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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
APC2 10297 adenomatosis polyposis coli 2  19APCL 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19750230   2009Cell line : -

Source : Shiraz University of Medical Sciences and Howard University Hospital.

Sample Type : CRCTumor

No. of Sample : ?102

Stage : -

Methylation-specific PCR Methylation-In colon carcinoma cells, loss of APC leads to the accumulation of betacatenin in the nucleus, where it binds to and activates the Tcf-4 transcription factor


Gene Details



NC_000019.9 (1446269..1473243)

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Gene Type protein coding
Gene Family Armadillo repeat containing
Description -  
Chromosome 19
Location 19p13.3
Start 1446269  
End 1473243  
Strand +  
Gene Sequence

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Length 26975  
OMIM ID 612034   
HGNC ID HGNC:24036   
Unigene ID Hs.446376   
Ensembl ID ENSG00000115266   
PharmGKB ID PA134906843   

mRNA Information


mRNA ID ?NM_005883.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS12068.1



Protein Information


      
Protein IDNP_005874.1
Protein Nameadenomatosis polyposis coli 2
Molecular Wt. (Da)0
Protein Sequence

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Length 2303  
Uniprot IDQ9Y696
Ensembl Protein ID ENSP00000363500  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1675

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1499CTNNB1286NP_001895.1in vitro;in vivo100   213   699   823   329   
22919MAPRE14379NP_036457.1in vitro10644998   
22924MAPRE316156NP_036458.2in vitro;in vivo;yeast 2-hybrid10644998   


Pathway Information


                                                            
Pathway Name Pathway ID
Basal cell carcinoma hsa05217
Colorectal cancer hsa05210
Endometrial cancer hsa05213
Hippo signaling pathway hsa04390
HTLV-I infection hsa05166
MicroRNAs in cancer hsa05206
Pathways in cancer hsa05200
Regulation of actin cytoskeleton hsa04810
Signaling pathways regulating pluripotency of stem cells hsa04550
Wnt signaling pathway hsa04310


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00020576-694  ARM
cl22454576-694  ARM superfamily
cd00020430-562  ARM
cl22454430-562  ARM superfamily
cd00020273-377  ARM
cl22454273-377  ARM superfamily
pfam11414123-206  Suppressor_APC
cl12943123-206  Suppressor_APC superfamily
cd00020527-654  ARM
cd00020406-518  ARM
cd00020619-701  ARM
smart00185614-654  ARM
pfam00514615-654  Arm
pfam059231146-1168  APC_crr
cl054711146-1168  APC_crr superfamily
pfam059231385-1410  APC_crr
cl054711385-1410  APC_crr superfamily
COG1382Sep-77  GimC
cl09111Sep-77  Prefoldin superfamily
pfam059561786-2113  APC_basic
PHA032471566-2098  PHA03247
PHA032471732-2245  PHA03247
PHA032471315-1911  PHA03247
PHA032471791-2279  PHA03247
PHA033071588-1962  PHA03307
PRK077641856-2219  PRK07764
PRK077641560-1965  PRK07764
PRK077641589-1966  PRK07764
PRK077641797-2219  PRK07764
PHA032472002-2227  PHA03247
PHA033071763-2220  PHA03307
PRK123231764-1971  PRK12323
PRK077642023-2300  PRK07764
PLN032371623-1866  PLN03237
PHA033071514-1912  PHA03307
COG11968-237  Smc
PHA033071745-2109  PHA03307
PRK077641517-1919  PRK07764
PRK077641518-1913  PRK07764
PRK077641722-2151  PRK07764
PHA032471372-1945  PHA03247
PRK077641413-1631  PRK07764
PHA033071858-2265  PHA03307
PRK070031603-1865  PRK07003
PRK149511766-1914  PRK14951
PRK123232048-2301  PRK12323
PHA033781732-1969  PHA03378
PRK123231963-2188  PRK12323
PRK123231717-1915  PRK12323
PRK070031748-1961  PRK07003
pfam154491589-1864  Retinal
PTZ004492049-2280  PTZ00449
PRK077642048-2299  PRK07764
PHA033781768-1958  PHA03378
PHA033091619-1960  PHA03309
PRK123232021-2236  PRK12323
PRK077641325-1661  PRK07764
PHA033071323-1679  PHA03307
PHA032472054-2303  PHA03247
PTZ004491727-1913  PTZ00449
PHA033781731-1859  PHA03378
PTZ004361739-1910  PTZ00436
PHA032471730-1965  PHA03247
PRK070031936-2221  PRK07003
COG11968-237  Smc


Ontology Information


   
HPRD ID5863
Molecular ClassTranscription regulatory protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO