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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
ARL5A 26225 ADP-ribosylation factor-like 5A  2- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24327274   2014Cell line : HCT 8, HCT 116, LoVo, DLD1, SW480, SW620

Source : ATCC and Fudan University Shanghai Cancer Center

Sample Type : CRC tumor and normal tissue

No. of Sample : 94

Stage : -

real time RT-PCR, immunohistochemistry,microarray,Luciferase assay and Western blottingUp-regulation-ARL5A mRNA and protein levels were upregulated in colorectal cancer samples compared with NCTs and high ARL5A protein levels predicted a poor prognosis.


Gene Details



NC_000002.11 (152657480..152685009, complement)

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Gene Type protein coding
Gene Family ADP-ribosylation factors-like, "ADP-ribosylation factors"
Description The protein encoded by this gene belongs to the ARF family of GTP-binding proteins. With its distinctive nuclear/nucleolar localization and interaction with HP1alpha, the protein is developmentally regulated and may play a role(s) in nuclear dynamics and/or signaling cascades during embryonic development. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2q23.3
Start 152657480  
End 152685009  
Strand -  
Gene Sequence

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Length 27530  
OMIM ID 608960   
HGNC ID HGNC:696   
Unigene ID Hs.470233   
Ensembl ID ENSG00000162980   
PharmGKB ID PA24989   

mRNA Information


mRNA ID ?NM_001037174.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS2195.1



Protein Information


      
Protein IDNP_001032251.1
Protein NameADP-ribosylation factor-like 5A
Molecular Wt. (Da)0
Protein Sequence

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Length 179  
Uniprot IDQ9BV57
Ensembl Protein ID ENSP00000333666  



Post-translational Modification Information (Source : HPRD)


Residue Type site
GMyristoylation2

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
3838KPNA22818NP_002257.1in vitro12414990   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd041533-175  Arl5_Arl8
cl214553-175  P-loop_NTPase superfamily
cd0087818-175  Arf_Arl
pfam0002515-172  Arf
cd0415118-172  Arl1
PTZ001331-177  PTZ00133
PLN002231-179  PLN00223
smart001771-177  ARF
cd0415018-172  Arf1_5_like
cd041555-171  Arl3
cd0414910-172  Arf6
cd0415416-172  Arl2
cd0415618-169  ARLTS1
cd0416019-175  Arfrp1
cd0415719-172  Arl6
cd0415219-170  Arl4_Arl7
cd0415818-176  ARD1
cd0087914-172  Sar1
cd0415921-175  Arl10_like
cd0416219-157  Arl9_Arfrp2_like
cd0416119-174  Arl2l1_Arl13_like
cd0088221-174  Ras_like_GTPase
cd0015418-164  Rab
cd0410519-129  SR_beta
COG222912-174  Srp102
cd0411318-165  Rab4
cd0413917-155  RalA_RalB
cd0411518-135  Rab33B_Rab33A
cd0411010-128  Rab35
pfam0847718-128  Miro
cd0186117-135  Rab6
cd0410817-165  Rab36_Rab34
smart0017518-135  RAB
cd0186318-97  Rab18
cd0412018-140  Rab12
cd0411217-128  Rab26
cd0410618-149  Rab23_like
cd0991416-100  RocCOR
cd0412318-137  Rab21
cd0411118-97  Rab39
cd0088021-165  Era_like
cd0186418-131  Rab19
cd0412218-97  Rab14
pfam0192618-126  MMR_HSR1
cd0186818-96  Rab11_like
cd0186018-141  Rab5_related
cd0186618-129  Rab2
cd0087718-143  Ran
cd0411917-137  RJL
cd0186218-131  Rab7
cd0186918-147  Rab1_Ypt1
cd0410718-94  Rab32_Rab38
cd0412718-137  Rab27A
cd0414418-128  Ras2
cd0087618-135  Ras
cd0186718-97  Rab8_Rab10_Rab13_like
cd0410218-128  RabL3
cd0411718-94  Rab15
cd0411418-131  Rab30
cd0411618-131  Rab9
cd0015718-93  Rho
cd0186518-97  Rab3
cd0412918-95  Rho2
cd0411818-106  Rab24
pfam0007118-164  Ras
smart0017814-172  SAR
COG110018-128  Gem1
TIGR0023118-130  small_GTP
PLN0311818-97  PLN03118
pfam0943919-128  SRPRB
PLN0310818-143  PLN03108
PLN0311018-137  PLN03110
pfam0050324-129  G-alpha
PLN0307118-130  PLN03071
smart0017622-131  RAN
PTZ0013216-131  PTZ00132
pfam0467018-150  Gtr1_RagA
PTZ0036916-137  PTZ00369
PTZ0009961-135  PTZ00099


Ontology Information


   
HPRD ID12664
Molecular ClassGTPase
Molecular FunctionRibonucleoprotein (GO:0003733)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO