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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25109507 | 2014 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 45 Stage : - | FISH | Up-regulation | - | AQP5 may be used as a novel biomarker for colorectal cancer aggressiveness and metastasis. AQP5 expression in colorectal cancer cells was upregulated compared to normal colon cells. |
| 23148732 | 2012 | Cell line : - Source : Department of Surgery, the First Affiliated Hospital of Liaoning Medical University Sample Type : CRC tumor and Normal tissue No. of Sample : 40 Stage : - | Real-time PCR, immunohistochemistry | Up-regulation | - | AQP5 might be a novel prognostic biomarker for patients with colorectal cancer. AQP5 was mainly expressed in colorectal carcinoma cells and barely expressed in paraneoplastic normal tissues. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Ion channels / Aquaporins |
| Description | Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. | Chromosome | 12 |
| Location | 12q13 |
| Start | 49961496 |
| End | 49965682 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 4187 |
| OMIM ID | 600442 |
| HGNC ID | HGNC:638 |
| Unigene ID | Hs.298023 |
| Ensembl ID | ENSG00000161798 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001651.3 |
|---|---|
| Exon | join(1..885,1997..2161,2597..2680,3497..4187) | mRNA Sequence | Download Select all |
| Length | 1840 |
CDS Information
| Location | join(523..885,1997..2161,2597..2680,3497..3682) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS8793.1 |
Protein Information
| Protein ID | NP_001642.1 |
|---|---|
| Protein Name | aquaporin 5 |
| Molecular Wt. (Da) | 28161 |
| Protein Sequence | Download Select all |
| Length | 265 |
| Uniprot ID | P01286 |
| Ensembl Protein ID | ENSP00000237527 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4188 | MDFI | 7280 | NP_005577.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Salivary secretion | hsa04970 |
Structure Information
| PDB ID | 3D9S |
|---|---|
| Resolution | 2 |
| Method | X-RAY DIFFRACTION |
| Chains | A,B,C |
| Molecule | Aquaporin-5 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00333 | 12-224 | MIP |
| cl00200 | 12-224 | MIP superfamily |
| pfam00230 | 4-221 | MIP |
| TIGR00861 | 16-221 | MIP |
| COG0580 | 11-227 | GlpF |
| PRK05420 | 11-225 | PRK05420 |
| PLN00166 | 7-221 | PLN00166 |
| PLN00027 | 11-221 | PLN00027 |
| PLN00167 | 3-228 | PLN00167 |
| PLN00184 | 7-221 | PLN00184 |
| PTZ00016 | 16-227 | PTZ00016 |
| PLN00182 | 1-226 | PLN00182 |
| PLN00026 | 8-221 | PLN00026 |
| PLN00183 | 11-221 | PLN00183 |
| COG0580 | 10-104 | GlpF |
Ontology Information
| HPRD ID | 1312 |
|---|---|
| Molecular Class | Water channel |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.