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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
- PPi
- Pathway
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- Domain
- Ontology
- SNP
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25755742 | 2015 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 111 colon tissues samples including 55 from adjacent noncancerous tissues and 56 from tumors tissues. Stage : - | Downloading from GEO (Gene Expression Omnibus) database, Microarray data GSE44861,Bayes moderated t-test, DIVAD was recruited to perform functional analysis for DEGs. | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Proteoglycans / Extracellular Matrix : Small leucine-rich repeats |
| Description | This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants.[provided by RefSeq, Jul 2014] | Chromosome | 9 |
| Location | 9q22.31 |
| Start | 95218487 |
| End | 95244844 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 26358 |
| OMIM ID | 608135 |
| HGNC ID | HGNC:14872 |
| Unigene ID | Hs.435655 |
| Ensembl ID | ENSG00000106819 |
| PharmGKB ID | PA25057 |
Protein Information
| Protein ID | NP_001180264.1 |
|---|---|
| Protein Name | asporin |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 380 |
| Uniprot ID | Q8NEZ4 |
| Ensembl Protein ID | ENSP00000262189 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 282 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00013 | 74-104 | LRRNT |
| cl02423 | 74-104 | LRRNT superfamily |
| cd00116 | 143-340 | LRR_RI |
| cl23707 | 143-340 | LRR_RI superfamily |
| pfam01462 | 74-101 | LRRNT |
| pfam12799 | 265-306 | LRR_4 |
| cl19302 | 265-306 | LRR_4 superfamily |
| pfam12799 | 126-166 | LRR_4 |
| pfam12799 | 105-143 | LRR_4 |
| cl19302 | 105-143 | LRR_4 superfamily |
| pfam12799 | 241-282 | LRR_4 |
| pfam13855 | 105-162 | LRR_8 |
| pfam13855 | 241-301 | LRR_8 |
| PRK15370 | 91-327 | PRK15370 |
| COG4886 | 88-327 | LRR |
| pfam13855 | 126-207 | LRR_8 |
| PRK15370 | 154-324 | PRK15370 |
| pfam13855 | 267-324 | LRR_8 |
| PLN00113 | 106-333 | PLN00113 |
| PRK15387 | 85-316 | PRK15387 |
| PRK15370 | 84-175 | PRK15370 |
| PRK15370 | 84-263 | PRK15370 |
| PLN00113 | 95-324 | PLN00113 |
| PLN00113 | 234-325 | PLN00113 |
| pfam13855 | 172-219 | LRR_8 |
| PLN03150 | 260-325 | PLN03150 |
Ontology Information
| HPRD ID | 6004 |
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | G-protein coupled receptor activity (GO:0004930) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.