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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ARNT | 405 | aryl hydrocarbon receptor nuclear translocator | 1 | HIF1B; TANGO; bHLHe2; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25839165 | 2015 | Cell line : SW480 Source : National Cheng Kung University Hospital. Sample Type : CRC Tumor and adjecent normal tissue No. of Sample : 38 Stage : TNM stages I-IV | Transfection, luciferase assay,Immunofluorescence,Western blotting,Wound healing assay,RT-PCR,Transwell invasion assay,Immunohistochemistry. | Down-regulation | - | ARNT may play a positive role during tumor growth (either in early-stage tumor growth or in organ metastases), but plays a negative role in tumor migration and invasion. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013] | Chromosome | 1 |
| Location | 1q21 |
| Start | 150782181 |
| End | 150849244 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 67064 |
| OMIM ID | 126110 |
| HGNC ID | HGNC:700 |
| Unigene ID | Hs.632446 |
| Ensembl ID | ENSG00000143437 |
| PharmGKB ID | PA24994 |
Protein Information
| Protein ID | |
|---|---|
| Protein Name | aryl hydrocarbon receptor nuclear translocator |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 0 |
| Uniprot ID | O75030 |
| Ensembl Protein ID | ENSP00000324246 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Sumoylation | 245 |
| K | Sumoylation | 230 |
| S | Phosphorylation | 77 |
| S | Phosphorylation | 77 |
| K | Sumoylation | 245 |
| S | Phosphorylation | 68 |
| S | Phosphorylation | 68 |
| S | Phosphorylation | 68 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 196 | AHR | 2596 | NP_001612.1 | in vitro;in vivo;yeast 2-hybrid | 8 384 309 748 824 770 000 000 000 000 000 000 000 |
| 2033 | EP300 | 4078 | NP_001420.2 | in vivo | 10999956 |
| 2099 | ESR1 | 589 | NP_000116.2 | in vitro | 15837795 |
| 4093 | SMAD9 | 4484 | BAA21128.1 | yeast 2-hybrid | 15231748 |
| 5371 | PML | 23 | NP_150241.2 | in vitro | 12354770 |
| 6493 | SIM2 | 2935 | NP_005060.1 | in vitro;in vivo;yeast 2-hybrid | 9 020 169 927 137 210 000 000 |
| 9915 | ARNT2 | 6915 | NP_055677.3 | yeast 2-hybrid | 8927054 |
| 23462 | HEY1 | 4260 | NP_001035798.1 | yeast 2-hybrid | 10692439 |
| 23493 | HEY2 | 5243 | NP_036391.1 | yeast 2-hybrid | 10692439 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemical carcinogenesis | hsa05204 |
| HIF-1 signaling pathway | hsa04066 |
| Pathways in cancer | hsa05200 |
| Renal cell carcinoma | hsa05211 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00130 | 362-458 | PAS |
| cl21578 | 362-458 | PAS superfamily |
| cd00083 | 91-143 | HLH |
| cl00081 | 91-143 | HLH superfamily |
| cd00130 | 172-269 | PAS |
| cl21578 | 172-269 | PAS superfamily |
| pfam00010 | 91-143 | HLH |
| smart00353 | 95-143 | HLH |
| smart00091 | 362-417 | PAS |
| smart00091 | 166-230 | PAS |
| smart00086 | 424-464 | PAC |
| cl09965 | 424-464 | PAC superfamily |
| pfam14598 | 362-462 | PAS_11 |
| pfam00989 | 163-269 | PAS |
| pfam08447 | 373-461 | PAS_3 |
| pfam13426 | 368-460 | PAS_9 |
| TIGR00229 | 370-442 | sensory_box |
| pfam00989 | 368-460 | PAS |
| pfam08447 | 186-225 | PAS_3 |
Ontology Information
| HPRD ID | 390 |
|---|---|
| Molecular Class | Not Available |
| Molecular Function | DNA repair protein (GO:0003685) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.