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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ARHGAP12 94134 Rho GTPase activating protein 12  10FLJ20737, FLJ10971, FLJ21785 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25749350   2015Cell line : -

Source : Patients from Finland

Sample Type : CRC tumor and normal tissue

No. of Sample : 117

Stage : -

Exom Sequencing,Sanger sequencing and genotypingMutation- Five genes with homozygous variants in early-onset CRC cases were found (MCTP2, ARHGAP12, ATM, DONSON, and ROS1), including one gene (MCTP2) with a homozygous splice site variant.


Gene Details



NC_000010.10 (32094326..32217804, complement)

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Gene Type protein coding
Gene Family Rho GTPase activating proteins, "Pleckstrin homology (PH) domain containing"
Description This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]  
Chromosome 10
Location 10p11.22
Start 32094326  
End 32217804  
Strand -  
Gene Sequence

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Length 123479  
OMIM ID 610577   
HGNC ID HGNC:16348   
Unigene ID Hs.499264   
Ensembl ID ENSG00000165322   
PharmGKB ID PA24957   

mRNA Information


mRNA ID ?NM_001270695.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS59214.1



Protein Information


      
Protein IDNP_001257624.1
Protein NameRho GTPase activating protein 12
Molecular Wt. (Da)0
Protein Sequence

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Length 846  
Uniprot IDQ5JTC6
Ensembl Protein ID ENSP00000329117  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation231
SPhosphorylation240
YPhosphorylation243
SPhosphorylation592
TPhosphorylation230;-
SPhosphorylation103
TPhosphorylation104
SPhosphorylation176
SPhosphorylation201
SPhosphorylation213
SPhosphorylation215
SPhosphorylation223
SPhosphorylation165
SPhosphorylation262
SPhosphorylation395
SPhosphorylation404
SPhosphorylation91

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd04403654-839  RhoGAP_ARHGAP27_15_12_9
cl02570654-839  RhoGAP superfamily
cd13233465-576  PH_ARHGAP9-like
cl17171465-576  PH-like superfamily
cd1207015-74  SH3_ARHGAP12
cl1703615-74  SH3 superfamily
cd00201268-298  WW
cl00157268-298  WW superfamily
pfam00620670-821  RhoGAP
smart00324667-837  RhoGAP
cd00159670-837  RhoGAP
cd04395653-844  RhoGAP_ARHGAP21
cd04398654-844  RhoGAP_fRGD1
cd04374671-839  RhoGAP_Graf
cd04372654-844  RhoGAP_chimaerin
cd04377654-839  RhoGAP_myosin_IX
cd04387654-835  RhoGAP_Bcr
cd04378654-837  RhoGAP_GMIP_PARG1
cd04404652-844  RhoGAP-p50rhoGAP
cd04386652-844  RhoGAP_nadrin
cd04407654-814  RhoGAP_myosin_IXB
cd04382669-844  RhoGAP_MgcRacGAP
cd04384653-817  RhoGAP_CdGAP
cd04373654-836  RhoGAP_p190
cd04409654-837  RhoGAP_PARG1
cd04400653-845  RhoGAP_fBEM3
cd04385669-838  RhoGAP_ARAP
cd04379654-820  RhoGAP_SYD1
cd04408654-837  RhoGAP_GMIP
cd04376669-817  RhoGAP_ARHGAP6
cd04391653-815  RhoGAP_ARHGAP18
cd1188816-68  SH3_ARHGAP9_like
cd04383654-836  RhoGAP_srGAP
cd04402654-845  RhoGAP_ARHGAP20
cd04406654-839  RhoGAP_myosin_IXA
cd04381669-812  RhoGap_RalBP1
cd04390653-818  RhoGAP_ARHGAP22_24_25
cd04393652-810  RhoGAP_FAM13A1a
cd1206916-71  SH3_ARHGAP27
cd04375653-812  RhoGAP_DLC1
cd04397654-837  RhoGAP_fLRG1
cd04392682-844  RhoGAP_ARHGAP19
cd04394653-846  RhoGAP-ARHGAP11A
cd04396667-813  RhoGAP_fSAC7_BAG7
cd04389688-822  RhoGAP_KIAA1688
cd1214317-68  SH3_ARHGAP9
cd04388670-814  RhoGAP_p85
smart00233479-575  PH
cd04399654-819  RhoGAP_fRGD2
cd10571477-572  PH_beta_spectrin
pfam00169479-574  PH
pfam1460419-70  SH3_9
cd01253465-572  PH_ARHGAP21-like
cd1177519-70  SH3_Sla1p_3
cd04380646-842  RhoGAP_OCRL1
cd1200721-69  SH3_Yes
cd1176823-71  SH3_Tec_like
cd01230466-572  PH1_Tiam1_2
cd13301482-574  PH1_Pleckstrin_2
cd00821479-570  PH
cd1180816-70  SH3_Alpha_Spectrin
cd13282466-578  PH1_PLEKHH1_PLEKHH2
pfam00397269-296  WW
cd13215479-570  PH-GRAM1_AGT26
smart0032613-70  SH3
smart00456271-298  WW
cd1190823-71  SH3_ITK
pfam0001823-66  SH3_1
cd13276481-566  PH_AtPH1
cd1177319-68  SH3_Sla1p_1
cd1200621-69  SH3_Fyn_Yrk
cd13296483-581  PH2_MyoX
cd1184523-68  SH3_Src_like
cd1190620-71  SH3_BTK
cd1200823-69  SH3_Src
cd01260473-578  PH_CNK_mammalian-like
cd0017416-68  SH3
cd1184923-70  SH3_SPIN90
cd1190521-71  SH3_Tec
pfam15410478-575  PH_9
cd04401692-810  RhoGAP_fMSB1
cd1185818-71  SH3_Myosin-I_fungi
COG5104259-412  PRP40


Ontology Information


   
HPRD ID16335
Molecular ClassGTPase activating protein
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessBiological_process unknown (GO:0000004)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO