60397986  
Strand -  
Gene Sequence

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Length 50836  
OMIM ID 151740   
HGNC ID HGNC:537   
Unigene ID Hs.511605    
Ensembl ID ENSG00000182718   
PharmGKB ID PA24827   

mRNA Information


mRNA ID NM_004039.2
Exon join(1..44,11901..11959,15546..15645,33464..33558, 36933..37046,40751..40841,41989..42068,43774..43833, 45511..45604,46168..46263,46736..46794,48790..48912, 50298..50836)  
mRNA Sequence

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Length 1563  



CDS Information


   
Locationjoin(74..116,11901..11959,15546..15645,33464..33558, 36933..37046,40751..40841,41989..42068,43774..43833, 45511..45604,46168..46263,46736..46794,48790..48912, 50298..50357)
CDS Sequence

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CCDS ID CCDS32256.1



Protein Information


      
Protein IDNP_001002857.1
Protein NameAnnexin A2
Molecular Wt. (Da)38473
Protein Sequence

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Length 339  
Uniprot IDP27037
Ensembl Protein ID ENSP00000241416  



Post-translational Modification Information (Source : HPRD)


Residue Type site
YPhosphorylation24
YPhosphorylation42
YPhosphorylation24
SPhosphorylation26
SPhosphorylation44
SPhosphorylation26
SPhosphorylation2
SPhosphorylation20
CDisulfide Bridge133;262
YPhosphorylation30
YPhosphorylation48
YPhosphorylation30
SPhosphorylation18
SPhosphorylation36
SPhosphorylation18
CS-Nitrosylation133
CS-Nitrosylation151
CS-Nitrosylation133
YPhosphorylation93;-
YPhosphorylation75;-
YPhosphorylation75;-
YPhosphorylation206;-
YPhosphorylation188;-
YPhosphorylation188;-
YPhosphorylation217;-
YPhosphorylation199;-
YPhosphorylation199;-
YPhosphorylation256;-
YPhosphorylation238;-
YPhosphorylation238;-
YPhosphorylation334;-
YPhosphorylation316;-
YPhosphorylation316;-
YPhosphorylation335;-
YPhosphorylation317;-
YPhosphorylation317;-
YPhosphorylation336;-
YPhosphorylation318;-
YPhosphorylation318;-
SPhosphorylation2;-
SPhosphorylation12;-
SPhosphorylation30;-
SPhosphorylation12;-
TPhosphorylation19;-
TPhosphorylation37;-
TPhosphorylation19;-
SPhosphorylation22;-
SPhosphorylation40;-
SPhosphorylation22;-
TPhosphorylation3;-
TPhosphorylation21;-
TPhosphorylation3;-
SPhosphorylation127
SPhosphorylation145
SPhosphorylation127
TPhosphorylation123
TPhosphorylation141
TPhosphorylation123
KAcetylation313
KAcetylation331
KAcetylation313
KAcetylation302
KAcetylation320
KAcetylation302
KAcetylation157
KAcetylation175
KAcetylation157
KAcetylation227
KAcetylation245
KAcetylation227
KAcetylation148
KAcetylation166
KAcetylation148
KAcetylation115
KAcetylation133
KAcetylation115
KAcetylation152
KAcetylation170
KAcetylation152
KAcetylation104
KAcetylation122
KAcetylation104
KAcetylation279
KAcetylation297
KAcetylation279
SPhosphorylation184
SPhosphorylation202
SPhosphorylation184
YPhosphorylation147
YPhosphorylation165
YPhosphorylation147
TPhosphorylation153
TPhosphorylation171
TPhosphorylation153

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
350APOH728NP_000033.2in vitro;in vivo10809787   
634CEACAM1191NP_001703.2in vitro;in vivo14522961   
998CDC42309NP_001782.1in vitro;in vivo17254974   
1508CTSB287NP_680090.1in vivo10777578   
2885GRB2150NP_002077.1in vitro7510700   
4267CD992434NP_002405.1yeast 2-hybrid15388255   
6277S100A6237NP_055439.1in vitro1999197   
6281S100A10232NP_002957.1in vitro8   898   866   214   828   810   000   000   


Pathway Information


No matching records could be found.

Structure Information


PDB ID1W7B
Resolution1.52
MethodX-RAY DIFFRACTION
Chains A  
Molecule ANNEXIN A2  
Model View



Domain Information




ID Location Description
pfam00191109-174  Annexin
cl02574109-174  Annexin superfamily
pfam00191269-334  Annexin
cl02574269-334  Annexin superfamily
smart00335122-174  ANX
smart00335282-334  ANX
pfam0019137-102  Annexin
cl0257437-102  Annexin superfamily
smart0033550-102  ANX
pfam00191193-259  Annexin
cl02574193-259  Annexin superfamily
smart00335207-259  ANX


Ontology Information


   
HPRD ID25
Molecular ClassCalcium binding protein
Molecular FunctionReceptor signaling protein serine/threonine kinase activity (GO:0004702)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P07355DB00031TenecteplaseBiotechDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO