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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
AOX1 316 aldehyde oxidase 1  2AO, AOH1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
21400501   2011Cell line : -

Source : -

Sample Type : Fresh frozen CRC tissue

No. of Sample : -

Stage : TNM Stage I-IV

Methylation-Sensitive High Resolution Melting (MS-HRM) analysis, and Exon arrays ,real time RT-PCR,ImmunohistochemistryMethylation-Four of these genes (MLH1, AOX1, EYA4 and TWIST1) had previously been reported to be hypermethylated in CRC.


Gene Details



NC_000002.11 (201450731..201536218)

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Gene Type protein coding
Gene Family -
Description Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2q33
Start 201450731  
End 201536218  
Strand +  
Gene Sequence

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Length 85488  
OMIM ID 602841   
HGNC ID HGNC:553   
Unigene ID Hs.406238   
Ensembl ID ENSG00000138356   
PharmGKB ID PA24842   

mRNA Information


mRNA ID XM_011511062.1
Exon join(1..202,7195..7252,9321..9417,11446..11554, 13669..13795,16333..16394,17316..17405,18066..18146, 18745..18889,19585..19677,23033..23184,23370..23463, 25433..25542,26658..26842,27853..28015,30020..30112, 34699..34868,35169..35295,37910..38032,41402..41498, 48840..48964,50960..51093,52264..52351,55147..55233, 56659..56850,65023..65250,70891..70986,73214..73342, 74044..74118,75628..75680,76904..77018,80736..80801, 82664..82852,83624..83791,90927..91113)  
mRNA Sequence

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Length 4310  



CDS Information


   
Location158..4210
CDS Sequence

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CCDS ID CCDS33360.1



Protein Information


      
Protein IDXP_011509364.1
Protein Namealdehyde oxidase 1
Molecular Wt. (Da)149110
Protein Sequence

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Length 1350  
Uniprot IDP15529
Ensembl Protein ID ENSP00000313875  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


                                                      
Pathway Name Pathway ID
Drug metabolism - cytochrome P450 hsa00982
Jak-STAT signaling pathway hsa04630
Metabolic pathways hsa01100
Nicotinate and nicotinamide metabolism hsa00760
Retinol metabolism hsa00830
Tryptophan metabolism hsa00380
Tyrosine metabolism hsa00350
Valine, leucine and isoleucine degradation hsa00280
Vitamin B6 metabolism hsa00750


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam02738711-1245  Ald_Xan_dh_C2
cl03161711-1245  Ald_Xan_dh_C2 superfamily
pfam00941239-419  FAD_binding_5
cl19922239-419  FAD_binding_4 superfamily
smart01008594-701  Ald_Xan_dh_C
cl03161594-701  Ald_Xan_dh_C2 superfamily
pfam01315594-701  Ald_Xan_dh_C
pfam0179988-160  Fer2_2
cl0833488-160  Fer2_2 superfamily
pfam03450426-530  CO_deh_flav_C
cl08390426-530  CO_deh_flav_C superfamily
smart01092427-530  CO_deh_flav_C
TIGR029695-1338  mam_aldehyde_ox
PLN0290654-1321  PLN02906
TIGR02965580-1317  xanthine_xdhB
COG4631572-1317  XdhB
PLN001924-1293  PLN00192
TIGR029639-530  xanthine_xdhA
COG1529579-1311  CoxL
PRK09970580-1290  PRK09970
TIGR03194589-1311  4hydrxCoA_A
TIGR03196580-1287  pucD
COG46302-532  XdhA
TIGR03311572-1270  Se_dep_XDH
PRK09800578-1311  PRK09800
TIGR03313617-1311  Se_sel_red_Mo
TIGR02416595-1311  CO_dehy_Mo_lg
COG20809-160  CoxS
TIGR0319370-163  4hydroxCoAred
TIGR031989-166  pucE
TIGR033119-160  Se_dep_XDH
PRK09971244-519  PRK09971
COG1319246-519  CoxM
PRK114335-160  PRK11433
PRK0990883-167  PRK09908
TIGR03199246-518  pucC
TIGR03195246-504  4hydrxCoA_B
PRK0980070-155  PRK09800
PRK09799286-468  PRK09799
TIGR0331372-155  Se_sel_red_Mo
TIGR03312243-447  Se_sel_red_FAD


Ontology Information


   
HPRD ID1272
Molecular ClassEnzyme: Oxidase
Molecular FunctionUbiquitin-specific protease activity (GO:0004843)
Biological ProcessProtein metabolism (GO:0019538); Apoptosis (GO:0006915)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q06278DB00170MenadioneSmallMoleculeDrug
Q06278DB00339PyrazinamideSmallMoleculeDrug
Q06278DB00426FamciclovirSmallMoleculeDrug
Q06278DB00437AllopurinolSmallMoleculeDrug
Q06278DB00481RaloxifeneSmallMoleculeDrug
Q06278DB00484BrimonidineSmallMoleculeDrug
Q06278DB00513Aminocaproic AcidSmallMoleculeDrug
Q06278DB00563MethotrexateSmallMoleculeDrug
Q06278DB00909ZonisamideSmallMoleculeDrug
Q06278DB00962ZaleplonSmallMoleculeDrug
Q06278DB01033MercaptopurineSmallMoleculeDrug
Q06278DB09054IdelalisibSmallMoleculeDrug
Q06278DB09078LenvatinibSmallMoleculeDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO