Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ARFGEF1 | 10565 | ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) | 8 | BIG1; P200; ARFGEP1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20089989 | 2010 | Cell line : - Source : VU University Medical Center, Amsterdam, The Netherlands. Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : TNM Stage II | Biochemical isolation to nano-LC-MS/MS analysis | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011] | Chromosome | 8 |
| Location | 8q13 |
| Start | 67175296 |
| End | 67343897 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 168602 |
| OMIM ID | 604141 |
| HGNC ID | HGNC:15772 |
| Unigene ID | Hs.656902 |
| Ensembl ID | ENSG00000066777 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_011517598.1 |
|---|---|
| Exon | complement(join(<147284..148516,150296..150434, 153139..153248,163972..164035,166172..166218, 168462..168602)) | mRNA Sequence | Download Select all |
| Length | 6272 |
CDS Information
| Location | complement(join(<148305..148516,150296..150434, 153139..153248,163972..164035,166172..166218, 168462..168602)) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_006412.2 |
|---|---|
| Protein Name | ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) |
| Molecular Wt. (Da) | 208637 |
| Protein Sequence | Download Select all |
| Length | 1849 |
| Uniprot ID | O95677 |
| Ensembl Protein ID | ENSP00000347294 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 1569;- |
| S | Phosphorylation | 1580 |
| S | Phosphorylation | 397 |
| S | Phosphorylation | 52 |
| S | Phosphorylation | 396 |
| S | Phosphorylation | 394 |
| S | Phosphorylation | 410 |
| K | Acetylation | 1708 |
| S | Phosphorylation | 234 |
| S | Phosphorylation | 237 |
| S | Phosphorylation | 243 |
| S | Phosphorylation | 403 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2286 | FKBP2 | 1742 | NP_004461.2 | in vitro;in vivo;yeast 2-hybrid | 12606707 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Endocytosis | hsa04144 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00171 | 698-882 | Sec7 |
| cl00136 | 698-882 | Sec7 superfamily |
| pfam01369 | 695-882 | Sec7 |
| smart00222 | 695-882 | Sec7 |
| pfam12783 | 416-579 | Sec7_N |
| cl20468 | 416-579 | Sec7_N superfamily |
| pfam09324 | 1219-1304 | DUF1981 |
| cl07820 | 1219-1304 | DUF1981 superfamily |
| PLN03076 | 15-1766 | PLN03076 |
| COG5307 | 427-1533 | COG5307 |
Ontology Information
| HPRD ID | 589 |
|---|---|
| Molecular Class | Guanine nucleotide exchange factor |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.