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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ARID1B 57492 AT rich interactive domain 1B (SWI1-like)  6KIAA1235, ELD/OSA1, p250R, BAF250b, DAN15, 6A3-5 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24382590   2014Cell line : -

Source : -

Sample Type : DNA Sample

No. of Sample : 25 sporadic MSI CRCs and normal DNA pairs

Stage : -

Exome capture and sequencing,Read mapping and variant callingMutation-ARID1B (13%, 6/46), ARID2 (13%, 6/46) and ARID4A (20%, 9/46) were frequently mutated.


Gene Details



NC_000006.11 (157098980..157531913)

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Gene Type protein coding
Gene Family -
Description This locus encodes an AT-rich DNA interacting domain-containing protein. The encoded protein is a component of the SWI/SNF chromatin remodeling complex and may play a role in cell-cycle activation. The protein encoded by this locus is similar to AT-rich interactive domain-containing protein 1A. These two proteins function as alternative, mutually exclusive ARID-subunits of the SWI/SNF complex. The associated complexes play opposing roles. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2012]  
Chromosome 6
Location 6q25.3
Start 157098980  
End 157531913  
Strand +  
Gene Sequence

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Length 432934  
OMIM ID 614556   
HGNC ID HGNC:18040   
Unigene ID Hs.291587   
Ensembl ID ENSG00000049618   
PharmGKB ID PA134909463   

mRNA Information


mRNA ID ?NM_017519.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS5251.2



Protein Information


      
Protein IDNP_059989.2
Protein NameAT rich interactive domain 1B (SWI1-like)
Molecular Wt. (Da)0
Protein Sequence

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Length 2236  
Uniprot IDQ86UX2
Ensembl Protein ID ENSP00000256861  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KSumoylation958
KSumoylation971
KSumoylation958
SPhosphorylation458
SPhosphorylation458
SPhosphorylation458
SPhosphorylation1550
SPhosphorylation1554
SPhosphorylation1510
SPhosphorylation1514
SPhosphorylation1497
SPhosphorylation1501
SPhosphorylation574
SPhosphorylation587
SPhosphorylation574
KAcetylation1772
KAcetylation1732
KAcetylation1719
KAcetylation1561
KAcetylation1521
KAcetylation1508
SPhosphorylation1537
SPhosphorylation1497
SPhosphorylation1484
SPhosphorylation1710
SPhosphorylation1670
SPhosphorylation1657
SPhosphorylation367
SPhosphorylation367
SPhosphorylation367
SPhosphorylation1235
TPhosphorylation1237
SPhosphorylation1195
TPhosphorylation1197
SPhosphorylation1182
TPhosphorylation1184
SPhosphorylation1223
SPhosphorylation1229
SPhosphorylation1183
SPhosphorylation1189
SPhosphorylation1170
SPhosphorylation1176

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                             
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
4093SMAD94484BAA21128.1yeast 2-hybrid15231748   
6595SMARCA22483NP_003061.3in vitro;in vivo12200431   
6597SMARCA44459NP_001122321.1in vitro;in vivo;yeast 2-hybrid1   198   809   912   200   430   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam120311926-2182  DUF3518
cl134671926-2182  DUF3518 superfamily
smart005011054-1145  BRIGHT
cl026331054-1145  ARID superfamily
pfam013881050-1140  ARID
smart010141054-1140  ARID
COG5498698-764  Acf2
cl02310698-764  Glyco_hydro_81 superfamily
pfam096061177-1557  Med15
PHA03307661-913  PHA03307
PRK10263673-861  PRK10263
pfam031571160-1473  Glutenin_hmw
pfam097701275-1502  PAT1
pfam15362677-877  Enamelin
pfam097701329-1605  PAT1
pfam097701299-1510  PAT1
pfam05109663-1019  Herpes_BLLF1
PRK14086703-913  dnaA
PRK12323684-809  PRK12323
pfam12004658-909  DUF3498
PHA03247702-1012  PHA03247
pfam09770696-877  PAT1
pfam04652644-775  DUF605
PLN02217675-789  PLN02217
pfam03153652-825  TFIIA
PRK12495677-767  PRK12495
PRK07764677-817  PRK07764
TIGR016281331-1476  PABP-1234
pfam04652705-807  DUF605
pfam03154634-911  Atrophin-1
TIGR016281386-1518  PABP-1234
pfam09770689-908  PAT1
pfam09606693-1009  Med15
PRK10263667-847  PRK10263
pfam031531405-1543  TFIIA
pfam03154680-913  Atrophin-1
PHA03307658-844  PHA03307
PLN02983709-773  PLN02983
PRK07764685-860  PRK07764


Ontology Information


   
HPRD ID16854
Molecular ClassTranscription factor
Molecular FunctionCalcium ion binding (GO:0005509)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
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