Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ARNTL | 406 | Aryl hydrocarbon receptor nuclear translocator-like | 11 | TIC; JAP3; MOP3; BMAL1; PASD3; BMAL1c; bHLHe5 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23001810 | 2012 | Cell line : - Source : - Sample Type : Mouse model No. of Sample : - Stage : - | Gene expression profiles | Down-regulation | - | Inadequate folate intake increases risk for colorectal cancer. To identify genes involved in tumorigenesis compared gene expression profiles. |
| 24277452 | 2014 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Flow cytometry, Western blotting, Immunohistochemistry | Up-regulation | - | Bmal1 shows the potential as a novel prognostic biomarker and may represent a new therapeutic target in colorectal cancer. the overall survival of patients with colorectal cancer with high Bmal1 levels in their primary tumors was significantly longer than that of patients with low Bmal1 levels. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Basic helix-loop-helix proteins |
| Description | The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | Chromosome | 11 |
| Location | 11p15 |
| Start | 13277727 |
| End | 13387811 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 110085 |
| OMIM ID | 602550 |
| HGNC ID | HGNC:701 |
| Unigene ID | Hs.65734 |
| Ensembl ID | ENSG00000133794 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001297719.1 |
|---|---|
| Exon | join(1..197,32261..32333,48687..48741,72219..72344, 76575..76722,79013..79051,79329..79370,80708..80865, 82619..82698,87774..87866,88939..89056,91892..92041, 94437..94683,96369..96475,97886..98036,98914..99002, 100611..100719,103435..103528,107963..108065, 108870..109540) | mRNA Sequence | Download Select all |
| Length | 2812 |
CDS Information
| Location | join(76583..76722,79013..79051,79329..79370,80708..80865, 82619..82698,87774..87866,88939..89056,91892..92041, 94437..94683,96369..96475,97886..98036,98914..99002, 100596..100719,103435..103528,107963..108065, 108870..109030) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001284648.1 |
|---|---|
| Protein Name | Aryl hydrocarbon receptor nuclear translocator-like |
| Molecular Wt. (Da) | 68631 |
| Protein Sequence | Download Select all |
| Length | 626 |
| Uniprot ID | P78504 |
| Ensembl Protein ID | ENSP00000254958 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 78 |
| S | Phosphorylation | 78 |
| S | Phosphorylation | 35 |
| K | Sumoylation | 259 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 196 | AHR | 2596 | NP_001612.1 | in vivo;yeast 2-hybrid | 9079689 |
| 1454 | CSNK1E | 2919 | NP_001885.1 | in vitro | 11875063 |
| 3131 | HLF | 797 | NP_002117.1 | in vitro;yeast 2-hybrid | 9704006 |
| 3320 | HSP90AA1 | 777 | NP_001017963.2 | in vivo | 9079689 |
| 9575 | CLOCK | 3508 | NP_004889.1 | in vivo | 9989497 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Circadian rhythm | hsa04710 |
| Dopaminergic synapse | hsa04728 |
| Herpes simplex infection | hsa05168 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00083 | 71-126 | HLH |
| cl00081 | 71-126 | HLH superfamily |
| cd00130 | 341-436 | PAS |
| cl21578 | 341-436 | PAS superfamily |
| cd00130 | 155-234 | PAS |
| cl21578 | 155-234 | PAS superfamily |
| pfam00010 | 74-126 | HLH |
| smart00353 | 80-126 | HLH |
| smart00091 | 149-208 | PAS |
| smart00091 | 341-394 | PAS |
| smart00086 | 401-441 | PAC |
| cl09965 | 401-441 | PAC superfamily |
| pfam14598 | 339-441 | PAS_11 |
| pfam00989 | 146-253 | PAS |
| pfam00989 | 347-435 | PAS |
| pfam08447 | 350-434 | PAS_3 |
| TIGR00229 | 347-437 | sensory_box |
| TIGR00229 | 150-209 | sensory_box |
| pfam13426 | 348-437 | PAS_9 |
| pfam13426 | 156-234 | PAS_9 |
| pfam08447 | 169-208 | PAS_3 |
Ontology Information
| HPRD ID | 3562 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Receptor activity (GO:0004872) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.