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General Information
- Evidence
- Gene
- mRNA
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- Protein
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25721378 | 2015 | Cell line : - Source : - Sample Type : CRC Tumor and adjescent tissue No. of Sample : 486 Stage : - | Immunohistochemistry of tissue microarray | Up-regulation | - | Study found a significant correlation between AQP1, AQP3, and AQP5 expression and lymph node metastasis in patients with surgically resected colon cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Ion channels / Aquaporins, "Blood group antigens" |
| Description | This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] | Chromosome | 9 |
| Location | 9p13 |
| Start | 33441152 |
| End | 33447631 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6480 |
| OMIM ID | 600170 |
| HGNC ID | HGNC:636 |
| Unigene ID | Hs.234642 |
| Ensembl ID | ENSG00000165272 |
| PharmGKB ID | PA24921 |
mRNA Information
| mRNA ID | NM_004925.4 |
|---|---|
| Exon | join(1..211,3742..3868,4176..4313,4664..4782,5116..5333, 5423..6480) | mRNA Sequence | Download Select all |
| Length | 1882 |
Protein Information
| Protein ID | NP_004916.1 |
|---|---|
| Protein Name | aquaporin 3 (Gill blood group) |
| Molecular Wt. (Da) | 31413 |
| Protein Sequence | Download Select all |
| Length | 292 |
| Uniprot ID | P08581 |
| Ensembl Protein ID | ENSP00000317272 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5338 | PLD2 | 3857 | NP_002654.3 | in vitro;in vivo | 14675200 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Vasopressin-regulated water reabsorption | hsa04962 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00333 | 23-264 | MIP |
| cl00200 | 23-264 | MIP superfamily |
| PTZ00016 | 18-266 | PTZ00016 |
| COG0580 | 19-266 | GlpF |
| TIGR00861 | 27-261 | MIP |
| pfam00230 | 21-261 | MIP |
| PLN00183 | 22-283 | PLN00183 |
| PLN00182 | 21-264 | PLN00182 |
| PLN00184 | 14-264 | PLN00184 |
| PRK05420 | 21-266 | PRK05420 |
| PLN00026 | 21-261 | PLN00026 |
| PLN00166 | 22-278 | PLN00166 |
| PLN00027 | 22-277 | PLN00027 |
| PLN00167 | 22-114 | PLN00167 |
Ontology Information
| HPRD ID | 1122 |
|---|---|
| Molecular Class | Water channel |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.